Virtual Liver SEEK

4 items tagged with 'Nuclear receptors'.

Publications (4)

Genetics, epigenetics and regulation of drug metabolizing cytochrome P450 enzymes

Authors: Ulrich M Zanger, Kathrin Klein, Maria Thomas, Jessica K Rieger, Roman Tremmel, Benjamin A Kandel, Marcus Klein, Tarek Magdy

PubMed ID: 24196843

Date Published: 8th Nov 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Clin. Pharmacol. Ther.

Citation: Clin. Pharmacol. Ther. :

Scales: Not specified

Abstract (Expand)

Of 57 functional human cytochromes P450 (CYP) about a dozen liver-expressed, highly variable forms are responsible for the biotransformation of most drugs. Owing to numerous genetic and non-genetic ...

Created: 8th Jan 2014 at 13:58

No activation of human PXR by hyperforin-related phloroglucinols

Authors: Benjamin A Kandel, Sean Ekins, Kristina Leuner, Wolfgang E Thasler, Christian Harteneck, Ulrich M Zanger

PubMed ID: 24259679

Date Published: 22nd Nov 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: J. Pharmacol. Exp. Ther.

Citation: J. Pharmacol. Exp. Ther. :

Scales: Not specified

Abstract (Expand)

The acylated phloroglucinol, hyperforin, the main active ingredient of St John's wort, exerts anti-depressant properties via indirect inhibition of serotonin reuptake by selectively activating the ...

Created: 8th Jan 2014 at 13:53

Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα)

Authors: Maria Thomas, Oliver Burk, Britta Klumpp, Benjamin A Kandel, Georg Damm, Thomas S Weiss, Kathrin Klein, Matthias Schwab, Ulrich M Zanger

PubMed ID: 23295386

Date Published: 9th Jan 2013

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, Showcase Steatosis

Journal: Mol. Pharmacol.

Citation: Mol. Pharmacol. 83(3): 709-18

Scales: Cell

Abstract (Expand)

The nuclear receptor peroxisome proliferator-activated receptor (PPAR)α is primarily known as a regulator of fatty acid metabolism, energy balance, and inflammation, but there is evidence suggesting a ...

Created: 9th Jan 2013 at 15:04 Last updated: 24th Oct 2013 at 16:15

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Authors: Kathrin Klein, Maria Thomas, Stefan Winter, Andreas K Nussler, Mikko Niemi, Matthias Schwab, Ulrich M Zanger

PubMed ID: 22510778

Date Published: 18th Apr 2012

Projects: A3.4: Linking signalling to metabolic functions

Journal: Clinical pharmacology and therapeutics

Citation: Clin. Pharmacol. Ther. 91(6): 1044-52

Scales: Not specified

Abstract (Expand)

Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely heritable; however, predictive genetic factors have remained scarce. Using a candidate-gene approach in a human ...

Created: 14th May 2012 at 09:40 Last updated: 24th Oct 2013 at 16:16