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8 items tagged with 'kinetic model'.
Assays (1)
ID: 72
Biological problem addressed: Metabolic network
Investigation: Investigation: Glucose metabolism in the liver
Contributor: Matthias König
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions
Organisms: Not Specified
SOPs: No SOPs
Data files: No Data files
Publications (5)
Authors: Andreas Dräger, Daniel C Zielinski, Roland Keller, Matthias Rall, Johannes Eichner, Bernhard O Palsson, Andreas Zell
DOI: 10.1186/s12918-015-0212-9
Date Published: 1st Dec 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 9(1) : 389
Scales: Cell and Intercellular
Abstract (Expand)
Created: 16th Nov 2015 at 15:27 Last updated: 16th Nov 2015 at 15:29
Authors: Finja Büchel, Nicolas Rodriguez, Neil Swainston, Clemens Wrzodek, Tobias Czauderna, Roland Keller, Florian Mittag, Michael Schubert, Mihai Glont, Martin Golebiewski, Martijn van Iersel, Sarah Keating, Matthias Rall, Michael Wybrow, Henning Hermjakob, Michael Hucka, Douglas B Kell, Wolfgang Müller, Pedro Mendes, Andreas Zell, Claudine Chaouiya, Julio Saez-Rodriguez, Falk Schreiber, Camille Laibe, Andreas Dräger, Nicolas Le Novère
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 7(1) : 116
Scales: Cell and Intercellular
Abstract (Expand)
Created: 4th Nov 2013 at 16:48 Last updated: 4th Nov 2013 at 16:54
Authors: Andreas Dräger, Hannes Planatscher
DOI: 10.1007/978-1-4419-9863-7_1174
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Book: Encyclopedia of Systems Biology
Citation: Encyclopedia of Systems Biology : 1627
Scales: Cell
Abstract (Expand)
Created: 15th Aug 2013 at 23:37 Last updated: 23rd Jul 2015 at 13:38
Authors: Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, Irmgard Merfort
DOI: 10.1007/978-1-4614-4009-3_5
Date Published: 2013
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., Showcase LPS and Inflammation
Book: Systems Biology of Apoptosis
Citation: Systems Biology of Apoptosis : 101
Authors: M. Koenig, H.-G. Holzhuetter
Date Published: 12th Sep 2012
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1: Cellular metabolism, A3.4: Linking signalling to metabolic functions
Journal: Journal of Biological Chemistry
Citation: Journal of Biological Chemistry 287(44) : 36978
Abstract (Expand)
Created: 4th Oct 2012 at 18:18 Last updated: 24th Oct 2013 at 16:15
Presentations (2)
Uploader: Matthias König
Contributor: Hermann-Georg Holzhütter, Matthias König
Other contributors: Not specified
Version: 1
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., C1: The role of blood flow in liver lobule function and morphology, C2: Organization of the sinusoidal system and the liver lobule - referen..., C3: Zonation of metabolism and its regulation
Scales: Cell and Liver lobule
Overview preliminary results and first version of multi-scale model of human hepatic galactose metabolism.
First simulations of normal state and galactosemias.
See also:
Galactose investigation
http://seek.virtuelle-leber.de/investigations/88
Galactose study
http://seek.virtuelle-leber.de/studies/50
Galactose modelling assay
http://seek.virtuelle-leber.de/assays/71
Created: 3rd Nov 2013 at 15:03 Last updated: 8th Nov 2013 at 11:10
View
Download Uploader: Matthias König
Contributor: Hermann-Georg Holzhütter, Matthias König, Nikolaus Berndt
Other contributors: Not specified
Version: 1
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1: Cellular metabolism
Motivation
The central carbon metabolism of the liver enables the remarkable homeostasis of numerous plasma metabolites under a wide variety of nutritional regimes and physiological states. Examples are the synthesis of glucose by gluconeogenesis and synthesis of ketone-body from fatty acids under fasting conditions or the postprandial storage of glucose and lipids in terms of glycogen and triglycerides.
Results
In order to better understand the regulatory mechanism accounting for the switch
...
Created: 9th Jul 2012 at 20:15 Last updated: 9th Jul 2012 at 20:20
