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ID: 66
Investigation: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepatocytes: Impact on cell polarity and presence of transporters
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Contributor: Konstantina Diamantara
Assays: In vivo LNP injections
Scales: Cell, Intercellular and Liver
Created: 28th Feb 2014 at 12:38 Last updated: 11th Jan 2016 at 15:18
ID: 65
Investigation: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepatocytes: Impact on cell polarity and presence of transporters
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Contributor: Konstantina Diamantara
Assays: In vitro knock down of Rab5
Scales: Not specified
Created: 28th Feb 2014 at 11:08 Last updated: 11th Jan 2016 at 15:18
ID: 56
Investigation: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepatocytes: Impact on cell polarity and presence of transporters
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Contributor: Marino Zerial
Assays: EM analysis of LNP-gold-labelled-siRNAs trafficking in vivo, in vivo fluorescence analysis of LNP-siRNA-Alexa647
Scales: Intercellular and Liver lobule
Created: 6th Dec 2013 at 11:59
ID: 51
Investigation: Investigation: Glucose metabolism in the liver
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions
Contributor: Matthias König
Assays: Kinetic modelling of hepatic glucose metabolism
Scales: Liver
Created: 3rd Nov 2013 at 16:40
ID: 50
Investigation: Investigation: Multi-scale model galactose metabolism in the human liver
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., C1: The role of blood flow in liver lobule function and morphology, C2: Organization of the sinusoidal system and the liver lobule - referen..., C3: Zonation of metabolism and its regulation
Contributor: Matthias König
Assays: From Hepatocytes to Whole Liver Function: A Multi-Scale Model of Human ...
Scales: Cell, Liver lobule and Liver
Created: 3rd Nov 2013 at 15:12 Last updated: 3rd Nov 2013 at 15:55
ID: 7
Investigation: Integration of intracellular ODE models
Projects: E1: Integration on the cellular level
Contributor: Katrin Kolczyk
Assays: No Assays
Scales: Cell
Created: 2nd Mar 2011 at 10:39 Last updated: 19th Nov 2012 at 14:12
ID: 24
Investigation: Transplantation of stem cell-derived hepatocytes
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Contributor: Bruno Christ
Assays: No Assays
Scales: Liver
Mesenchymal stem cells are extracted from the tissue by collagenase digestion and enriched by their capacity to grow on plastic surfaces. Enriched cells display distinct mesenchymal surface markers and are capable of multiple lineage differentiation. In the presence of specific growth conditions, the cells adopt functional features of differentiated hepatocytes. After orthotopic transplantation, differentiated human stem cells engraft in the host liver parenchyma of immunocompromized mice. This
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Created: 24th Oct 2012 at 10:33
ID: 9
Investigation: Exchanging culture medium
Projects: HepatoSys
Contributor: Data From HepatoSys
Assays: Response of hepatocytes to rapid change in the medium composition (gene ..., Response of hepatocytes to rapid change in the medium composition (gene ...
Scales: Not specified
Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse
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Created: 1st Aug 2011 at 13:50 Last updated: 1st Aug 2011 at 13:56
