Virtual Liver SEEK

3 items tagged with 'cytochrome P450'.

Publications (3)

Activating and Inhibitory Functions of WNT/β-catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

Authors: Maria Thomas, Christine Bayha, Silvia Vetter, Ute Hofmann, Michael Schwarz, Ulrich M Zanger, Albert Braeuning

PubMed ID: 25824487

Date Published: 1st Apr 2015

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase Steatosis

Journal: Mol. Pharmacol.

Citation: Mol. Pharmacol. :

Scales: Cell

Abstract (Expand)

The WNT/β-catenin signaling pathway has been identified as an important endogenous regulator of hepatic cytochrome P450 (CYP) expression in mouse liver. In particular, it is involved in the regulation ...

Created: 7th Apr 2015 at 14:00

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

Authors: Ulrich M Zanger, Matthias Schwab

PubMed ID: 23333322

Date Published: 16th Jan 2013

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models

Journal: Pharmacol. Ther.

Citation: Pharmacol. Ther. 138(1): 103-41

Scales: Not specified

Abstract (Expand)

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging to the CYP1, 2, and 3 families, ...

Created: 8th Jan 2014 at 14:40

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

Authors: Kathrin Klein, Ulrich M Zanger

PubMed ID: 23444277

Date Published: 25th Feb 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Front Genet

Citation: Front Genet 4: 12

Scales: Not specified

Abstract (Expand)

CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its prominent expression in liver and gut and because of its broad substrate specificity, which includes drugs from most ...

Created: 8th Jan 2014 at 14:16