Virtual Liver SEEK

9 items tagged with 'systemic iron homeostasis'.

Publications (9)

Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload

Authors: Sandro Altamura, Regina Kessler, Hermann-Josef Gröne, Norbert Gretz, Matthias W Hentze, Bruno Galy, Martina U Muckenthaler

PubMed ID: 25100063

Date Published: 8th Aug 2014

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Cell Metab.

Citation: Cell Metab. 20(2): 359-67

Scales: Intercellular, Liver and Organism

Abstract (Expand)

The regulatory axis between the iron hormone hepcidin and its receptor, the iron exporter ferroportin (FPN), is central to iron homeostasis. Mutations preventing hepcidin-mediated degradation of FPN ...

Created: 21st Jan 2015 at 10:21

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3)

Authors: Gunda Millonig, Ingo Ganzleben, Teresa Peccerella, Guillem Casanovas, Lidia Brodziak-Jarosz, Katja Breitkopf-Heinlein, Tobias P Dick, Helmut-Karl Seitz, Martina U Muckenthaler, Sebastian Mueller

PubMed ID: 22932892

Date Published: 29th Aug 2012

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: J. Biol. Chem.

Citation: J. Biol. Chem. 287(44): 37472-82

Scales: Cell

Abstract (Expand)

The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum. During inflammation, hepcidin is strongly induced by ...

Created: 20th Jan 2014 at 11:13

Out of balance--systemic iron homeostasis in iron-related disorders

Authors: Andrea U Steinbicker, Martina U Muckenthaler

PubMed ID: 23917168

Date Published: 7th Aug 2013

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Nutrients

Citation: Nutrients 5(8): 3034-61

Scales: Cell, Intercellular and Organism

Abstract (Expand)

Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency ...

Created: 20th Jan 2014 at 11:06

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

Authors: Katarzyna Mleczko-Sanecka, Guillem Casanovas, Anan Ragab, Katja Breitkopf, Alexandra Müller, Michael Boutros, Steven Dooley, Matthias W Hentze, Martina U Muckenthaler

PubMed ID: 20040761

Date Published: 29th Dec 2009

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Blood

Citation: Blood 115(13): 2657-65

Scales: Not specified

Abstract (Expand)

Hepcidin is the master regulatory hormone of systemic iron metabolism. Hepcidin deficiency causes common iron overload syndromes whereas its overexpression is responsible for microcytic anemias. Hepcidin ...

Created: 30th Oct 2012 at 08:51 Last updated: 24th Oct 2013 at 16:21

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

Authors: Maja Vujić Spasić, Richard Sparla, Katarzyna Mleczko-Sanecka, Mary C Migas, Katja Breitkopf-Heinlein, Steven Dooley, Sophie Vaulont, Robert E Fleming, Martina U Muckenthaler

PubMed ID: 22960056

Date Published: 11th Sep 2012

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., Show cases

Journal: Biochim. Biophys. Acta

Citation: Biochim. Biophys. Acta 1832(1): 76-84

Scales: Not specified

Abstract (Expand)

The inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of systemic iron homeostasis. In this study we define the mRNA expression of the two functionally related Smad proteins, ...

Created: 31st Oct 2012 at 09:07 Last updated: 24th Oct 2013 at 16:15

Two to tango: regulation of Mammalian iron metabolism

Authors: Matthias W Hentze, Martina U Muckenthaler, Bruno Galy, Clara Camaschella

PubMed ID: 20603012

Date Published: 7th Jul 2010

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys

Journal: Cell

Citation: Cell 142(1): 24-38

Scales: Cell

Abstract (Expand)

Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions ...

Created: 29th Oct 2012 at 11:04 Last updated: 24th Oct 2013 at 16:20

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways

Authors: Katarzyna Mleczko-Sanecka, Franziska Roche, Ana Rita da Silva, Debora Call, Flavia D'Alessio, Anan Ragab, Philip E Lapinski, Ramesh Ummanni, Ulrike Korf, Christopher Oakes, Georg Damm, Lorenza A D'Alessandro, Ursula Klingmüeller, Philip D King, Michael Boutros, Matthias W Hentze, Martina U Muckenthaler

PubMed ID: 24385536

Date Published: 5th Jan 2014

Projects: A3.4: Linking signalling to metabolic functions, B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Blood

Citation: Blood :

Scales: Cell and Intercellular

Abstract (Expand)

The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression is largely regulated by two signaling pathways, the 'iron-regulated' bone morphogenetic protein ...

Created: 14th Jan 2014 at 12:06

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis

Authors: Guillem Casanovas, Anashua Banerji, Flavia d'Alessio, Martina U Muckenthaler, Stefan Legewie

PubMed ID: 24391488

Date Published: 2nd Jan 2014

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: PLoS Comput. Biol.

Citation: PLoS Comput. Biol. 10(1): e1003421

Scales: Cell

Abstract (Expand)

Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated ...

Created: 14th Jan 2014 at 11:56

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

Authors: Mirco Castoldi, Maja Vujic Spasic, Sandro Altamura, Joacim Elmén, Morten Lindow, Judit Kiss, Jens Stolte, Richard Sparla, Lorenza A D'Alessandro, Ursula Klingmüller, Robert E Fleming, Thomas Longerich, Hermann J Gröne, Vladimir Benes, Sakari Kauppinen, Matthias W Hentze, Martina U Muckenthaler

PubMed ID: 21364282

Date Published: 3rd Mar 2011

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: J. Clin. Invest.

Citation: J. Clin. Invest. 121(4): 1386-96

Scales: Cell, Liver and Organism

Abstract (Expand)

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. ...

Created: 11th Jul 2012 at 10:47 Last updated: 24th Oct 2013 at 16:19