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SOPs (1)
Uploader: Maria Thomas
Contributor: Maria Thomas, Ulrich Zanger
Other contributors: Not specified
Version: 1
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase LPS and Inflammation, Showcase Steatosis, Virtual Liver
Scales: Cell
Chromatin immunoprecipitation (ChIP) is a valuable tool to detect the interaction between a transcription factor (TF) and DNA fragments in vivo. This technology enables distinguishing between direct and indirect responsive targets when combined with approaches of gene expression assessment following activation of a TF. ChIP may be used to confirm in vivo association of a transcriptional regulator with suspected target DNA fragments. Moreover, this method may also be used to discover new targets,
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Created: 24th Jan 2014 at 15:34  Last updated: 26th Jan 2014 at 07:50
Publications (3)
TFpredict and SABINE: Sequence-Based Prediction of Structural and Functional Characteristics of Transcription Factors
Authors: Johannes Eichner, Florian Topf, Andreas Dräger, Clemens Wrzodek, Dierk Wanke, Andreas Zell
DOI: 10.1371/journal.pone.0082238
Date Published: 12th Dec 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS ONE
Citation: PLoS ONE 8(12) : e82238
Scales: Cell and Intercellular
Abstract (Expand)
Created: 17th Nov 2015 at 12:27  Last updated: 17th Nov 2015 at 12:28
A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models
Authors: A. Ryll, J. Bucher, A. Bonin, S. Bongard, E. Gonçalves, J. Saez-Rodriguez, J. Niklas, S. Klamt
DOI: 10.1016/j.biosystems.2014.07.002
Date Published: 1st Jul 2014
Projects: A1: Cellular metabolism, A2.5: Integration of insulin and Wnt signalling in hepatocytes, A2: Integration of Signalling Pathways in Hepatocellular Response, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, Showcase Steatosis, Virtual Liver
Journal: Biosystems
Citation: Biosystems
Scales: Cell
Abstract (Expand)
Created: 6th Aug 2014 at 07:36  Last updated: 6th Aug 2014 at 07:50
Authors: Philip Stegmaier, Alexander Kel, Edgar Wingender, Jürgen Borlak
DOI: 10.1371/journal.pcbi.1002958
Date Published: 21st Mar 2013
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 9(3) : e1002958
Scales: Cell
Abstract (Expand)
Created: 28th Mar 2013 at 11:59  Last updated: 24th Oct 2013 at 16:14