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5 items tagged with 'PPARalpha'.
SOPs (1)
Uploader: Maria Thomas
Contributor: Maria Thomas, Ulrich Zanger
Other contributors: Not specified
Version: 1
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase LPS and Inflammation, Showcase Steatosis, Virtual Liver
Scales: Cell
Chromatin immunoprecipitation (ChIP) is a valuable tool to detect the interaction between a transcription factor (TF) and DNA fragments in vivo. This technology enables distinguishing between direct and indirect responsive targets when combined with approaches of gene expression assessment following activation of a TF. ChIP may be used to confirm in vivo association of a transcriptional regulator with suspected target DNA fragments. Moreover, this method may also be used to discover new targets,
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Created: 24th Jan 2014 at 15:34 Last updated: 26th Jan 2014 at 07:50
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Download Publications (4)
Authors: Maria Thomas, Christine Bayha, Silvia Vetter, Ute Hofmann, Michael Schwarz, Ulrich M Zanger, Albert Braeuning
PubMed ID: 25824487
Date Published: 1st Apr 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. :
Authors: Maria Thomas, Oliver Burk, Britta Klumpp, Benjamin A Kandel, Georg Damm, Thomas S Weiss, Kathrin Klein, Matthias Schwab, Ulrich M Zanger
PubMed ID: 23295386
Date Published: 9th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. 83(3): 709-18
Scales: Cell
Abstract (Expand)
Created: 9th Jan 2013 at 15:04 Last updated: 24th Oct 2013 at 16:15
Authors: Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K Nussler, Mikko Niemi, Matthias Schwab, Ulrich M Zanger
PubMed ID: 22510778
Date Published: 18th Apr 2012
Projects: A3.4: Linking signalling to metabolic functions
Journal: Clinical pharmacology and therapeutics
Citation: Clin. Pharmacol. Ther. 91(6): 1044-52
Scales: Not specified
Abstract (Expand)
Created: 14th May 2012 at 09:40 Last updated: 24th Oct 2013 at 16:16
Authors: A Schröder, K Klein, S Winter, M Schwab, M Bonin, A Zell, U M Zanger
PubMed ID: 22006096
Date Published: 18th Oct 2011
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, C3: Zonation of metabolism and its regulation, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Not specified
Citation: Pharmacogenomics J. 13(1): 12-20
Scales: Not specified
Abstract (Expand)
Created: 3rd Nov 2011 at 10:45 Last updated: 24th Oct 2013 at 16:17
