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Assays (1)
ID: 70
Biological problem addressed: Gene regulatory network
Investigation: 1 hidden item
Study: 1 hidden item
Models: 4 hidden items
Contributor: Sebastian Vlaic
Projects: A: Cellular level
Organisms: Not Specified
SOPs: No SOPs
Data files: GRN2SBML Bundle
Scales: Cell
Created: 1st Nov 2013 at 10:42  Last updated: 24th Jul 2015 at 13:29
Data files (3)
Uploader: Bruno Christ
Contributor: Bruno Christ
Other contributors: Not specified
Version: 1
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Scales: Liver
Created: 12th Feb 2014 at 16:15  Last updated: 11th Jan 2016 at 08:48
Uploader: Matthias König
Contributor: Matthias König
Other contributors: Not specified
Version: 1
Projects: A: Cellular level
Scales: Not specified
Experimental data digitized from publication figure.
Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals.
Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, Havel PJ.
Am J Clin Nutr. 2008 May;87(5):1194-203.
PMID: 18469239
http://www.ncbi.nlm.nih.gov/pubmed/18469239
Created: 30th Jun 2015 at 07:18
Uploader: Bruno Christ
Contributor: Bruno Christ
Other contributors: Not specified
Version: 1
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Scales: Liver
Created: 12th Feb 2014 at 16:18  Last updated: 11th Jan 2016 at 08:50
SOPs (1)
Uploader: Bruno Christ
Contributor: Bruno Christ
Other contributors: Peggy Stock, Sabine Ebensing, Madlen Hempel, Matthias M Dollinger
Version: 1
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Scales: Liver lobule
This protocol describes the in vitro differentiation of stem cells from human bone marrow and their transplantation into livers of immunodeficient mice.
Created: 24th Oct 2012 at 10:34
Publications (352)
Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse
Authors: J. Zhang, K. He, L. Cai, Y. C. Chen, Y. Yang, Q. Shi, T. F. Woolf, W. Ge, L. Guo, J. Borlak, W. Tong
PubMed ID: 27000539
Date Published: 24th Mar 2016
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Chem Biol Interact
Citation: Chem Biol Interact. 2016 Mar 19. pii: S0009-2797(16)30089-8. doi: 10.1016/j.cbi.2016.03.019.
Authors: E. H. Lee, J. H. Oh, S. Selvaraj, S. M. Park, M. S. Choi, R. Spanel, S. Yoon, J. Borlak
PubMed ID: 26934552
Date Published: 5th Mar 2016
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Oncotarget
Citation: Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7698.
Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades
Authors: Z. Liu, Y. Wang, J. Borlak, W. Tong
PubMed ID: 27045805
Date Published: 6th Apr 2016
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Sci Rep
Citation: Sci Rep. 2016 Apr 5;6:23709. doi: 10.1038/srep23709.
Authors: N. J. Stanford, K. Wolstencroft, M. Golebiewski, R. Kania, N. Juty, C. Tomlinson, S. Owen, S. Butcher, H. Hermjakob, N. Le Novere, W. Mueller, J. Snoep, C. Goble
PubMed ID: 26700851
Date Published: 25th Dec 2015
Projects: F1: The data management system, Virtual Liver
Journal: Mol Syst Biol
Citation: Mol Syst Biol. 2015 Dec 23;11(12):851. doi: 10.15252/msb.20156053.
Scales: Not specified
Abstract:
Created: 8th Jan 2016 at 09:38
Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling
Authors: Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F. Templin, Thomas O. Joos, Wolfgang E. Thasler, Andreas Zell, Ulrich M. Zanger
DOI: 10.1371/journal.pcbi.1004431
Date Published: 4th Jan 2016
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 12(1) : e1004431
Scales: Cell
Abstract (Expand)
Created: 7th Jan 2016 at 15:20  Last updated: 7th Jan 2016 at 15:24
Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles
Authors: J. Zhang, U. Doshi, A. Suzuki, C. W. Chang, J. Borlak, A. P. Li, W. Tong
PubMed ID: 26581450
Date Published: 20th Nov 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Chem Biol Interact
Citation: Chem Biol Interact. 2015 Nov 12. pii: S0009-2797(15)30110-1. doi: 10.1016/j.cbi.2015.11.008.
Authors: M. G. Mooij, A. T. Nies, C. A. Knibbe, E. Schaeffeler, D. Tibboel, M. Schwab, S. N. de Wildt
PubMed ID: 26410689
Date Published: 28th Sep 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacokinet
Citation: Clin Pharmacokinet. 2015 Sep 26.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:53
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
Authors: S. Wolking, E. Schaeffeler, H. Lerche, M. Schwab, A. T. Nies
PubMed ID: 25860377
Date Published: 11th Apr 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacokinet
Citation: Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:51
Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors
Authors: A. Emami Riedmaier, O. Burk, B. A. van Eijck, E. Schaeffeler, K. Klein, S. Fehr, S. Biskup, S. Muller, S. Winter, U. M. Zanger, M. Schwab, A. T. Nies
PubMed ID: 26239079
Date Published: 5th Aug 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Pharmacogenomics J
Citation: Pharmacogenomics J. 2015 Aug 4. doi: 10.1038/tpj.2015.55.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:49
Authors: J. Matthaei, J. Brockmoller, M. V. Tzvetkov, D. Sehrt, C. Sachse-Seeboth, J. B. Hjelmborg, S. Moller, U. Halekoh, U. Hofmann, M. Schwab, R. Kerb
PubMed ID: 26344676
Date Published: 8th Sep 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacol Ther
Citation: Clin Pharmacol Ther. 2015 Sep 7. doi: 10.1002/cpt.258.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:46
Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe
Authors: F. Malentacchi, I. Mancini, I. Brandslund, P. Vermeersch, M. Schwab, J. Marc, R. H. van Schaik, G. Siest, E. Theodorsson, M. Pazzagli, C. Di Resta
PubMed ID: 26036226
Date Published: 4th Jun 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Drug Metabol Personal Ther
Citation: Drug Metabol Personal Ther. 2015 Jun;30(2):121-8. doi: 10.1515/dmdi-2015-0012.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:44
Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant
Authors: R. Arlanov, T. Lang, G. Jedlitschky, E. Schaeffeler, T. Ishikawa, M. Schwab, A. T. Nies
PubMed ID: 25896536
Date Published: 22nd Apr 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Pharmacogenomics J
Citation: Pharmacogenomics J. 2015 Apr 21. doi: 10.1038/tpj.2015.27.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:41
Authors: F. Schreiber, G. D. Bader, M. Golebiewski, M. Hucka, B. Kormeier, N. Le Novere, C. Myers, D. Nickerson, B. Sommer, D. Waltemath, S. Weise
PubMed ID: 26528556
Date Published: 4th Sep 2015
Projects: F1: The data management system, Virtual Liver
Journal: J Integr Bioinform
Citation: J Integr Bioinform. 2015 Sep 4;12(2):258. doi: 10.2390/biecoll-jib-2015-258.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 09:15
Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Authors: H. Stark, M. Fichtner, R. Konig, S. Lorkowski, S. Schuster
PubMed ID: 26382968
Date Published: 14th Sep 2015
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Biochimie
Citation: Biochimie. 2015 Nov;118:185-94. doi: 10.1016/j.biochi.2015.09.017. Epub 2015 Sep 14.
Authors: M. Bartl, M. Pfaff, A. Ghallab, D. Driesch, S. G. Henkel, J. G. Hengstler, S. Schuster, C. Kaleta, R. Gebhardt, S. Zellmer, P. Li
PubMed ID: 26438405
Date Published: 5th Oct 2015
Projects: C3: Zonation of metabolism and its regulation
Journal: Arch Toxicol
Citation: Arch Toxicol. 2015 Nov;89(11):2069-78. doi: 10.1007/s00204-015-1596-4. Epub 2015 Oct 5.
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 11th Dec 2015 at 09:07
Authors: Stefan Ohrnberger, Abhishek Thavamani, Albert Braeuning, Daniel B. Lipka, Milen Kirilov, Robert Geffers, Stella E. Authenrieth, Michael Römer, Andreas Zell, Michael Bonin, Michael Schwarz, Günther Schütz, Peter Schirmacher, Christoph Plass, Thomas Longerich, Alfred Nordheim
DOI: 10.1002/hep.27539
Date Published: 1st Mar 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Hepatology
Citation: Hepatology 61(3) : 979
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 14th Dec 2015 at 15:12  Last updated: 14th Dec 2015 at 15:15
Authors: K. Abshagen, M. Konig, A. Hoppe, I. Muller, M. Ebert, H. Weng, H. G. Holzhutter, U. M. Zanger, J. Bode, B. Vollmar, M. Thomas, S. Dooley
PubMed ID: 26589287
Date Published: 20th Nov 2015
Projects: A1: Cellular metabolism, A2: Integration of Signalling Pathways in Hepatocellular Response, A3: Crosslinking signalling metabolism and hepatocyte polarisation, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level, D: Whole organ level
Journal: BMC Syst Biol
Citation: BMC Syst Biol. 2015 Nov 20;9(1):83.
Scales: Cell, Liver lobule and Liver
Abstract (Expand)
Created: 23rd Nov 2015 at 07:41
Authors: Nadinath B. Nillegoda, Janine Kirstein, Anna Szlachcic, Mykhaylo Berynskyy, Antonia Stank, Florian Stengel, Kristin Arnsburg, Xuechao Gao, Annika Scior, Ruedi Aebersold, D. Lys Guilbride, Rebecca C. Wade, Richard I. Morimoto, Matthias P. Mayer, Bernd Bukau
DOI: 10.1038/nature14884
Date Published: 5th Aug 2015
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Nature
Citation: Nature 524(7564) : 247
Scales: Organism
Abstract (Expand)
Created: 18th Sep 2015 at 13:35  Last updated: 18th Sep 2015 at 13:41
Authors: Xiaofeng Yu, Michael Martinez, Annika L. Gable, Jonathan C. Fuller, Neil J. Bruce, Stefan Richter, Rebecca C. Wade
DOI: 10.1093/nar/gkv335
Date Published: 30th Jun 2015
Projects: F3: Kinetic data handling
Journal: Nucleic Acids Res
Citation: Nucleic Acids Res 43(W1) : W220
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 13:33  Last updated: 18th Sep 2015 at 13:34
Authors: Julia Romanowska, Daria B. Kokh, Jonathan C. Fuller, Rebecca C. Wade
DOI: 10.1002/9783527673025.ch11
Date Published: 11th May 2015
Projects: F3: Kinetic data handling
Book: Thermodynamics and Kinetics of Drug Binding
Citation: Methods and Principles in Medicinal Chemistry : 211
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 13:23  Last updated: 18th Sep 2015 at 13:26
Authors: Michael Martinez, Neil J. Bruce, Julia Romanowska, Daria B. Kokh, Musa Ozboyaci, Xiaofeng Yu, Mehmet Ali Öztürk, Stefan Richter, Rebecca C. Wade
DOI: 10.1002/jcc.23971
Date Published: 5th Aug 2015
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: J. Comput. Chem.
Citation: J. Comput. Chem. 36(21) : 1631
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 11:12  Last updated: 18th Sep 2015 at 12:36
The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates proliferative and pro-inflammatory genes
Authors: M. Thomas, C. Bayha, K. Klein, S. Muller, T. S. Weiss, M. Schwab, U. M. Zanger
PubMed ID: 26122096
Date Published: 30th Jun 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Cancer
Citation: BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x.
Scales: Not specified
Abstract (Expand)
Created: 17th Sep 2015 at 10:19
LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods
Authors: R. Feuer, S. Vlaic, J. Arlt, O. Sawodny, U. Dahmen, U. M. Zanger, M. Thomas
PubMed ID: 26325269
Date Published: 1st Sep 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase LPS and Inflammation
Journal: PLoS One
Citation: PLoS One. 2015 Sep 1;10(9):e0135852. doi: 10.1371/journal.pone.0135852. eCollection 2015.
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: CYP Expression and Induction by Nuclear Receptor Agonists
Authors: A. Braeuning, M. Thomas, U. Hofmann, S. Vetter, E. Zeller, B. Petzuch, J. Johanning, W. Schroth, T. S. Weiss, U. M. Zanger, M. Schwarz
PubMed ID: 26310804
Date Published: 28th Aug 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Drug Metab Dispos
Citation: Drug Metab Dispos. 2015 Aug 26. pii: dmd.115.064667.
Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists
Authors: L. Shi, L. Jong, U. Wittig, P. Lucarelli, M. Stepath, S. Mueller, L. A. D'Alessandro, U. Klingmuller, W. Muller
PubMed ID: 23549603
Date Published: 3rd Apr 2013
Projects: F1: The data management system
Journal: J Integr Bioinform
Citation: J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.
Scales: Not specified
Abstract (Expand)
Created: 7th Aug 2015 at 12:16
Authors: K. Wolstencroft, S. Owen, O. Krebs, Q. Nguyen, N. J. Stanford, M. Golebiewski, A. Weidemann, M. Bittkowski, L. An, D. Shockley, J. L. Snoep, W. Mueller, C. Goble
PubMed ID: 26160520
Date Published: 11th Jul 2015
Projects: F1: The data management system, Virtual Liver
Journal: BMC Syst Biol
Citation: BMC Syst Biol. 2015 Jul 11;9:33. doi: 10.1186/s12918-015-0174-y.
Scales: Not specified
Abstract (Expand)
Created: 7th Aug 2015 at 11:48
Authors: Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, María Matilde Bartolomé Rodríguez, Lars Kuepfer, Tobias Preusser
DOI: 10.1371/journal.pone.0133653
Date Published: 29th Jul 2015
Projects: C1: The role of blood flow in liver lobule function and morphology, D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: PLoS ONE
Citation: PLoS ONE 10(7) : e0133653
Scales: Cell, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 30th Jul 2015 at 09:09  Last updated: 30th Jul 2015 at 09:13
Comparative analysis of TGF-beta/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines
Authors: J. Dzieran, J. Fabian, T. Feng, C. Coulouarn, I. Ilkavets, A. Kyselova, K. Breuhahn, S. Dooley, N. M. Meindl-Beinker
PubMed ID: 23991075
Date Published: 22nd Aug 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS One
Citation: PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252. eCollection 2013.
Scales: Not specified
Abstract (Expand)
Created: 27th Jul 2015 at 07:19
TFpredict and SABINE: Sequence-Based Prediction of Structural and Functional Characteristics of Transcription Factors
Authors: Johannes Eichner, Florian Topf, Andreas Dräger, Clemens Wrzodek, Dierk Wanke, Andreas Zell
DOI: 10.1371/journal.pone.0082238
Date Published: 12th Dec 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS ONE
Citation: PLoS ONE 8(12) : e82238
Scales: Cell and Intercellular
Abstract (Expand)
Created: 17th Nov 2015 at 12:27  Last updated: 17th Nov 2015 at 12:28
Authors: Andreas Dräger, Daniel C Zielinski, Roland Keller, Matthias Rall, Johannes Eichner, Bernhard O Palsson, Andreas Zell
DOI: 10.1186/s12918-015-0212-9
Date Published: 1st Dec 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 9(1) : 389
Scales: Cell and Intercellular
Abstract (Expand)
Created: 16th Nov 2015 at 15:27  Last updated: 16th Nov 2015 at 15:29
Authors: Johannes Eichner, Yvonne Heubach, Manuel Ruff, Hella Kohlhof, Stefan Strobl, Barbara Mayer, Michael Pawlak, Markus F. Templin, Andreas Zell
DOI: 10.1016/j.biosystems.2014.06.009
Date Published: 1st Aug 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Biosystems
Citation: Biosystems 122 : 19
Scales: Cell and Intercellular
Abstract (Expand)
Created: 17th Nov 2015 at 12:14  Last updated: 17th Nov 2015 at 12:15
Mouse white adipose tissue-derived mesenchymal stem cells gain pericentral and periportal hepatocyte features after differentiation in vitro, which are preserved in vivo after hepatic transplantation
Authors: S. Winkler, M. Hempel, S. Bruckner, F. Mallek, A. Weise, T. Liehr, H. M. Tautenhahn, M. Bartels, B. Christ
PubMed ID: 26235702
Date Published: 19th Aug 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Acta Physiol (Oxf)
Citation: Acta Physiol (Oxf). 2015 Oct;215(2):89-104. doi: 10.1111/apha.12560. Epub 2015 Aug 19.
Scales: Liver lobule
Abstract (Expand)
Created: 11th Nov 2015 at 11:22
Authors: B. Christ, S. Bruckner, S. Winkler
PubMed ID: 26476857
Date Published: 22nd Oct 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Trends Mol Med
Citation: Trends Mol Med. 2015 Nov;21(11):673-86. doi: 10.1016/j.molmed.2015.09.004. Epub 2015 Oct 22.
Authors: M. Hempel, A. Schmitz, S. Winkler, O. Kucukoglu, S. Bruckner, C. Niessen, B. Christ
PubMed ID: 25687506
Date Published: 17th Feb 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Cell Mol Life Sci
Citation: Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.
Scales: Liver lobule
Abstract (Expand)
Created: 11th Nov 2015 at 11:12
Authors: Adriano Henney, Peter Hunter, Andrew McCulloch, Denis Noble
DOI: 10.1016/j.pbiomolbio.2015.03.001
Date Published: 2015
Projects: No Projects
Journal: Progress in Biophysics and Molecular Biology
Citation: Progress in Biophysics and Molecular Biology 117(1) : 1
Scales: Not specified
Abstract:
Created: 6th Apr 2015 at 12:20  Last updated: 6th Apr 2015 at 12:21
Authors: Christoph Meyer, Roman Liebe, Katja Breitkopf-Heinlein, Yan Liu, Alexandra Müller, Pia Rakoczy, Maria Thomas, Honglei Weng, Anastasia Bachmann, Matthias Ebert, Steven Dooley
PubMed ID: 25982745
Date Published: 20th May 2015
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A3.3: Hepatocyte polarity
Journal: Differentiation
Citation: Differentiation :
Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes
Authors: Titus Sparna, Julia Rétey, Kathrin Schmich, Ute Albrecht, Katrin Naumann, Norbert Gretz, Hans-Peter Fischer, Johannes G Bode, Irmgard Merfort
PubMed ID: 20374638
Date Published: 7th Apr 2010
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., HepatoSys
Journal: BMC Genomics
Citation: BMC Genomics 11: 226
Scales: Cell
Abstract (Expand)
Created: 30th Aug 2012 at 12:22  Last updated: 24th Oct 2013 at 16:20
Authors: Beate Fuchs, Rosmarie Süss, Jürgen Schiller
PubMed ID: 20643161
Date Published: 25th Apr 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Prog. Lipid Res.
Citation: Prog. Lipid Res. 49(4): 450-75
Scales: Not specified
Abstract (Expand)
Created: 23rd Jun 2011 at 17:13  Last updated: 24th Oct 2013 at 16:20
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
Authors: Stefan Hoehme, Marc Brulport, Alexander Bauer, Essam Bedawy, Wiebke Schormann, Matthias Hermes, Verena Puppe, Rolf Gebhardt, Sebastian Zellmer, Michael Schwarz, Ernesto Bockamp, Tobias Timmel, Jan G Hengstler, Dirk Drasdo
PubMed ID: 20484673
Date Published: 19th May 2010
Projects: B: Communication of Hepatocytes and Non-Parenchymal Liver Cells
Journal: Proc. Natl. Acad. Sci. U.S.A.
Citation: Proc. Natl. Acad. Sci. U.S.A. 107(23): 10371-6
Scales: Liver lobule
Abstract (Expand)
Created: 14th Aug 2012 at 08:44  Last updated: 24th Oct 2013 at 16:20
Authors: Irina Nazarenko, Marcel Jenny, Jana Keil, Cornelia Gieseler, Karen Weisshaupt, Jalid Sehouli, Stefan Legewie, Lena Herbst, Wilko Weichert, Silvia Darb-Esfahani, Manfred Dietel, Reinhold Schäfer, Florian Ueberall, Christine Sers
PubMed ID: 20501645
Date Published: 25th May 2010
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Mol. Cancer Res.
Citation: Mol. Cancer Res. 8(6): 919-34
Scales: Cell
Abstract (Expand)
Created: 11th Sep 2012 at 11:39  Last updated: 24th Oct 2013 at 16:20
Authors: Kristian Rother, Sabrina Hoffmann, Sascha Bulik, Andreas Hoppe, Johann Gasteiger, Herrmann-Georg Holzhütter
PubMed ID: 20513391
Date Published: 2nd Jun 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Biophys. J.
Citation: Biophys. J. 98(11): 2478-86
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 10:51  Last updated: 24th Oct 2013 at 16:20
Authors: Edda Klipp, Rebecca C Wade, Ursula Kummer
PubMed ID: 20554441
Date Published: 14th Jun 2010
Scales: Not specified
Abstract (Expand)
Created: 30th Aug 2012 at 13:17  Last updated: 24th Oct 2013 at 16:20
Authors: Matthias König, Hermann-Georg Holzhütter
PubMed ID: 22081592
Date Published: 1st Jul 2010
Projects: No Projects
Journal: Genome Inform
Citation: Genome Inform 24(1): 96-103
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 11:14  Last updated: 24th Oct 2013 at 16:20
Authors: Guoguang Sun, Dana Maria Rosu, Xin Zhang, Marc Hovestädt, Simona Pop, Ulrich Schade, Dennis Aulich, Michael Gensch, Bernhard Ay, Hermann-Georg Holzhütter, Dietrich R. T. Zahn, Norbert Esser, Rudolf Volkmer, Jörg Rappich, Karsten Hinrichs
Date Published: 1st Aug 2010
Projects: No Projects
Journal: phys. stat. sol. (b)
Citation: phys. stat. sol. (b) 247(8) : 1925
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 12:51  Last updated: 24th Oct 2013 at 16:20
Authors: Bruno Galy, Dunja Ferring-Appel, Sven W Sauer, Sylvia Kaden, Saïd Lyoumi, Herve Puy, Stefan Kölker, Hermann-Josef Gröne, Matthias W Hentze
PubMed ID: 20674864
Date Published: 3rd Aug 2010
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys
Journal: Cell Metab.
Citation: Cell Metab. 12(2): 194-201
Scales: Cell
Abstract (Expand)
Created: 29th Oct 2012 at 11:00  Last updated: 24th Oct 2013 at 16:20
Authors: Stefan Hoehme, Dirk Drasdo
PubMed ID: 20709692
Date Published: 13th Aug 2010
Projects: No Projects
Journal: Bioinformatics
Citation: Bioinformatics 26(20): 2641-2
Scales: Not specified
Abstract (Expand)
Created: 10th Sep 2012 at 17:45  Last updated: 24th Oct 2013 at 16:19
Authors: Tiago J S Lopes, Tatyana Luganskaja, Maja Vujić Spasić, Matthias W Hentze, Martina U Muckenthaler, Klaus Schümann, Jens G Reich
PubMed ID: 20704761
Date Published: 13th Aug 2010
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: BMC Syst Biol
Citation: BMC Syst Biol 4: 112
Scales: Organism
Abstract (Expand)
Created: 19th Jul 2012 at 11:25  Last updated: 24th Oct 2013 at 16:19
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
Authors: Carola Huthmacher, Andreas Hoppe, Sascha Bulik, Hermann-Georg Holzhütter
PubMed ID: 20807400
Date Published: 31st Aug 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: BMC Syst Biol
Citation: BMC Syst Biol 4: 120
Scales: Cell
Abstract (Expand)
Created: 4th Jan 2013 at 10:50  Last updated: 24th Oct 2013 at 16:19
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice
Authors: Albert Braeuning, Yasmin Singh, Benjamin Rignall, Albrecht Buchmann, Seddik Hammad, Amnah Othman, Iris von Recklinghausen, Patricio Godoy, Stefan Hoehme, Dirk Drasdo, Jan G Hengstler, Michael Schwarz
PubMed ID: 20886225
Date Published: 1st Oct 2010
Projects: No Projects
Journal: Histochem. Cell Biol.
Citation: Histochem. Cell Biol. 134(5): 469-81
Scales: Not specified
Abstract (Expand)
Created: 10th Sep 2012 at 17:18  Last updated: 24th Oct 2013 at 16:19
Authors: Elke Ueberham, Jan Böttger, Uwe Ueberham, Jens Grosche, Rolf Gebhardt
PubMed ID: 20942944
Date Published: 13th Oct 2010
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level
Journal: Comp Hepatol
Citation: Comp Hepatol 9: 8
Scales: Cell, Intercellular, Liver lobule and Liver
Abstract (Expand)
Created: 20th Jul 2012 at 10:16  Last updated: 24th Oct 2013 at 16:19
Automated extraction of DNA and RNA from a single formalin-fixed paraffin-embedded tissue section for analysis of both single-nucleotide polymorphisms and mRNA expression
Authors: Guido Hennig, Mathias Gehrmann, Udo Stropp, Hiltrud Brauch, Peter Fritz, Michel Eichelbaum, Matthias Schwab, Werner Schroth
PubMed ID: 20947696
Date Published: 14th Oct 2010
Projects: No Projects
Journal: Clin. Chem.
Citation: Clin. Chem. 56(12): 1845-53
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 12:20  Last updated: 24th Oct 2013 at 16:19
Authors: Beate Fuchs, Rosmarie Süss, Kristin Teuber, Mandy Eibisch, Jürgen Schiller
PubMed ID: 21167493
Date Published: 14th Oct 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: J Chromatogr A
Citation: J Chromatogr A 1218(19): 2754-74
Scales: Not specified
Abstract (Expand)
Created: 23rd Jun 2011 at 17:18  Last updated: 24th Oct 2013 at 16:19
Authors: Andreas Hoppe, Sabrina Hoffmann, Andreas Gerasch, Christoph Gille, Hermann-Georg Holzhütter
PubMed ID: 21255455
Date Published: 22nd Oct 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 12: 28
Scales: Not specified
Abstract (Expand)
Created: 7th Feb 2011 at 12:27  Last updated: 24th Oct 2013 at 16:19
HMMerThread: detecting remote, functional conserved domains in entire genomes by combining relaxed sequence-database searches with fold recognition
Authors: Charles Richard Bradshaw, Vineeth Surendranath, Robert Henschel, Matthias Stefan Mueller, Bianca Hermine Habermann
PubMed ID: 21423752
Date Published: 16th Nov 2010
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: PLoS ONE
Citation: PLoS ONE 6(3): e17568
Scales: Not specified
Abstract (Expand)
Created: 24th Jun 2011 at 16:19  Last updated: 24th Oct 2013 at 16:19
Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets
Authors: Valentina Raia, Marcel Schilling, Martin Böhm, Bettina Hahn, Andreas Kowarsch, Andreas Raue, Carsten Sticht, Sebastian Bohl, Maria Saile, Peter Möller, Norbert Gretz, Jens Timmer, Fabian Theis, Wolf-Dieter Lehmann, Peter Lichter, Ursula Klingmüller
PubMed ID: 21127196
Date Published: 2nd Dec 2010
Scales: Not specified
Abstract (Expand)
Created: 10th Aug 2012 at 09:41  Last updated: 24th Oct 2013 at 16:19
Sphingomyelin is more sensitively detectable as a negative ion than phosphatidylcholine: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study using 9-aminoacridine (9-AA) as matrix
Authors: Mandy Eibisch, Jürgen Schiller
PubMed ID: 21452388
Date Published: 15th Dec 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Rapid Commun. Mass Spectrom.
Citation: Rapid Commun. Mass Spectrom. 25(8): 1100-6
Scales: Not specified
Abstract (Expand)
Created: 23rd Jun 2011 at 17:22  Last updated: 24th Oct 2013 at 16:19
Author: Alison Abbott
PubMed ID: 21164453
Date Published: 18th Dec 2010
Scales: Not specified
Abstract:
Created: 3rd Mar 2011 at 14:11  Last updated: 24th Oct 2013 at 16:19
Authors: A Raue, V Becker, U Klingmüller, J Timmer
PubMed ID: 21198117
Date Published: 5th Jan 2011
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Chaos
Citation: Chaos 20(4): 045105
Scales: Cell
Abstract (Expand)
Created: 10th Aug 2012 at 09:43  Last updated: 24th Oct 2013 at 16:19
Authors: Christa Buechler, Thomas S Weiss
PubMed ID: 21222589
Date Published: 13th Jan 2011
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Curr. Drug Metab.
Citation: Curr. Drug Metab. 12(1): 24-34
The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model
Authors: Nikolaus Berndt, Sabrina Hoffmann, Jan Benda, Hermann-Georg Holzhütter
PubMed ID: 21295041
Date Published: 2nd Feb 2011
Projects: No Projects
Journal: J. Theor. Biol.
Citation: J. Theor. Biol. 276(1): 42-9
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 11:22  Last updated: 24th Oct 2013 at 16:19
ABCB1 single-nucleotide polymorphisms determine tacrolimus response in patients with ulcerative colitis
Authors: K R Herrlinger, H Koc, S Winter, A Teml, E F Stange, K Fellermann, P Fritz, M Schwab, E Schaeffeler
PubMed ID: 21289623
Date Published: 2nd Feb 2011
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting
Journal: Clin. Pharmacol. Ther.
Citation: Clin. Pharmacol. Ther. 89(3): 422-8
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 12:30  Last updated: 24th Oct 2013 at 16:19
Authors: L T Joeckel, R Wallich, P Martin, D Sanchez-Martinez, F C Weber, S F Martin, C Borner, J Pardo, C Froelich, M M Simon
PubMed ID: 21311565
Date Published: 11th Feb 2011
Projects: No Projects
Journal: Cell Death Differ.
Citation: Cell Death Differ. 18(7): 1112-9
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:28
Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions
Authors: Katrin Luckert, Frank Götschel, Peter K Sorger, Andreas Hecht, Thomas O Joos, Oliver Pötz
PubMed ID: 21378377
Date Published: 4th Mar 2011
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.2: Importance of Wnt- and Hedgehog factors for hepatic stellate cells...
Journal: Mol. Cell Proteomics
Citation: Mol. Cell Proteomics 10(5): M110.007377
Scales: Cell
Abstract (Expand)
Created: 13th Sep 2012 at 13:58  Last updated: 24th Oct 2013 at 16:19
Authors: A Raue, C Kreutz, T Maiwald, U Klingmuller, J Timmer
PubMed ID: 21405200
Date Published: 17th Mar 2011
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: IET Syst Biol
Citation: IET Syst Biol 5(2): 120-30
Scales: Cell and Intercellular
Abstract (Expand)
Created: 18th Jul 2012 at 09:24  Last updated: 24th Oct 2013 at 16:18
Authors: Andreas K Nussler, Katrin Zeilinger, Lilianna Schyschka, Sabrina Ehnert, Jörg C Gerlach, Xueying Yan, Serene M L Lee, Maren Ilowski, Wolfgang E Thasler, Thomas S Weiss
PubMed ID: 21461918
Date Published: 3rd Apr 2011
Projects: CTU SOP Human Hepatocytes, HepatoSys
Journal: J Mater Sci Mater Med
Citation: J Mater Sci Mater Med 22(5): 1087-99
Authors: Beate Fuchs, Rosmarie Süß, Kristin Teuber, Mandy Eibisch, Jürgen Schiller
DOI: 10.1016/j.chroma.2010.11.066
Date Published: 1st May 2011
Projects: No Projects
Journal: Journal of Chromatography A
Citation: Journal of Chromatography A 1218(19) : 2754
Scales: Not specified
Abstract (Expand)
Created: 4th Aug 2012 at 16:19  Last updated: 24th Oct 2013 at 16:18
A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes
Authors: Joachim Bucher, Stephan Riedmaier, Anke Schnabel, Katrin Marcus, Gabriele Vacun, Thomas S Weiss, Wolfgang E Thasler, Andreas K Nüssler, Ulrich M Zanger, Matthias Reuss
PubMed ID: 21548957
Date Published: 6th May 2011
Projects: A3.4: Linking signalling to metabolic functions
Journal: BMC Syst Biol
Citation: BMC Syst Biol 5: 66
Scales: Not specified
Abstract (Expand)
Created: 31st Jan 2012 at 11:59  Last updated: 24th Oct 2013 at 16:18
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3
Authors: Christian Ehlting, Natalia Ronkina, Oliver Böhmer, Ute Albrecht, Konrad A Bode, Karl S Lang, Alexey Kotlyarov, Danuta Radzioch, Matthias Gaestel, Dieter Häussinger, Johannes G Bode
PubMed ID: 21586572
Date Published: 17th May 2011
Projects: B1.1: Differential communication of wound healing and hepatoxic macropha..., B1.2: Reciprocal effect of cell-cell communication on information proces...
Journal: J. Biol. Chem.
Citation: J. Biol. Chem. 286(27): 24113-24
Scales: Cell
Abstract (Expand)
Created: 31st Aug 2012 at 11:46  Last updated: 24th Oct 2013 at 16:18
Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development
Authors: Malte Paulsen, Stefan Legewie, Roland Eils, Emil Karaulanov, Christof Niehrs
PubMed ID: 21633009
Date Published: 1st Jun 2011
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Proc. Natl. Acad. Sci. U.S.A.
Citation: Proc. Natl. Acad. Sci. U.S.A. 108(25): 10202-7
Scales: Cell
Abstract (Expand)
Created: 11th Sep 2012 at 11:36  Last updated: 24th Oct 2013 at 16:18
Authors: A. Bischoff, M. Eibisch, B. Fuchs, R. Süss, M. Schürenberg, D. Suckau, J. Schiller
DOI: 10.1556/AChrom.23.2011.2.13
Date Published: 1st Jun 2011
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Acta Chromatographica
Citation: Acta Chromatographica 23(2) : 365
Scales: Not specified
Abstract (Expand)
Created: 23rd Jun 2011 at 17:24  Last updated: 24th Oct 2013 at 16:18
Authors: Frank A. Schildberg, Alexandra Wojtalla, Sören V. Siegmund, Elmar Endl, Linda Diehl, Zeinab Abdullah, Christian Kurts, Percy A. Knolle
DOI: 10.1002/hep.24352
Date Published: 1st Jul 2011
Projects: B4: Regulation of pro-inflammatory stimuli through communication of live...
Journal: Hepatology
Citation: Hepatology 54(1) : 262
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 17:12  Last updated: 24th Oct 2013 at 16:18
Authors: Mara Monetti, Nagarjuna Nagaraj, Kirti Sharma, Matthias Mann
PubMed ID: 21743459
Date Published: 10th Jul 2011
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., C5: Structural changes and functional consequences of the liver lobular/..., HepatoSys
Journal: Nat. Methods
Citation: Nat. Methods 8(8): 655-8
Scales: Not specified
Abstract (Expand)
Created: 30th Jul 2012 at 13:35  Last updated: 24th Oct 2013 at 16:18
Authors: Anne T Nies, Ute Hofmann, Claudia Resch, Elke Schaeffeler, Maria Rius, Matthias Schwab
PubMed ID: 21779389
Date Published: 14th Jul 2011
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting
Journal: PLoS ONE
Citation: PLoS ONE 6(7): e22163
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 13:31  Last updated: 24th Oct 2013 at 16:18
Authors: Christoph Kaleta, Luís F de Figueiredo, Sarah Werner, Reinhard Guthke, Michael Ristow, Stefan Schuster
PubMed ID: 21814506
Date Published: 21st Jul 2011
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 08:43  Last updated: 24th Oct 2013 at 16:18
Authors: Katrin Hübner, Sven Sahle, Ursula Kummer
PubMed ID: 21707921
Date Published: 26th Jul 2011
Scales: Cell
Abstract (Expand)
Created: 30th Aug 2012 at 13:14  Last updated: 24th Oct 2013 at 16:18
Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis
Authors: Stephan Riedmaier, Kathrin Klein, Stefan Winter, Ute Hofmann, Matthias Schwab, Ulrich M Zanger
PubMed ID: 21852972
Date Published: 27th Jul 2011
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Front Pharmacol
Citation: Front Pharmacol 2: 41
Scales: Cell
Abstract (Expand)
Created: 27th Jun 2012 at 16:05  Last updated: 24th Oct 2013 at 16:18
Authors: Christoph Gille, Katrin Hübner, Andreas Hoppe, Hermann-Georg Holzhütter
PubMed ID: 21824972
Date Published: 8th Aug 2011
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., F2: The Liver Knowledge Base (LKB)
Journal: Bioinformatics
Citation: Bioinformatics 27(19): 2763-4
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 10:45  Last updated: 24th Oct 2013 at 16:18
Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor
Authors: Anna Dittrich, Christina Khouri, Sara Dutton Sackett, Christian Ehlting, Oliver Böhmer, Ute Albrecht, Johannes G Bode, Christian Trautwein, Fred Schaper
PubMed ID: 21898505
Date Published: 8th Sep 2011
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Hepatology
Citation: Hepatology 55(1): 256-66
Scales: Cell
Abstract (Expand)
Created: 31st Aug 2012 at 11:45  Last updated: 24th Oct 2013 at 16:17
Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics
Authors: Katja Damme, Anne T Nies, Elke Schaeffeler, Matthias Schwab
PubMed ID: 21923552
Date Published: 17th Sep 2011
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G4: Whole-Body Detoxification in Mouse Models
Journal: Drug Metab. Rev.
Citation: Drug Metab. Rev. 43(4): 499-523
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 13:10  Last updated: 24th Oct 2013 at 16:17
Phosphatidylcholine dimers can be easily misinterpreted as cardiolipins in complex lipid mixtures: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of lipids from hepatocytes
Authors: Mandy Eibisch, Sebastian Zellmer, Rolf Gebhardt, Rosmarie Süss, Beate Fuchs, Jürgen Schiller
PubMed ID: 23657956
Date Published: 30th Sep 2011
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Rapid Commun. Mass Spectrom.
Citation: Rapid Commun. Mass Spectrom. 25(18): 2619-26
Authors: A M M Kober, S Legewie, C Pforr, N Fricker, R Eils, P H Krammer, I N Lavrik
PubMed ID: 21975294
Date Published: 7th Oct 2011
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: Cell Death Dis
Citation: Cell Death Dis 2: e212
Scales: Cell
Abstract (Expand)
Created: 3rd Sep 2012 at 11:25  Last updated: 24th Oct 2013 at 16:17
Authors: Steven Dooley, Peter ten Dijke
PubMed ID: 22006249
Date Published: 19th Oct 2011
Projects: B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., Show cases
Journal: Cell Tissue Res.
Citation: Cell Tissue Res. 347(1): 245-56
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 08:42  Last updated: 24th Oct 2013 at 16:17
Authors: Beate Fuchs, Kristin Bresler, Jürgen Schiller
DOI: 10.1016/j.chemphyslip.2011.09.006
Date Published: 1st Nov 2011
Projects: No Projects
Journal: Chemistry and Physics of Lipids
Citation: Chemistry and Physics of Lipids 164(8) : 782
Scales: Not specified
Abstract (Expand)
Created: 4th Aug 2012 at 16:23  Last updated: 24th Oct 2013 at 16:17
Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling
Authors: Johannes G Bode, Ute Albrecht, Dieter Häussinger, Peter C Heinrich, Fred Schaper
PubMed ID: 22093287
Date Published: 16th Nov 2011
Projects: B1.1: Differential communication of wound healing and hepatoxic macropha..., B1.2: Reciprocal effect of cell-cell communication on information proces..., D2: Dynamics of metabolism, inflammation and ammonia detoxication during..., D3: Inflammation and Regeneration: the whole organ
Journal: Eur. J. Cell Biol.
Citation: Eur. J. Cell Biol. 91(6-7): 496-505
Abstract (Expand)
Created: 31st Aug 2012 at 11:44  Last updated: 24th Oct 2013 at 16:17
Authors: Josef Wanninger, Sabrina Bauer, Kristina Eisinger, Thomas S Weiss, Roland Walter, Claus Hellerbrand, Andreas Schäffler, Akiko Higuchi, Kenneth Walsh, Christa Buechler
PubMed ID: 22118966
Date Published: 18th Nov 2011
Projects: CTU SOP Human Hepatocytes, Show cases
Journal: Mol. Cell. Endocrinol.
Citation: Mol. Cell. Endocrinol. 349(2): 248-54
Authors: Lars Kuepfer, Jörg Lippert, Thomas Eissing
PubMed ID: 22161351
Date Published: 14th Dec 2011
Projects: E4: Vertical integration across biological scales, G: Clinical translation
Journal: Adv. Exp. Med. Biol.
Citation: Adv. Exp. Med. Biol. 736: 543-61
Scales: Organism
Abstract (Expand)
Created: 1st Mar 2012 at 16:42  Last updated: 24th Oct 2013 at 16:17
Authors: C. Mente, I. Prade, L. Brusch, G. Breier, A. Deutsch
DOI: 10.5506/APhysPolBSupp.5.99
Date Published: 20th Dec 2011
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., D4: Regeneration and Liver Size
Journal: Acta Phys. Pol. B
Citation: Acta Phys. Pol. B Proc. Suppl. 5(1) : 99
Scales: Not specified
Abstract (Expand)
Created: 23rd Oct 2012 at 15:55  Last updated: 24th Oct 2013 at 16:17
Authors: Clemens Kreutz, Andreas Raue, Jens Timmer
Date Published: 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: BMC Syst Biol
Citation: BMC Syst Biol 6(1) : 120
Scales: Cell
Abstract:
Created: 29th Oct 2012 at 10:26  Last updated: 24th Oct 2013 at 16:17
Authors: Katja Wegner, Anastasia Bachmann, Jan-Ulrich Schad, Philippe Lucarelli, Sven Sahle, Peter Nickel, Christoph Meyer, Ursula Klingmüller, Steven Dooley, Ursula Kummer
PubMed ID: 22284904
Date Published: 5th Jan 2012
Scales: Cell
Abstract (Expand)
Created: 30th Aug 2012 at 13:08  Last updated: 24th Oct 2013 at 16:17
A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins
Authors: Katrin Luckert, Taranjit S Gujral, Marina Chan, Mark Sevecka, Thomas O Joos, Peter K Sorger, Gavin Macbeath, Oliver Pötz
PubMed ID: 22234610
Date Published: 12th Jan 2012
Scales: Not specified
Abstract (Expand)
Created: 27th Nov 2012 at 13:16  Last updated: 24th Oct 2013 at 16:17
Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes
Authors: Karine Sá Ferreira, Clemens Kreutz, Sabine Macnelly, Karin Neubert, Angelika Haber, Matthew Bogyo, Jens Timmer, Christoph Borner
PubMed ID: 22246639
Date Published: 17th Jan 2012
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: Apoptosis : an international journal on programmed cell death
Citation: Apoptosis 17(5): 503-15
Scales: Not specified
Abstract (Expand)
Created: 20th Mar 2012 at 21:32  Last updated: 24th Oct 2013 at 16:17
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis
Authors: Sven Knüppel, Jorge Esparza-Gordillo, Ingo Marenholz, Hermann-Georg Holzhütter, Anja Bauerfeind, Andreas Ruether, Stephan Weidinger, Young-Ae Lee, Klaus Rohde
PubMed ID: 22284537
Date Published: 27th Jan 2012
Projects: No Projects
Journal: BMC Med. Genet.
Citation: BMC Med. Genet. 13: 8
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 13:03  Last updated: 24th Oct 2013 at 16:17
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling
Authors: Michaela Meyer, Sebastian Schneckener, Bernd Ludewig, Lars Kuepfer, Joerg Lippert
PubMed ID: 22293118
Date Published: 31st Jan 2012
Projects: G: Clinical translation
Journal: Drug Metab. Dispos.
Citation: Drug Metab. Dispos. 40(5): 892-901
Scales: Organism
Abstract (Expand)
Created: 27th Apr 2012 at 10:34  Last updated: 24th Oct 2013 at 16:17
Authors: Johannes G Bode, Christian Ehlting, Dieter Häussinger
PubMed ID: 22330073
Date Published: 4th Feb 2012
Projects: B1.1: Differential communication of wound healing and hepatoxic macropha..., B1.2: Reciprocal effect of cell-cell communication on information proces...
Journal: Cell. Signal.
Citation: Cell. Signal. 24(6): 1185-94
Scales: Cell
Abstract (Expand)
Created: 31st Aug 2012 at 11:41  Last updated: 24th Oct 2013 at 16:17
Pharmacogenomics of Codeine, Morphine, and Morphine-6-Glucuronide: Model-Based Analysis of the Influence of CYP2D6 Activity, UGT2B7 Activity, Renal Impairment, and CYP3A4 Inhibition
Authors: Thomas Eissing, Jörg Lippert, Stefan Willmann
PubMed ID: 22352453
Date Published: 23rd Feb 2012
Projects: E4: Vertical integration across biological scales, G: Clinical translation
Journal: Mol Diagn Ther
Citation: Mol Diagn Ther 16(1): 43-53
Scales: Organism
Abstract (Expand)
Created: 1st Mar 2012 at 16:49  Last updated: 24th Oct 2013 at 16:16
Authors: Thomas Maiwald, Julie Blumberg, Andreas Raue, Stefan Hengl, Marcel Schilling, Sherwin Kb Sy, Verena Becker, Ursula Klingmüller, Jens Timmer
PubMed ID: 22369292
Date Published: 27th Feb 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: BMC Syst Biol
Citation: BMC Syst Biol 6: 13
Scales: Cell
Abstract:
Created: 10th Aug 2012 at 09:33  Last updated: 24th Oct 2013 at 16:16
Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells
Authors: Rudolf Arlanov, Andrew Porter, Dennis Strand, Rachel Brough, Darja Karpova, Reinhold Kerb, Leszek Wojnowski, Matthias Schwab, Thomas Lang
PubMed ID: 22290738
Date Published: 28th Feb 2012
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting
Journal: Hum. Mutat.
Citation: Hum. Mutat. 33(4): 750-62
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 13:34  Last updated: 24th Oct 2013 at 16:16
Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics
Authors: Irina Surovtsova, Natalia Simus, Katrin Hübner, Sven Sahle, Ursula Kummer
PubMed ID: 22390191
Date Published: 5th Mar 2012
Scales: Cell
Abstract (Expand)
Created: 30th Aug 2012 at 13:03  Last updated: 24th Oct 2013 at 16:16
Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential
Authors: Juandy Jo, Bertram Bengsch, Bianca Seigel, Sibylle J Rau, Julia Schmidt, Emmanuel Bisse, Peter Aichele, Ulrike Aichele, Lars Joeckel, Cathy Royer, Karine Sá Ferreira, Christoph Borner, Thomas F Baumert, Hubert E Blum, Volker Lohmann, Richard Fischer, Robert Thimme
PubMed ID: 22425625
Date Published: 14th Mar 2012
Projects: No Projects
Journal: J. Hepatol.
Citation: J. Hepatol. 57(1): 9-16
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:20
Authors: Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn
PubMed ID: 22446689
Date Published: 21st Mar 2012
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga...
Journal: J. Hepatol.
Citation: J. Hepatol. 57(1): 186-95
Scales: Not specified
Abstract (Expand)
Created: 16th Jan 2013 at 09:04  Last updated: 24th Oct 2013 at 16:16
Authors: Arian Emami Riedmaier, Anne T Nies, Elke Schaeffeler, Matthias Schwab
PubMed ID: 22457399
Date Published: 28th Mar 2012
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting
Journal: Pharmacol. Rev.
Citation: Pharmacol. Rev. 64(3): 421-49
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 13:36  Last updated: 24th Oct 2013 at 16:16
Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation
Authors: I A Hauser, S Kruck, S Gauer, A T Nies, S Winter, J Bedke, H Geiger, H Hoefeld, J Kleemann, A Asbe-Vollkopf, J Engel, O Burk, M Schwab, E Schaeffeler
PubMed ID: 22453193
Date Published: 28th Mar 2012
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting
Journal: Clin. Pharmacol. Ther.
Citation: Clin. Pharmacol. Ther. 91(5): 905-16
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 13:01  Last updated: 24th Oct 2013 at 16:16
Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
Authors: Dechun Feng, Xiaoni Kong, Honglei Weng, Ogyi Park, Hua Wang, Steven Dooley, M Eric Gershwin, Bin Gao
PubMed ID: 22484119
Date Published: 3rd Apr 2012
Projects: Showcase LPS and Inflammation
Journal: Gastroenterology
Citation: Gastroenterology 143(1): 188-98.e7
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 09:09  Last updated: 24th Oct 2013 at 16:16
Authors: Uwe Freudenberg, Jens-Uwe Sommer, Kandice R. Levental, Petra B. Welzel, Andrea Zieris, Karolina Chwalek, Katja Schneider, Silvana Prokoph, Marina Prewitz, Ron Dockhorn, Carsten Werner
Date Published: 10th Apr 2012
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.3: Hepatocyte polarity, A3.5: The impact of cell polarity on metabolism detoxification and endoc..., B3: Intercellular communication through cell adhesion
Journal: Adv. Funct. Mater.
Citation: Adv. Funct. Mater. 22(7) : 1391
Scales: Not specified
Abstract (Expand)
Created: 29th Nov 2012 at 16:44  Last updated: 24th Oct 2013 at 16:16
The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity
Authors: Matthias Stein, Manohar Pilli, Sabine Bernauer, Bianca H Habermann, Marino Zerial, Rebecca C Wade
PubMed ID: 22523562
Date Published: 16th Apr 2012
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 7(4): e34870
Scales: Cell
Abstract (Expand)
Created: 19th Jul 2012 at 09:45  Last updated: 24th Oct 2013 at 16:16
Authors: C Kreutz, J S Gehring, D Lang, R Reski, J Timmer, S A Rensing
PubMed ID: 22513994
Date Published: 17th Apr 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Bioinformatics
Citation: Bioinformatics 28(12): 1641-2
Scales: Cell
Abstract (Expand)
Created: 8th Aug 2012 at 12:11  Last updated: 24th Oct 2013 at 16:16
Authors: Yijun Wu, Qi Li, Xinhui Zhou, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Müllenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Kouichi Matsuzaki, Youming Li, Steven Dooley, Honglei Weng
PubMed ID: 22539990
Date Published: 23rd Apr 2012
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., Show cases
Journal: PLoS ONE
Citation: PLoS ONE 7(4): e35684
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 09:13  Last updated: 24th Oct 2013 at 16:16
Modeling the impact of granular embedding media, and pulling versus pushing cells on growing cell clones
Authors: Dirk Drasdo, Stefan Hoehme
DOI: 10.1088/1367-2630/14/5/055025
Date Published: 1st May 2012
Projects: No Projects
Journal: New J. Phys.
Citation: New J. Phys. 14(5) : 055025
Scales: Not specified
Abstract (Expand)
Created: 10th Sep 2012 at 17:48  Last updated: 24th Oct 2013 at 16:16
Authors: Falk Rauchfuss, Sandro Lambeck, Ralf A Claus, Janina Ullmann, Thomas Schulz, Martina Weber, Katrin Katenkamp, Reinhard Guthke, Michael Bauer, Utz Settmacher
PubMed ID: 22561445
Date Published: 5th May 2012
Projects: C3: Zonation of metabolism and its regulation
Journal: Dig Liver Dis
Citation: Dig Liver Dis 44(8): 681-8
Scales: Not specified
Abstract (Expand)
Created: 30th Nov 2012 at 14:45  Last updated: 24th Oct 2013 at 16:16
Authors: Katrin Straßburger, Marcel Tiebe, Federico Pinna, Kai Breuhahn, Aurelio A Teleman
PubMed ID: 22609549
Date Published: 16th May 2012
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga...
Journal: Dev. Biol.
Citation: Dev. Biol. 367(2): 187-96
Scales: Cell
Abstract (Expand)
Created: 16th Jan 2013 at 09:03  Last updated: 24th Oct 2013 at 16:16
Authors: J. D. Stewart, R. Marchan, M. S. Lesjak, J. Lambert, R. Hergenroeder, J. K. Ellis, C.-H. Lau, H. C. Keun, G. Schmitz, J. Schiller, M. Eibisch, C. Hedberg, H. Waldmann, E. Lausch, B. Tanner, J. Sehouli, J. Sagemueller, H. Staude, E. Steiner, J. G. Hengstler
Date Published: 22nd May 2012
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Proceedings of the National Academy of Sciences
Citation: Proceedings of the National Academy of Sciences 109(21) : 8155
Scales: Not specified
Abstract:
Created: 29th Oct 2012 at 12:28  Last updated: 24th Oct 2013 at 16:16
Time-dependent intensity changes of free fatty acids detected by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry in the presence of 1,8-bis-(dimethylamino)naphthalene--a cautionary note
Authors: Mandy Eibisch, Rosmarie Süss, Jürgen Schiller
PubMed ID: 22638975
Date Published: 29th May 2012
Projects: No Projects
Journal: Rapid Commun. Mass Spectrom.
Citation: Rapid Commun. Mass Spectrom. 26(13): 1573-6
Scales: Not specified
Abstract:
Created: 4th Aug 2012 at 16:26  Last updated: 24th Oct 2013 at 16:16
Authors: Andreas Teufel, Diana Becker, Susanne N Weber, Steven Dooley, Katja Breitkopf-Heinlein, Thorsten Maass, Katrin Hochrath, Markus Krupp, Jens U Marquardt, Martin Kolb, Bernhard Korn, Christof Niehrs, Tim Zimmermann, Patricio Godoy, Peter R Galle, Frank Lammert
PubMed ID: 22669512
Date Published: 6th Jun 2012
Projects: B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Journal of molecular medicine (Berlin, Germany)
Citation: J. Mol. Med. 90(12): 1439-47
Scales: Not specified
Abstract (Expand)
Created: 31st Jul 2012 at 11:24  Last updated: 24th Oct 2013 at 16:16
Tissue proteomics by one-dimensional gel electrophoresis combined with label-free protein quantification
Authors: Andrej Vasilj, Marc Gentzel, Elke Ueberham, Rolf Gebhardt, Andrej Shevchenko
PubMed ID: 22671763
Date Published: 21st Jun 2012
Scales: Cell
Abstract (Expand)
Created: 20th Jul 2012 at 10:20  Last updated: 24th Oct 2013 at 16:16
Authors: Juliane Gebauer, Stefan Schuster, Luís F de Figueiredo, Christoph Kaleta
PubMed ID: 22776428
Date Published: 11th Jul 2012
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: The FEBS journal
Citation: FEBS J. 279(17): 3192-202
Scales: Cell
Abstract (Expand)
Created: 1st Aug 2012 at 11:45  Last updated: 24th Oct 2013 at 16:16
Authors: Endre T Somogyi, Jean-Marie Bouteiller, James A Glazier, Matthias König, J Kyle Medley, Maciej H Swat, Herbert M Sauro
PubMed ID: 26085503
Date Published: 19th Jun 2015
Projects: No Projects
Journal: Bioinformatics
Citation: Bioinformatics :
Scales: Not specified
Abstract (Expand)
Created: 1st Jul 2015 at 16:00
Authors: Bernhard Steiert, Andreas Raue, Jens Timmer, Clemens Kreutz
PubMed ID: 22815723
Date Published: 16th Jul 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: PLoS ONE
Citation: PLoS ONE 7(7): e40052
Scales: Cell
Abstract (Expand)
Created: 8th Aug 2012 at 11:44  Last updated: 24th Oct 2013 at 16:16
Authors: Kristan E van der Vos, Pernilla Eliasson, Tassula Proikas-Cezanne, Stephin J Vervoort, Ruben van Boxtel, Marrit Putker, Iris J van Zutphen, Mario Mauthe, Sebastian Zellmer, Cornelieke Pals, Liesbeth P Verhagen, Marian J A Groot Koerkamp, A Koen Braat, Tobias B Dansen, Frank C Holstege, Rolf Gebhardt, Boudewijn M Burgering, Paul J Coffer
PubMed ID: 22820375
Date Published: 22nd Jul 2012
Projects: A1: Cellular metabolism, A: Cellular level
Journal: Nat. Cell Biol.
Citation: Nat. Cell Biol. 14(8): 829-37
Scales: Cell
Abstract (Expand)
Created: 14th Aug 2012 at 14:52  Last updated: 24th Oct 2013 at 16:16
Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load
Authors: Jens Niklas, Anne Bonin, Stefanie Mangin, Joachim Bucher, Stephanie Kopacz, Madlen Matz-Soja, Carlo Thiel, Rolf Gebhardt, Ute Hofmann, Klaus Mauch
PubMed ID: 22831974
Date Published: 27th Jul 2012
Projects: A1: Cellular metabolism, A: Cellular level
Journal: BMB Rep
Citation: BMB Rep 45(7): 396-401
Scales: Not specified
Abstract (Expand)
Created: 14th Aug 2012 at 14:54  Last updated: 24th Oct 2013 at 16:16
Authors: Iwona Stelniec-Klotz, Stefan Legewie, Oleg Tchernitsa, Franziska Witzel, Bertram Klinger, Christine Sers, Hanspeter Herzel, Nils Blüthgen, Reinhold Schäfer
PubMed ID: 22864383
Date Published: 7th Aug 2012
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Mol. Syst. Biol.
Citation: Mol. Syst. Biol. 8: 601
Scales: Cell
Abstract (Expand)
Created: 3rd Sep 2012 at 11:20  Last updated: 24th Oct 2013 at 16:16
Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting
Authors: Claudia Fritsch, Alexander Herrmann, Michael Nothnagel, Karol Szafranski, Klaus Huse, Frank Schumann, Stefan Schreiber, Matthias Platzer, Michael Krawczak, Jochen Hampe, Mario Brosch
PubMed ID: 22879431
Date Published: 9th Aug 2012
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, G: Clinical translation
Journal: Genome Res.
Citation: Genome Res. 22(11): 2208-18
Scales: Cell
Abstract (Expand)
Created: 4th Oct 2012 at 19:40  Last updated: 24th Oct 2013 at 16:16
Authors: Daniel Kaschek, Jens Timmer
PubMed ID: 22892133
Date Published: 14th Aug 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: BMC Syst Biol
Citation: BMC Syst Biol 6: 99
Scales: Cell
Abstract (Expand)
Created: 29th Oct 2012 at 10:50  Last updated: 24th Oct 2013 at 16:16
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus
Authors: Oliver von Kampen, Stephan Buch, Michael Nothnagel, Lorena Azocar, Hector Molina, Mario Brosch, Wiebke Erhart, Witigo von Schönfels, Jan Egberts, Marcus Seeger, Alexander Arlt, Tobias Balschun, Andre Franke, Markus M Lerch, Julia Mayerle, Wolfgang Kratzer, Bernhard O Boehm, Klaus Huse, Bodo Schniewind, Katharina Tiemann, Zhao-Yyan Jiang, Tian-Quan Han, Balraj Mittal, Anshika Srivastava, Mogens Fenger, Torben Jørgensen, Ramin Schirin-Sokhan, Anke Tönjes, Henning Wittenburg, Michael Stumvoll, Holger Kalthoff, Frank Lammert, Jürgen Tepel, Klaus Puschel, Thomas Becker, Stefan Schreiber, Matthias Platzer, Henry Völzke, Michael Krawczak, Juan Francisco Miquel, Clemens Schafmayer, Jochen Hampe
PubMed ID: 22898925
Date Published: 18th Aug 2012
Scales: Organism
Abstract (Expand)
Created: 4th Oct 2012 at 19:37  Last updated: 24th Oct 2013 at 16:16
Multi-Target Regulation by Small RNAs Synchronizes Gene Expression Thresholds and May Enhance Ultrasensitive Behavior
Authors: Jörn Matthias Schmiedel, Ilka Maria Axmann, Stefan Legewie
PubMed ID: 22927924
Date Published: 21st Aug 2012
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: PLoS ONE
Citation: PLoS ONE 7(8): e42296
Scales: Cell
Abstract (Expand)
Created: 3rd Sep 2012 at 11:02  Last updated: 24th Oct 2013 at 16:16
Authors: Indumathi Chennamsetty, Karam M Kostner, Thierry Claudel, Manjula Vinod, Sasa Frank, Thomas S Weiss, Michael Trauner, Gerhard M Kostner
PubMed ID: 22930813
Date Published: 28th Aug 2012
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., CTU SOP Human Hepatocytes
Journal: J. Lipid Res.
Citation: J. Lipid Res. 53(11): 2405-12
Author: Andreas Hoppe
Date Published: 1st Sep 2012
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Metabolites
Citation: Metabolites 2(4) : 614
Scales: Not specified
Abstract (Expand)
Created: 23rd Oct 2012 at 12:30  Last updated: 24th Oct 2013 at 16:16
Authors: M Schelker, A Raue, J Timmer, C Kreutz
PubMed ID: 22962477
Date Published: 11th Sep 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Bioinformatics
Citation: Bioinformatics 28(18): i529-i534
Scales: Cell
Abstract (Expand)
Created: 29th Oct 2012 at 10:19  Last updated: 24th Oct 2013 at 16:15
Author: Anja Voss-Böhme
DOI: 10.1371/journal.pone.0042852
Date Published: 11th Sep 2012
Projects: A3.3: Hepatocyte polarity, B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., E2: Integration on the liver lobule scale: Image processing and mathemat...
Journal: PLoS ONE
Citation: PLoS ONE 7(9) : e42852
Scales: Cell
Abstract (Expand)
Created: 21st Sep 2012 at 14:45  Last updated: 24th Oct 2013 at 16:15
Authors: Anne T Nies, Katja Damme, Elke Schaeffeler, Matthias Schwab
PubMed ID: 22970772
Date Published: 13th Sep 2012
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Expert Opin Drug Metab Toxicol
Citation: Expert Opin Drug Metab Toxicol 8(12): 1565-77
Scales: Not specified
Abstract (Expand)
Created: 10th Jan 2013 at 10:39  Last updated: 24th Oct 2013 at 16:15
Authors: Christoph Thiele, Cyrus Papan, Dominik Hoelper, Kalina Kusserow, Anne Gaebler, Mario Schoene, Kira Piotrowitz, Daniel Lohmann, Johanna Spandl, Ana Stevanovic, Andrej Shevchenko, Lars Kuerschner
PubMed ID: 22999348
Date Published: 25th Sep 2012
Scales: Cell
Abstract (Expand)
Created: 26th Oct 2012 at 16:36  Last updated: 24th Oct 2013 at 16:15
Authors: Hamed Alborzinia, Hannah Schmidt-Glenewinkel, Iryna Ilkavets, Katja Breitkopf-Heinlein, Xinlai Cheng, Peter Hortschansky, Steven Dooley, Stefan Wölfl
PubMed ID: 23077176
Date Published: 19th Oct 2012
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: J. Cell. Sci.
Citation: J. Cell. Sci. 126(Pt 1): 117-27
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 09:20  Last updated: 24th Oct 2013 at 16:15
The Process-Interaction-Model: a common representation of rule-based and logical models allows studying signal transduction on different levels of detail
Authors: Katrin Kolczyk, Regina Samaga, Holger Conzelmann, Sebastian Mirschel, Carsten Conradi
PubMed ID: 23020215
Date Published: 28th Sep 2012
Projects: E1: Integration on the cellular level
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 13: 251
Authors: Nils Blüthgen, Stefan Legewie
PubMed ID: 23007845
Date Published: 25th Sep 2012
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Cell. Mol. Life Sci.
Citation: Cell. Mol. Life Sci. 70(13): 2259-69
Scales: Cell and Intercellular
Abstract (Expand)
Created: 20th Jan 2014 at 16:31
SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b
Authors: Jeong Kyu Kim, Ji Heon Noh, Kwang Hwa Jung, Jung Woo Eun, Hyun Jin Bae, Min Gyu Kim, Young Gyoon Chang, Qingyu Shen, Won Sang Park, Jung Young Lee, Jürgen Borlak, Suk Woo Nam
PubMed ID: 23079745
Date Published: 20th Oct 2012
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Hepatology
Citation: Hepatology 57(3): 1055-67
Scales: Cell
Abstract (Expand)
Created: 28th Jan 2013 at 13:50  Last updated: 24th Oct 2013 at 16:15
Authors: J. Starruss, F. Peruani, V. Jakovljevic, L. Sogaard-Andersen, A. Deutsch, M. Bar
Date Published: 25th Oct 2012
Projects: B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion
Journal: Interface Focus
Citation: Interface Focus 2(6) : 774
Scales: Cell, Intercellular and Liver lobule
Abstract:
Created: 12th Nov 2012 at 15:43  Last updated: 24th Oct 2013 at 16:15
Authors: Markus Krauss, Stephan Schaller, Steffen Borchers, Rolf Findeisen, Jörg Lippert, Lars Kuepfer
DOI: 10.1371/journal.pcbi.1002750
Date Published: 25th Oct 2012
Projects: E4: Vertical integration across biological scales, E: Model integration
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 8(10) : e1002750
Scales: Cell, Liver and Organism
Abstract (Expand)
Created: 29th Oct 2012 at 12:17  Last updated: 24th Oct 2013 at 16:15
Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models
Authors: Jens Niklas, Juan G Diaz Ochoa, Joachim Bucher, Klaus Mauch
Date Published: 14th Nov 2012
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Mol. Inf.
Citation: Mol. Inf. 32(1) : 14
Scales: Not specified
Abstract (Expand)
Created: 16th Jan 2013 at 11:43  Last updated: 24th Oct 2013 at 16:15
Authors: Matthias Schwab, Elke Schaeffeler
PubMed ID: 23194652
Date Published: 29th Nov 2012
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Genome Med
Citation: Genome Med 4(11): 93
Scales: Not specified
Abstract:
Created: 5th Dec 2012 at 09:51  Last updated: 24th Oct 2013 at 16:15
Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration
Authors: René Meyer, Lorenza A D'Alessandro, Sandip Kar, Bernhard Kramer, Bin She, Daniel Kaschek, Bettina Hahn, David Wrangborg, Johan Karlsson, Mats Kvarnström, Mats Jirstrand, Wolf-Dieter Lehmann, Jens Timmer, Thomas Höfer, Ursula Klingmüller
PubMed ID: 23226133
Date Published: 28th Nov 2012
Projects: No Projects
Journal: Front Physiol
Citation: Front Physiol 3: 451
Scales: Not specified
Abstract (Expand)
Created: 10th Jan 2013 at 14:27  Last updated: 24th Oct 2013 at 16:15
Authors: Bettina Hahn, Lorenza Alice D Alessandro, Sofia Depner, Katharina Waldow, Martin Erich Boehm, Julie Bachmann, Marcel Schilling, Ursula Klingmüller, Wolf Dieter Lehmann
PubMed ID: 23210697
Date Published: 6th Dec 2012
Projects: No Projects
Journal: J. Proteome Res.
Citation: J. Proteome Res. 12(2): 637-46
Scales: Not specified
Abstract (Expand)
Created: 10th Jan 2013 at 14:19  Last updated: 24th Oct 2013 at 16:15
Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment
Authors: Lars Wiechert, Julia Németh, Tobias Pusterla, Christine Bauer, Aurora De Ponti, Sandra Manthey, Silke Marhenke, Arndt Vogel, Ursula Klingmüller, Jochen Hess, Peter Angel
PubMed ID: 23241281
Date Published: 15th Dec 2012
Projects: No Projects
Journal: Cell Commun. Signal
Citation: Cell Commun. Signal 10(1): 40
Scales: Not specified
Abstract:
Created: 10th Jan 2013 at 14:31  Last updated: 24th Oct 2013 at 16:15
Selective Protection of Human Liver Tissue in TNF-Targeting of Cancers of the Liver by Transient Depletion of Adenosine Triphosphate
Authors: Timo Weiland, Kathrin Klein, Martina Zimmermann, Tobias Speicher, Sascha Venturelli, Alexander Berger, Heike Bantel, Alfred Königsrainer, Martin Schenk, Thomas S Weiss, Albrecht Wendel, Matthias Schwab, Michael Bitzer, Ulrich M Lauer
PubMed ID: 23272249
Date Published: 18th Dec 2012
Projects: A3.4: Linking signalling to metabolic functions, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: PLoS ONE
Citation: PLoS ONE 7(12): e52496
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2013 at 10:43  Last updated: 24th Oct 2013 at 16:15
Authors: Federico Pinna, Sven Sahle, Katharina Beuke, Michaela Bissinger, Selcan Tuncay, Lorenz A D'Alessandro, Ralph Gauges, Andreas Raue, Jens Timmer, Ursula Klingmüller, Peter Schirmacher, Ursula Kummer, Kai Breuhahn
PubMed ID: 23293603
Date Published: 31st Dec 2012
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces...
Journal: Front Physiol
Citation: Front Physiol 3: 466
Scales: Cell and Intercellular
Abstract (Expand)
Created: 16th Jan 2013 at 08:49  Last updated: 24th Oct 2013 at 16:15
Authors: Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, Irmgard Merfort
DOI: 10.1007/978-1-4614-4009-3_5
Date Published: 2013
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., Showcase LPS and Inflammation
Book: Systems Biology of Apoptosis
Citation: Systems Biology of Apoptosis : 101
Scales: Cell
Abstract (Expand)
Created: 7th Oct 2012 at 15:22  Last updated: 23rd Jul 2015 at 13:38
Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification
Authors: Markus Krauss, Rolf Burghaus, Jörg Lippert, Mikko Niemi, Pertti Neuvonen, Andreas Schuppert, Stefan Willmann, Lars Kuepfer, Linus Görlitz
Date Published: 2013
Projects: G: Clinical translation
Journal: In Silico Pharmacol
Citation: In Silico Pharmacol 1(1) : 6
Abstract (Expand)
Created: 16th Sep 2013 at 13:50  Last updated: 24th Oct 2013 at 16:15
Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
Authors: Uwe Benary, Bente Kofahl, Andreas Hecht, Jana Wolf
Date Published: 2013
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.2: Importance of Wnt- and Hedgehog factors for hepatic stellate cells...
Journal: Front. Physiol.
Citation: Front. Physiol. 4
Scales: Cell
Abstract (Expand)
Created: 27th Feb 2013 at 10:06  Last updated: 24th Oct 2013 at 16:15
Authors: J Lippert, M Brosch, O von Kampen, M Meyer, H.-U Siegmund, C Schafmayer, T Becker, B Laffert, L Goerlitz, S Schreiber, PJ Neuvonen, M Niemi, J Hampe, L Kuepfer
DOI: 10.1038/psp.2012.22
Date Published: 2013
Projects: G3: Clinical Translation to Pharmaceutical Drug Development, G: Clinical translation
Journal: CPT: pharmacomet. syst. pharmacol.
Citation: CPT: pharmacomet. syst. pharmacol. 2(1) : e21
Scales: Not specified
Abstract:
Created: 28th Jan 2013 at 09:55  Last updated: 24th Oct 2013 at 16:15
Authors: Christoph Meyer, Johanna Dzieran, Yan Liu, Felizitas Schindler, Stefan Munker, Alexandra Müller, Cédric Coulouarn, Steven Dooley
Date Published: 2013
Projects: A3.3: Hepatocyte polarity
Journal: Cell Commun Signal
Citation: Cell Commun Signal 11(1) : 6
Scales: Cell
Abstract:
Created: 23rd Jan 2013 at 17:57  Last updated: 24th Oct 2013 at 16:15
Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells
Authors: Qi Li, Xing Gu, Honglei Weng, Shahrouz Ghafoory, Yan Liu, Teng Feng, Johanna Dzieran, Li Li, Iryna Ilkavets, Marianna Kruithof-de Julio, Stefan Munker, Alexander Marx, Albrecht Piiper, Eduardo Augusto Alonso, Norbert Gretz, Chunfang Gao, Stefan Wölfl, Steven Dooley, Katja Breitkopf-Heinlein
PubMed ID: 23281849
Date Published: 4th Jan 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A3.3: Hepatocyte polarity, B2.1: Hepatic stellate cells as source and target for hepatocellular gro..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd...
Journal: Cancer Sci.
Citation: Cancer Sci. 104(3): 398-408
Scales: Cell
Abstract (Expand)
Created: 18th Jan 2013 at 10:41  Last updated: 24th Oct 2013 at 16:15
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Authors: Juan G Diaz Ochoa, Joachim Bucher, Alexandre R R Péry, José M Zaldivar Comenges, Jens Niklas, Klaus Mauch
PubMed ID: 23346056
Date Published: 22nd Jan 2013
Projects: No Projects
Journal: Front Pharmacol
Citation: Front Pharmacol 3: 204
Scales: Not specified
Abstract (Expand)
Created: 4th Feb 2013 at 11:46  Last updated: 24th Oct 2013 at 16:15
Authors: André Homeyer, Andrea Schenk, Janine Arlt, Uta Dahmen, Olaf Dirsch, Horst K. Hahn
DOI: 10.1016/j.cmpb.2015.05.009
Date Published: 1st Jun 2015
Projects: D4: Regeneration and Liver Size, Showcase Steatosis
Journal: Computer Methods and Programs in Biomedicine
Citation: Computer Methods and Programs in Biomedicine
Scales: Cell, Liver lobule and Liver
Abstract (Expand)
Created: 25th Jun 2015 at 09:02  Last updated: 29th Jun 2015 at 09:38
Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach
Authors: T Ricken, D Werner, H G Holzhütter, M König, U Dahmen, O Dirsch
PubMed ID: 25236798
Date Published: 19th Sep 2014
Projects: A1: Cellular metabolism, C: Liver lobule level, E: Model integration
Journal: Biomech Model Mechanobiol
Citation: Biomech Model Mechanobiol 14(3): 515-36
Scales: Cell and Liver lobule
Abstract (Expand)
Created: 30th Jun 2015 at 07:09
Differently Saturated Fatty Acids Can Be Differentiated by (31)P NMR Subsequent to Derivatization with 2-Chloro-4,4,5,5-tetramethyldioxaphospholane: A Cautionary Note
Authors: Mandy Eibisch, Thomas Riemer, Beate Fuchs, Jürgen Schiller
PubMed ID: 23414224
Date Published: 26th Feb 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: J. Agric. Food Chem.
Citation: J. Agric. Food Chem. 61(11): 2696-700
Scales: Not specified
Abstract (Expand)
Created: 6th Jan 2014 at 13:54
Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Authors: Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha, Julio Saez-Rodriguez
PubMed ID: 23525368
Date Published: 26th Mar 2013
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, E: Model integration, Virtual Liver
Journal: Mol Biosyst
Citation: Mol Biosyst 9(7): 1576-83
Scales: Cell, Liver and Organism
Abstract (Expand)
Created: 3rd Jun 2013 at 16:37  Last updated: 24th Oct 2013 at 16:14
Authors: Anne Gaebler, Robin Milan, Leon Straub, Dominik Hoelper, Lars Kuerschner, Christoph Thiele
PubMed ID: 23709689
Date Published: 23rd May 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: J. Lipid Res.
Citation: J. Lipid Res. 54(8): 2282-90
Scales: Not specified
Abstract (Expand)
Created: 6th Jan 2014 at 11:19
Authors: Regina Samaga, Steffen Klamt
PubMed ID: 23803171
Date Published: 26th Jun 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg...
Journal: Cell Commun. Signal
Citation: Cell Commun. Signal 11(1): 43
Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration
Authors: Rania Dayoub, Arndt Vogel, Jutta Schuett, Madeleine Lupke, Susannah M Spieker, Nadja Kettern, Eberhard Hildt, Michael Melter, Thomas S Weiss
PubMed ID: 23887691
Date Published: 23rd Jul 2013
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., CTU SOP Human Hepatocytes
Journal: Mol. Med.
Citation: Mol. Med. 19: 237-44
Authors: Marc Hovestädt, Ulrike Kuckelkorn, Agathe Niewienda, Christin Keller, Andrean Goede, Bernhard Ay, Stefan Günther, Katharina Janek, Rudolf Volkmer, Hermann-Georg Holzhütter
PubMed ID: 23893543
Date Published: 28th Jul 2013
Projects: No Projects
Journal: J. Pept. Sci.
Citation: J. Pept. Sci. 19(9): 588-97
Scales: Not specified
Abstract (Expand)
Created: 9th Sep 2013 at 15:19  Last updated: 24th Oct 2013 at 16:14
Authors: Sabrina Krautbauer, Josef Wanninger, Kristina Eisinger, Yvonne Hader, Michael Beck, Andrea Kopp, Andreas Schmid, Thomas S Weiss, Christoph Dorn, Christa Buechler
PubMed ID: 23906870
Date Published: 29th Jul 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.6: Transcription factor network and links to metabolism in NAFLD, CTU SOP Human Hepatocytes, Show cases
Journal: Exp. Mol. Pathol.
Citation: Exp. Mol. Pathol. 95(2): 199-205
Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse
Authors: Roman Liebe, Rabea A Hall, Robert W Williams, Steven Dooley, Frank Lammert
PubMed ID: 23943854
Date Published: 13th Aug 2013
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., Showcase LPS and Inflammation
Journal: Physiol. Genomics
Citation: Physiol. Genomics 45(20): 931-9
Scales: Not specified
Abstract (Expand)
Created: 6th Dec 2013 at 09:19
Authors: N. Rodriguez, A. Thomas, L. Watanabe, I. Y. Vazirabad, V. Kofia, H. F. Gomez, F. Mittag, J. Matthes, J. Rudolph, F. Wrzodek, E. Netz, A. Diamantikos, J. Eichner, R. Keller, C. Wrzodek, S. Frohlich, N. E. Lewis, C. J. Myers, N. Le Novere, B. O. Palsson, M. Hucka, A. Drager
PubMed ID: 26079347
Date Published: 17th Jun 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Bioinformatics
Citation: Bioinformatics :
Scales: Cell, Intercellular, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 22nd Jun 2015 at 17:56
Authors: Georg Damm, Elisa Pfeiffer, Britta Burkhardt, Jan Vermehren, Andreas K. Nüssler, Thomas S. Weiss
DOI: 10.1007/s12072-013-9475-7
Date Published: 1st Oct 2013
Projects: CTU SOP Hepatic stellate cells, human, CTU SOP Human Hepatocytes, CTU SOP Kupffer cells/macrophages, human, CTU SOP Liver sinusoidal endothelial cells, human
Journal: Hepatol Int
Citation: Hepatol Int 7(4) : 951
Scales: Cell
Abstract:
Created: 30th Jan 2014 at 16:52  Last updated: 30th Jan 2014 at 16:54
Authors: Shahrouz Ghafoory, Katja Breitkopf-Heinlein, Qi Li, Catharina Scholl, Steven Dooley, Stefan Wölfl
PubMed ID: 24147127
Date Published: 17th Oct 2013
Projects: C5: Structural changes and functional consequences of the liver lobular/..., Showcase HGF and Regeneration
Journal: PLoS ONE
Citation: PLoS ONE 8(10): e78262
Scales: Not specified
Abstract (Expand)
Created: 5th Feb 2014 at 12:26
Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease
Authors: Sabrina Krautbauer, Kristina Eisinger, Madeleine Lupke, Josef Wanninger, Petra Ruemmele, Yvonne Hader, Thomas S Weiss, Christa Buechler
PubMed ID: 24161595
Date Published: 22nd Oct 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Exp. Mol. Pathol.
Citation: Exp. Mol. Pathol. 95(3): 330-5
Authors: A Köhn-Luque, W de Back, Y Yamaguchi, K Yoshimura, M A Herrero, T Miura
DOI: 10.1088/1478-3975/10/6/066007
Date Published: 1st Dec 2013
Projects: B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/...
Journal: Phys. Biol.
Citation: Phys. Biol. 10(6) : 066007
Scales: Intercellular
Abstract (Expand)
Created: 24th Jan 2014 at 13:54  Last updated: 24th Jan 2014 at 13:57
Authors: Matthias Jeschke, Stephan Baumgärtner, Stefan Legewie
PubMed ID: 24339758
Date Published: 5th Dec 2013
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: PLoS Comput. Biol.
Citation: PLoS Comput. Biol. 9(12): e1003357
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 16:29
Authors: Osvaldo Chara, Elly M. Tanaka, Lutz Brusch
DOI: 10.1016/B978-0-12-391498-9.00011-5
Date Published: 2014
Projects: A3.3: Hepatocyte polarity, A3.5: The impact of cell polarity on metabolism detoxification and endoc..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., D4: Regeneration and Liver Size, Showcase LIAM (Liver Image Analysis Based Model)
Book: Mechanisms of Regeneration
Citation: Current Topics in Developmental Biology 108 : 283
Scales: Not specified
Abstract:
Created: 22nd Jan 2015 at 16:09  Last updated: 22nd Jan 2015 at 16:11
Authors: Olaf Wolkenhauer, Charles Auffray, Olivier Brass, Jean Clairambault, Andreas Deutsch, Dirk Drasdo, Francesco Gervasio, Luigi Preziosi, Philip Maini, Anna Marciniak-Czochra, Christina Kossow, Lars Kuepfer, Katja Rateitschak, Ignacio Ramis-Conde, Benjamin Ribba, Andreas Schuppert, Rod Smallwood, Georgios Stamatakos, Felix Winter, Helen Byrne
DOI: 10.1186/gm538
Date Published: 2014
Projects: No Projects
Journal: Genome Med
Citation: Genome Med 6(3) : 21
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:10  Last updated: 7th Nov 2014 at 15:10
A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis
Authors: Souhayla El Maadidi, Laura Faletti, Birgit Berg, Christin Wenzl, Katrin Wieland, Zhijian J Chen, Ulrich Maurer, Christoph Borner
PubMed ID: 24391214
Date Published: 3rd Jan 2014
Projects: No Projects
Journal: J. Immunol.
Citation: J. Immunol. 192(3): 1171-83
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:15
Authors: C Borner, D W Andrews
PubMed ID: 24413197
Date Published: 15th Jan 2014
Projects: No Projects
Journal: Cell Death Differ.
Citation: Cell Death Differ. 21(2): 187-91
Scales: Not specified
Abstract:
Created: 22nd Jan 2014 at 15:13
Authors: J. Starruss, W. d. Back, L. Brusch, A. Deutsch
DOI: 10.1093/bioinformatics/btt772
Date Published: 17th Jan 2014
Projects: A3.3: Hepatocyte polarity, A3: Crosslinking signalling metabolism and hepatocyte polarisation, B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., E2: Integration on the liver lobule scale: Image processing and mathemat..., E3: Horizontal integration on organ scale, E: Model integration, Showcase LIAM (Liver Image Analysis Based Model), Virtual Liver
Journal: Bioinformatics
Citation: Bioinformatics
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 20th Jan 2014 at 15:49  Last updated: 20th Jan 2014 at 16:16
Authors: Jose M Villaveces, Rafael C Jimenez, Bianca H Habermann
PubMed ID: 25075287
Date Published: 13th Feb 2014
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., A3: Crosslinking signalling metabolism and hepatocyte polarisation, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: F1000Res
Citation: F1000Res 3: 44
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:31
Authors: Jose M Villaveces, Rafael C Jimenez, Bianca H Habermann
PubMed ID: 24715980
Date Published: 13th Feb 2014
Projects: No Projects
Journal: F1000Res
Citation: F1000Res 3: 43
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:29
Authors: Madlen Matz-Soja, Susanne Aleithe, Eugenia Marbach, Jan Böttger, Katrin Arnold, Wolfgang Schmidt-Heck, Jürgen Kratzsch, Rolf Gebhardt
PubMed ID: 24548465
Date Published: 18th Feb 2014
Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation
Authors: Hai Li, Qiang Xia, Bo Zeng, Shu-Ting Li, Heng Liu, Qi Li, Jun Li, Shu-Yin Yang, Xiao-Jun Dong, Ting Gao, Stefan Munker, Yan Liu, Roman Liebe, Feng Xue, Qi-Gen Li, Xiao-Song Chen, Qiang Liu, Hui Zeng, Ji-Yao Wang, Qing Xie, Qin-Hua Meng, Jie-Fei Wang, Peter R Mertens, Frank Lammert, Manfred V Singer, Steven Dooley, Matthias P A Ebert, De-Kai Qiu, Tai-Ling Wang, Hong-Lei Weng
PubMed ID: 25646889
Date Published: 4th Feb 2015
Projects: C5: Structural changes and functional consequences of the liver lobular/...
Journal: J. Hepatol.
Citation: J. Hepatol. :
Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma
Authors: Teng Feng, Johanna Dzieran, Xing Gu, Silke Marhenke, Arndt Vogel, Keigo Machida, Thomas S Weiss, Petra Ruemmele, Otto Kollmar, Patrick Hoffmann, Friedrich Grässer, Heike Allgayer, Jasmin Fabian, Hong Lei Weng, Andreas Teufel, Thorsten Maass, Christoph Meyer, Ulrich Lehmann, Cheng Zhu, Peter R Mertens, Chun Fang Gao, Steven Dooley, Nadja M Meindl-Beinker
PubMed ID: 25602745
Date Published: 21st Jan 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd...
Journal: Clin. Sci.
Citation: Clin. Sci. 128(11): 761-74
Authors: Veronica Murahovschi, Olga Pivovarova, Iryna Ilkavets, Renata M Dmitrieva, Stephanie Döcke, Farnaz Keyhani-Nejad, Özlem Gögebakan, Martin Osterhoff, Margrit Kemper, Silke Hornemann, Mariya Markova, Nora Klöting, Martin Stockmann, Martin O Weickert, Valeria Lamounier-Zepter, Peter Neuhaus, Alexandra Konradi, Steven Dooley, Christian von Loeffelholz, Matthias Blüher, Andreas F H Pfeiffer, Natalia Rudovich
PubMed ID: 25281430
Date Published: 3rd Oct 2014
Projects: C5: Structural changes and functional consequences of the liver lobular/...
Journal: Diabetes
Citation: Diabetes 64(3): 856-66
Authors: Blanca Herrera, Steven Dooley, Katja Breitkopf-Heinlein
PubMed ID: 24670474
Date Published: 29th Mar 2014
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A3.3: Hepatocyte polarity, B2.1: Hepatic stellate cells as source and target for hepatocellular gro..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., Showcase HGF and Regeneration, Showcase LPS and Inflammation
Journal: Int J Mol Sci
Citation: Int J Mol Sci 15(4): 5199-220
Scales: Not specified
Abstract (Expand)
Created: 31st Mar 2014 at 11:18
Authors: Nadine Hohmann, Wei Weiwei, Uta Dahmen, Olaf Dirsch, Andreas Deutsch, Anja Voss-Böhme
DOI: 10.1371/journal.pone.0093207
Date Published: 1st Apr 2014
Scales: Intercellular, Liver lobule and Liver
Abstract (Expand)
Created: 24th Apr 2014 at 14:21  Last updated: 24th Apr 2014 at 14:26
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity
Authors: Gisela Campos, Wolfgang Schmidt-Heck, Ahmed Ghallab, Katharina Rochlitz, Larissa Pütter, Danilo B Medinas, Claudio Hetz, Agata Widera, Cristina Cadenas, Brigitte Begher-Tibbe, Raymond Reif, Georgia Günther, Agapios Sachinidis, Jan G Hengstler, Patricio Godoy
PubMed ID: 24748426
Date Published: 20th Apr 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C6: Organization and function of the sinusoidal system and the liver lob..., Showcase HGF and Regeneration
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. 88(6): 1267-80
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2015 at 13:25
Authors: Ulrike Wittig, Renate Kania, Meik Bittkowski, Elina Wetsch, Lei Shi, Lenneke Jong, Martin Golebiewski, Maja Rey, Andreas Weidemann, Isabel Rojas, Wolfgang Müller
DOI: 10.1016/j.pisc.2014.02.004
Date Published: 1st May 2014
Projects: F3: Kinetic data handling
Journal: Perspectives in Science
Citation: Perspectives in Science 1(1-6) : 33
Scales: Not specified
Abstract (Expand)
Created: 3rd Feb 2015 at 10:55  Last updated: 3rd Feb 2015 at 11:03
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
Authors: Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer
DOI: 10.1002/hep.27136
Date Published: 1st May 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.4: Linking signalling to metabolic functions
Journal: Hepatology
Citation: Hepatology : n/a
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:12  Last updated: 7th Nov 2014 at 15:12
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
Authors: Seddik Hammad, Stefan Hoehme, Adrian Friebel, Iris von Recklinghausen, Amnah Othman, Brigitte Begher-Tibbe, Raymond Reif, Patricio Godoy, Tim Johann, Amruta Vartak, Klaus Golka, Petru O. Bucur, Eric Vibert, Rosemarie Marchan, Bruno Christ, Steven Dooley, Christoph Meyer, Iryna Ilkavets, Uta Dahmen, Olaf Dirsch, Jan Böttger, Rolf Gebhardt, Dirk Drasdo, Jan G. Hengstler
DOI: 10.1007/s00204-014-1243-5
Date Published: 1st May 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., CTU Confocal microscopy, CTU Image Processing
Journal: Arch Toxicol
Citation: Arch Toxicol 88(5) : 1161
Scales: Liver lobule and Liver
Abstract:
Created: 7th Nov 2014 at 15:11  Last updated: 7th Nov 2014 at 15:11
Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6
Authors: Michael H Court, Fawziah E Almutairi, David J Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M Zanger, Joanne Bourgea, Christopher J Patten, Awewura Kwara
PubMed ID: 24820076
Date Published: 12th May 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G: Clinical translation
Journal: Antimicrob. Agents Chemother.
Citation: Antimicrob. Agents Chemother. 58(7): 4145-52
Scales: Not specified
Abstract (Expand)
Created: 8th Dec 2014 at 09:49
A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models
Authors: A. Ryll, J. Bucher, A. Bonin, S. Bongard, E. Gonçalves, J. Saez-Rodriguez, J. Niklas, S. Klamt
DOI: 10.1016/j.biosystems.2014.07.002
Date Published: 1st Jul 2014
Projects: A1: Cellular metabolism, A2.5: Integration of insulin and Wnt signalling in hepatocytes, A2: Integration of Signalling Pathways in Hepatocellular Response, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, Showcase Steatosis, Virtual Liver
Journal: Biosystems
Citation: Biosystems
Scales: Cell
Abstract (Expand)
Created: 6th Aug 2014 at 07:36  Last updated: 6th Aug 2014 at 07:50
Authors: Maria Thomas, Jessica K Rieger, Benjamin A Kandel, Kathrin Klein, Ulrich M Zanger
PubMed ID: 25012546
Date Published: 1st Jul 2014
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level
Journal: Cell. Physiol. Biochem.
Citation: Cell. Physiol. Biochem. 33(6): 2003-2013
Scales: Not specified
Abstract (Expand)
Created: 14th Jul 2014 at 13:17
Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells
Authors: Berit Genz, Maria Thomas, Brigitte M Pützer, Marcin Siatkowski, Georg Fuellen, Brigitte Vollmar, Kerstin Abshagen
PubMed ID: 24995995
Date Published: 6th Jul 2014
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells
Journal: Exp. Cell Res.
Citation: Exp. Cell Res. :
Authors: Rolf Gebhardt, Madlen Matz-Soja
PubMed ID: 25024605
Date Published: 16th Jul 2014
Projects: C3: Zonation of metabolism and its regulation, Virtual Liver
Journal: World J. Gastroenterol.
Citation: World J. Gastroenterol. 20(26): 8491-504
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 26th Jan 2015 at 09:50
Authors: L Kuepfer, R Kerb, A M Henney
DOI: 10.1038/psp.2014.25
Date Published: 30th Jul 2014
Projects: G: Clinical translation
Journal: CPT: pharmacomet. syst. pharmacol.
Citation: CPT: pharmacomet. syst. pharmacol. 3(7) : e127
Scales: Organism
Abstract:
Created: 13th Aug 2014 at 19:07  Last updated: 13th Aug 2014 at 19:12
morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring
Authors: Ines Wagner, Michael Volkmer, Malvika Sharan, Jose M Villaveces, Felix Oswald, Vineeth Surendranath, Bianca H Habermann
PubMed ID: 25096057
Date Published: 6th Aug 2014
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., A3: Crosslinking signalling metabolism and hepatocyte polarisation, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 15(1): 263
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:33
Authors: Christian Tönsing, Jens Timmer, Clemens Kreutz
PubMed ID: 25215847
Date Published: 11th Aug 2014
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Phys Rev E Stat Nonlin Soft Matter Phys
Citation: Phys Rev E Stat Nonlin Soft Matter Phys 90(2): 023303
Foxf1 SiRNA Delivery to Hepatic Stellate Cells by DBTC Lipoplex Formulations Ameliorates Fibrosis in Livers of Bile Duct Ligated Mice
Authors: Kerstin Abshagen, Malte Brensel, Berit Genz, Kira Roth, Maria Thomas, Volker Fehring, Ute Schaeper, Brigitte Vollmar
PubMed ID: 25619889
Date Published: 11th Aug 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Curr Gene Ther
Citation: Curr Gene Ther :
On Calculation of the Electrostatic Potential of a Phosphatidylinositol Phosphate-Containing Phosphatidylcholine Lipid Membrane Accounting for Membrane Dynamics
Authors: Jonathan C. Fuller, Michael Martinez, Rebecca C. Wade
DOI: 10.1371/journal.pone.0104778
Date Published: 20th Aug 2014
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 9(8) : e104778
Scales: Cell
Abstract (Expand)
Created: 20th Aug 2014 at 19:55  Last updated: 20th Aug 2014 at 19:57
The many faces of Hedgehog signalling in the liver: Recent progress reveals striking cellular diversity and the importance of microenvironments
Authors: Madlen Matz-Soja, Rolf Gebhardt
PubMed ID: 25152210
Date Published: 26th Aug 2014
Scales: Not specified
Abstract:
Created: 1st Dec 2014 at 15:54
Isolation and hepatocyte differentiation of mesenchymal stem cells from porcine bone marrow--"surgical waste" as a novel MSC source
Authors: S Brückner, H-M Tautenhahn, S Winkler, P Stock, S Jonas, M Dollinger, B Christ
PubMed ID: 23769107
Date Published: 19th Jun 2013
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase Steatosis
Journal: Transplant. Proc.
Citation: Transplant. Proc. 45(5): 2056-8
Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms
Authors: Andreas Bitter, Petra Rümmele, Kathrin Klein, Benjamin A Kandel, Jessica K Rieger, Andreas K Nüssler, Ulrich M Zanger, Michael Trauner, Matthias Schwab, Oliver Burk
PubMed ID: 25182422
Date Published: 3rd Sep 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G3: Clinical Translation to Pharmaceutical Drug Development, Showcase Steatosis
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. :
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 5th Dec 2014 at 12:44
Author: Adriano Henney
DOI: 10.4155/FMC.14.127
Date Published: 1st Oct 2014
Projects: No Projects
Journal: Future Medicinal Chemistry
Citation: Future Medicinal Chemistry 6(16) : 1735
Scales: Not specified
Abstract:
Created: 28th Nov 2014 at 17:48
Authors: Dirk Drasdo, Stefan Hoehme, Jan G. Hengstler
DOI: 10.1016/j.jhep.2014.06.013
Date Published: 1st Oct 2014
Projects: C: Liver lobule level
Journal: Journal of Hepatology
Citation: Journal of Hepatology 61(4) : 951
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:09  Last updated: 7th Nov 2014 at 15:09
Authors: Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen, Anja Schroeter
PubMed ID: 25248454
Date Published: 25th Sep 2014
Projects: No Projects
Journal: Mol Biosyst
Citation: Mol Biosyst 10(12): 3066-74
Scales: Not specified
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Created: 3rd Dec 2014 at 20:29
Authors: Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter, Stefan Schuster
PubMed ID: 25270362
Date Published: 2nd Oct 2014
Projects: No Projects
Journal: Mol Biosyst
Citation: Mol Biosyst 10(12): 3044-65
Scales: Not specified
Abstract (Expand)
Created: 3rd Dec 2014 at 20:25
Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma
Authors: Stefan Welte, Toni Urbanik, Christin Elßner, Nicole Kautz, Bruno Christian Koehler, Nina Waldburger, Justo Lorenzo Bermejo, Federico Pinna, Karl-Heinz Weiss, Peter Schemmer, Dirk Jaeger, Thomas Longerich, Kai Breuhahn, Henning Schulze-Bergkamen
DOI: 10.1371/journal.pone.0110591
Date Published: 16th Oct 2014
Projects: A2.1: Multi-level regulation of signalling pathways important for primin...
Journal: PLoS ONE
Citation: PLoS ONE 9(10) : e110591
Scales: Cell
Abstract:
Created: 20th Jan 2015 at 13:44  Last updated: 20th Jan 2015 at 13:46
Authors: Elisa Pfeiffer, Victoria Kegel, Katrin Zeilinger, Jan G Hengstler, Andreas K Nüssler, Daniel Seehofer, Georg Damm
PubMed ID: 25394621
Date Published: 15th Nov 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., CTU Liver bank
Journal: Exp. Biol. Med. (Maywood)
Citation: Exp. Biol. Med. (Maywood) :
Scales: Cell and Intercellular
Abstract (Expand)
Created: 5th Jan 2015 at 13:19
Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here
Authors: A Emami-Riedmaier, E Schaeffeler, A T Nies, K Mörike, M Schwab
PubMed ID: 25418285
Date Published: 25th Nov 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: J. Intern. Med.
Citation: J. Intern. Med. 277(2): 235-47
Scales: Not specified
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Created: 7th Apr 2015 at 14:50
Authors: C Priesnitz, S Sperber, R Garg, M Orsini, F Noor
PubMed ID: 25424145
Date Published: 26th Nov 2014
Projects: A1: Cellular metabolism, C3: Zonation of metabolism and its regulation
Journal: Cytotechnology
Citation: Cytotechnology :
Authors: J. C. Fuller, M. Martinez, S. Henrich, A. Stank, S. Richter, R. C. Wade
DOI: 10.1093/bioinformatics/btu784
Date Published: 29th Nov 2014
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., F3: Kinetic data handling
Journal: Bioinformatics
Citation: Bioinformatics
Scales: Cell
Abstract (Expand)
Created: 6th Dec 2014 at 18:03  Last updated: 6th Dec 2014 at 18:07
Authors: Alexander Dörr, Roland Keller, Andreas Zell, Andreas Dräger
DOI: 10.3390/computation2040246
Date Published: 1st Dec 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Computation
Citation: Computation 2(4) : 246
Scales: Cell and Intercellular
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Created: 14th Jan 2015 at 15:05  Last updated: 10th Jun 2015 at 18:36
Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression
Authors: Andreas Bitter, Andreas K Nüssler, Wolfgang E Thasler, Kathrin Klein, Ulrich M Zanger, Matthias Schwab, Oliver Burk
PubMed ID: 25634759
Date Published: 30th Jan 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, Showcase Steatosis
Journal: Cell. Physiol. Biochem.
Citation: Cell. Physiol. Biochem. 35(2): 803-15
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:59
Zonation of hepatic fatty acid metabolism - The diversity of its regulation and the benefit of modeling
Authors: J Schleicher, C Tokarski, E Marbach, M Matz-Soja, S Zellmer, R Gebhardt, S Schuster
PubMed ID: 25677822
Date Published: 14th Feb 2015
Projects: C3: Zonation of metabolism and its regulation
Journal: Biochim. Biophys. Acta
Citation: Biochim. Biophys. Acta :
Scales: Intercellular and Liver lobule
Abstract (Expand)
Created: 26th Feb 2015 at 09:40
Authors: David Zakim, Matthias Schwab
PubMed ID: 25479798
Date Published: 2nd Dec 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Trends Pharmacol. Sci.
Citation: Trends Pharmacol. Sci. 36(2): 68-71
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:54
Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes
Authors: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort
DOI: 10.1371/journal.pone.0115603
Date Published: 31st Dec 2014
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 9(12) : e115603
Scales: Cell
Abstract (Expand)
Created: 23rd Jan 2015 at 09:58  Last updated: 23rd Jan 2015 at 10:00
Authors: L.A. D'Alessandro, S. Hoehme, A. Henney, D. Drasdo, U. Klingmüller