Studies
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ID: 24
Investigation: Transplantation of stem cell-derived hepatocytes
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Contributor: Bruno Christ
Assays: No Assays
Scales: Liver
Mesenchymal stem cells are extracted from the tissue by collagenase digestion and enriched by their capacity to grow on plastic surfaces. Enriched cells display distinct mesenchymal surface markers and are capable of multiple lineage differentiation. In the presence of specific growth conditions, the cells adopt functional features of differentiated hepatocytes. After orthotopic transplantation, differentiated human stem cells engraft in the host liver parenchyma of immunocompromized mice. This
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Created: 24th Oct 2012 at 10:33
