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Publications (8)
Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling
Authors: Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F. Templin, Thomas O. Joos, Wolfgang E. Thasler, Andreas Zell, Ulrich M. Zanger
DOI: 10.1371/journal.pcbi.1004431
Date Published: 4th Jan 2016
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 12(1) : e1004431
Scales: Cell
Abstract (Expand)
Created: 7th Jan 2016 at 15:20  Last updated: 7th Jan 2016 at 15:24
Activating and Inhibitory Functions of WNT/β-catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells
Authors: Maria Thomas, Christine Bayha, Silvia Vetter, Ute Hofmann, Michael Schwarz, Ulrich M Zanger, Albert Braeuning
PubMed ID: 25824487
Date Published: 1st Apr 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. :
Authors: Kathrin Klein, Ulrich M Zanger
PubMed ID: 23444277
Date Published: 25th Feb 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Front Genet
Citation: Front Genet 4: 12
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:16
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Authors: Ulrich M Zanger, Kathrin Klein
PubMed ID: 23467454
Date Published: 5th Mar 2013
Projects: A3.4: Linking signalling to metabolic functions
Journal: Front Genet
Citation: Front Genet 4: 24
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:10
Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools
Authors: Robert Radloff, Alain Gras, Ulrich M Zanger, Cécile Masquelier, Karthik Arumugam, Jean-Claude Karasi, Vic Arendt, Carole Seguin-Devaux, Kathrin Klein
PubMed ID: 23418033
Date Published: 11th Mar 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Hum. Mutat.
Citation: Hum. Mutat. 34(5): 725-34
Scales: Not specified
Abstract (Expand)
Created: 13th Jan 2014 at 10:17
Authors: Tarek Magdy, Rudolf Arlanov, Stefan Winter, Thomas Lang, Kathrin Klein, Yu Toyoda, Toshihisa Ishikawa, Matthias Schwab, Ulrich M Zanger
PubMed ID: 24024896
Date Published: 13th Sep 2013
Projects: A3.4: Linking signalling to metabolic functions, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Pharmacogenomics
Citation: Pharmacogenomics 14(12): 1433-48
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:01
Authors: Ulrich M Zanger, Kathrin Klein, Maria Thomas, Jessica K Rieger, Roman Tremmel, Benjamin A Kandel, Marcus Klein, Tarek Magdy
PubMed ID: 24196843
Date Published: 8th Nov 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Clin. Pharmacol. Ther.
Citation: Clin. Pharmacol. Ther. :
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 13:58
Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα)
Authors: Maria Thomas, Oliver Burk, Britta Klumpp, Benjamin A Kandel, Georg Damm, Thomas S Weiss, Kathrin Klein, Matthias Schwab, Ulrich M Zanger
PubMed ID: 23295386
Date Published: 9th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. 83(3): 709-18
Scales: Cell
Abstract (Expand)
Created: 9th Jan 2013 at 15:04  Last updated: 24th Oct 2013 at 16:15