Publications

 

Wordprocessing The evolution of standards and data management practices in systems biology


Authors: N. J. Stanford, K. Wolstencroft, M. Golebiewski, R. Kania, N. Juty, C. Tomlinson, S. Owen, S. Butcher, H. Hermjakob, N. Le Novere, W. Mueller, J. Snoep, C. Goble

PubMed ID: 26700851

Date Published: 25th Dec 2015

Projects: F1: The data management system, Virtual Liver

Journal: Mol Syst Biol

Citation: Mol Syst Biol. 2015 Dec 23;11(12):851. doi: 10.15252/msb.20156053.

Scales: Not specified

Abstract:

Not specified

Created: 8th Jan 2016 at 09:38


 

Wordprocessing The Therapeutic Promise of Mesenchymal Stem Cells for Liver Restoration


Authors: B. Christ, S. Bruckner, S. Winkler

PubMed ID: 26476857

Date Published: 22nd Oct 2015

Projects: C6: Organization and function of the sinusoidal system and the liver lob...

Journal: Trends Mol Med

Citation: Trends Mol Med. 2015 Nov;21(11):673-86. doi: 10.1016/j.molmed.2015.09.004. Epub 2015 Oct 22.

Scales: Liver

Abstract (Expand)

Hepatocyte transplantation aims to provide a functional substitution of liver tissue lost due to trauma or toxins. Chronic liver diseases are associated with inflammation, deterioration of tissue ...

Created: 11th Nov 2015 at 11:21


 

Wordprocessing The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates proliferative and pro-inflammatory genes


Authors: M. Thomas, C. Bayha, K. Klein, S. Muller, T. S. Weiss, M. Schwab, U. M. Zanger

PubMed ID: 26122096

Date Published: 30th Jun 2015

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: BMC Cancer

Citation: BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x.

Scales: Not specified

Abstract (Expand)

BACKGROUND: The peroxisome proliferator-activated receptor alpha (PPARalpha) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARalpha-tr was suggested to ...

Created: 17th Sep 2015 at 10:19


 

Wordprocessing Tools for visualization and analysis of molecular networks, pathways, and -omics data


Authors: J. M. Villaveces, P. Koti, B. H. Habermann

PubMed ID: 26082651

Date Published: 4th Jun 2015

Scales: Not specified

Abstract (Expand)

Biological pathways have become the standard way to represent the coordinated reactions and actions of a series of molecules in a cell. A series of interconnected pathways is referred to as a biological ...

Created: 18th Dec 2015 at 12:57


 

Wordprocessing Ten Simple Rules for Organizing an Unconference


Authors: Aidan Budd, Holger Dinkel, Manuel Corpas, Jonathan C. Fuller, Laura Rubinat, Damien P. Devos, Pierre H. Khoueiry, Konrad U. Förstner, Fotis Georgatos, Francis Rowland, Malvika Sharan, Janos X. Binder, Tom Grace, Karyn Traphagen, Adam Gristwood, Natasha T. Wood

DOI: 10.1371/journal.pcbi.1003905

Date Published: 29th Jan 2015

Projects: No Projects

Journal: PLoS Comput Biol

Citation: PLoS Comput Biol 11(1) : e1003905

Scales: Not specified

Abstract:

Not specified

Created: 2nd Feb 2015 at 14:43   Last updated: 2nd Feb 2015 at 14:47


 

Wordprocessing The virtual liver: state of the art and future perspectives


Authors: Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G. Hengstler

DOI: 10.1007/s00204-014-1384-6

Date Published: 21st Oct 2014

Projects: No Projects

Journal: Arch Toxicol

Citation: Arch Toxicol

Scales: Not specified

Abstract:

Not specified

Created: 7th Nov 2014 at 15:06   Last updated: 7th Nov 2014 at 15:06


 

Wordprocessing The Virtual Liver Network: systems understanding from bench to bedside


Author: Adriano Henney

DOI: 10.4155/FMC.14.127

Date Published: 1st Oct 2014

Projects: No Projects

Journal: Future Medicinal Chemistry

Citation: Future Medicinal Chemistry 6(16) : 1735

Scales: Not specified

Abstract:

Not specified

Created: 28th Nov 2014 at 17:48


 

Wordprocessing Treatment of NASH with human mesenchymal stem cells in the immunodeficient mouse


Authors: Sandra Winkler, Bruno Christ

PubMed ID: 25173373

Date Published: 1st Sep 2014

Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis

Journal: Methods Mol. Biol.

Citation: Methods Mol. Biol. 1213: 51-6

Scales: Cell and Liver

Abstract (Expand)

Nonalcoholic steatohepatitis (NASH) as a severe form of nonalcoholic liver diseases (NAFLD) is one of the prominent liver diseases worldwide. Under favoring conditions it may progress into liver cirrhosis ...

Created: 15th Jan 2015 at 10:47


 

Wordprocessing The many faces of Hedgehog signalling in the liver: Recent progress reveals striking cellular diversity and the importance of microenvironments


Authors: Madlen Matz-Soja, Rolf Gebhardt

PubMed ID: 25152210

Date Published: 26th Aug 2014

Projects: A: Cellular level

Journal: J. Hepatol.

Citation: J. Hepatol. :

Scales: Not specified

Abstract:

Not specified

Created: 1st Dec 2014 at 15:54


 

Wordprocessing Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes


Authors: Maria Thomas, Jessica K Rieger, Benjamin A Kandel, Kathrin Klein, Ulrich M Zanger

PubMed ID: 25012546

Date Published: 1st Jul 2014

Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level

Journal: Cell. Physiol. Biochem.

Citation: Cell. Physiol. Biochem. 33(6): 2003-2013

Scales: Not specified

Abstract (Expand)

Background: RNA interference (RNAi) has tremendous potential for investigating gene function and for developing new therapies. Primary human hepatocytes (PHH) are the "gold standard" for ...

Created: 14th Jul 2014 at 13:17


 

Wordprocessing The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity


Authors: Gisela Campos, Wolfgang Schmidt-Heck, Ahmed Ghallab, Katharina Rochlitz, Larissa Pütter, Danilo B Medinas, Claudio Hetz, Agata Widera, Cristina Cadenas, Brigitte Begher-Tibbe, Raymond Reif, Georgia Günther, Agapios Sachinidis, Jan G Hengstler, Patricio Godoy

PubMed ID: 24748426

Date Published: 20th Apr 2014

Scales: Not specified

Abstract (Expand)

Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations, including modifications of proteins leading to endoplasmic reticulum stress (ER-stress). This ...

Created: 20th Jan 2015 at 13:25


 

Wordprocessing Toward predictive models for drug-induced liver injury in humans: are we there yet


Authors: Minjun Chen, Halil Bisgin, Lillian Tong, Huixiao Hong, Hong Fang, Jürgen Borlak, Weida Tong

PubMed ID: 24521015

Date Published: 14th Feb 2014

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Biomark Med

Citation: Biomark Med 8(2): 201-13

Scales: Liver

Abstract (Expand)

Drug-induced liver injury (DILI) is a frequent cause for the termination of drug development programs and a leading reason of drug withdrawal from the marketplace. Unfortunately, the current preclinical ...

Created: 28th Jun 2014 at 16:31


 

Wordprocessing The apoptotic pore on mitochondria: are we breaking through or still stuck


Authors: C Borner, D W Andrews

PubMed ID: 24413197

Date Published: 15th Jan 2014

Projects: No Projects

Journal: Cell Death Differ.

Citation: Cell Death Differ. 21(2): 187-91

Scales: Not specified

Abstract:

Not specified

Created: 22nd Jan 2014 at 15:13


 

Wordprocessing TFpredict and SABINE: Sequence-Based Prediction of Structural and Functional Characteristics of Transcription Factors


Authors: Johannes Eichner, Florian Topf, Andreas Dräger, Clemens Wrzodek, Dierk Wanke, Andreas Zell

DOI: 10.1371/journal.pone.0082238

Date Published: 12th Dec 2013

Scales: Cell and Intercellular

Abstract (Expand)

One of the key mechanisms of transcriptional control are the specific connections between transcription factors (TF) and cis-regulatory elements in gene promoters. The elucidation of these specific ...

Created: 17th Nov 2015 at 12:27   Last updated: 17th Nov 2015 at 12:28


 

Wordprocessing TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation


Authors: Jisen Huai, F-Nora Vögtle, Lars Jöckel, Yunbo Li, Thomas Kiefer, Jean-Ehrland Ricci, Christoph Borner

PubMed ID: 23788428

Date Published: 20th Jun 2013

Projects: No Projects

Journal: J. Cell. Sci.

Citation: J. Cell. Sci. 126(Pt 17): 4015-25

Scales: Not specified

Abstract (Expand)

When NF-κB activation or protein synthesis is inhibited, tumor necrosis factor alpha (TNFα) can induce apoptosis through Bax- and Bak-mediated mitochondrial outer membrane permeabilization (MOMP) leading ...

Created: 22nd Jan 2014 at 15:18


 

Wordprocessing The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy


Authors: Nikolaus Berndt, Hermann-Georg Holzhütter

PubMed ID: 23479331

Date Published: 13th Mar 2013

Projects: No Projects

Journal: Cell Biochem. Biophys.

Citation: Cell Biochem Biophys. 67(2):527-35

Scales: Not specified

Abstract (Expand)

It is estimated that maintenance of the resting potential of neurons consumes between 15 % (in gray matter) and 44 % (in fully myelinated white matter) of the brain's total energy budget [1]. This ...

Created: 6th May 2013 at 09:24   Last updated: 24th Oct 2013 at 16:14


 

Wordprocessing The Liver Toxicity Knowledge Base: A Systems Approach to a Complex End Point


Authors: M Chen, J Zhang, Y Wang, Z Liu, R Kelly, G Zhou, H Fang, J Borlak, W Tong

PubMed ID: 23486446

Date Published: 25th Jan 2013

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Clin. Pharmacol. Ther.

Citation: Clin. Pharmacol. Ther. 93(5): 409-12

Scales: Cell

Abstract:

Not specified

Created: 15th Mar 2013 at 14:16   Last updated: 24th Oct 2013 at 16:15


 

Wordprocessing The systems biology simulation core algorithm


Authors: Roland Keller, Alexander Dörr, Akito Tabira, Akira Funahashi, Michael J Ziller, Richard Adams, Nicolas Rodriguez, Nicolas Le Novère, Noriko Hiroi, Hannes Planatscher, Andreas Zell, Andreas Dräger

DOI: 10.1186/1752-0509-7-55

Date Published: 2013

Scales: Cell, Intercellular, Liver lobule, Liver and Organism

Abstract (Expand)

Background With the increasing availability of high dimensional time course data for metabolites, genes, and fluxes, the mathematical description of dynamical systems has become an essential aspect of ...

Created: 9th Jul 2013 at 04:12   Last updated: 24th Oct 2013 at 16:15


 

Wordprocessing The Extended TILAR Approach: A novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes


Authors: Sebastian Vlaic, Wolfgang Schmidt-Heck, Madlen Matz-Soja, Eugenia Marbach, Jörg Linde, Anke Meyer-Baese, Sebastian Zellmer, Reinhard Guthke, Rolf Gebhardt

PubMed ID: 23190768

Date Published: 29th Nov 2012

Scales: Cell

Abstract (Expand)

ABSTRACT: BACKGROUND: Network inference is an important tool to reveal the underlying interactions of biological systems. In the liver, a complex system of transcription factors is active to distribute ...

Created: 30th Nov 2012 at 14:57   Last updated: 24th Oct 2013 at 16:15


 

Wordprocessing The Process-Interaction-Model: a common representation of rule-based and logical models allows studying signal transduction on different levels of detail


Authors: Katrin Kolczyk, Regina Samaga, Holger Conzelmann, Sebastian Mirschel, Carsten Conradi

PubMed ID: 23020215

Date Published: 28th Sep 2012

Projects: E1: Integration on the cellular level

Journal: BMC Bioinformatics

Citation: BMC Bioinformatics 13: 251

Scales: Cell

Abstract (Expand)

Signaling systems typically involve large, structured molecules each consisting of a large number of subunits called molecule domains. In modeling such systems these domains can be considered as the ...

Created: 16th Jan 2014 at 11:29


 

Wordprocessing Tracing Fatty Acid Metabolism by Click Chemistry


Authors: Christoph Thiele, Cyrus Papan, Dominik Hoelper, Kalina Kusserow, Anne Gaebler, Mario Schoene, Kira Piotrowitz, Daniel Lohmann, Johanna Spandl, Ana Stevanovic, Andrej Shevchenko, Lars Kuerschner

PubMed ID: 22999348

Date Published: 25th Sep 2012

Projects: A1: Cellular metabolism

Journal: ACS Chem. Biol.

Citation: ACS Chem. Biol. 7(12): 2004-11

Scales: Cell

Abstract (Expand)

Fatty acids are abundant constituents of all biological systems, and their metabolism is important for normal function at all levels of an organism. Aberrations in fatty acid metabolism are associated ...

Created: 26th Oct 2012 at 16:36   Last updated: 24th Oct 2013 at 16:15


 

Wordprocessing Tissue proteomics by one-dimensional gel electrophoresis combined with label-free protein quantification


Authors: Andrej Vasilj, Marc Gentzel, Elke Ueberham, Rolf Gebhardt, Andrej Shevchenko

PubMed ID: 22671763

Date Published: 21st Jun 2012

Projects: A: Cellular level

Journal: J. Proteome Res.

Citation: J. Proteome Res. 11(7): 3680-9

Scales: Cell

Abstract (Expand)

Label-free methods streamline quantitative proteomics of tissues by alleviating the need for metabolic labeling of proteins with stable isotopes. Here we detail and implement solutions to common problems ...

Created: 20th Jul 2012 at 10:20   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing The promise and challenge of personalized medicine: aging populations, complex diseases, and unmet medical need


Author: Adriano M Henney

PubMed ID: 22661132

Date Published: 5th Jun 2012

Projects: Project Management, Virtual Liver

Journal: Croat. Med. J.

Citation: Croat. Med. J. 53(3): 207-10

Scales: Not specified

Abstract (Expand)

The concept of personalized medicine is not new. It is being discussed with increasing interest in the medical, scientific, and general media because of the availability of advanced scientific and ...

Created: 12th Jun 2012 at 10:11   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing Time-dependent intensity changes of free fatty acids detected by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry in the presence of 1,8-bis-(dimethylamino)naphthalene--a cautionary note


Authors: Mandy Eibisch, Rosmarie Süss, Jürgen Schiller

PubMed ID: 22638975

Date Published: 29th May 2012

Projects: No Projects

Journal: Rapid Commun. Mass Spectrom.

Citation: Rapid Commun. Mass Spectrom. 26(13): 1573-6

Scales: Not specified

Abstract:

Not specified

Created: 4th Aug 2012 at 16:26   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing TSSi--an R package for transcription start site identification from 5' mRNA tag data


Authors: C Kreutz, J S Gehring, D Lang, R Reski, J Timmer, S A Rensing

PubMed ID: 22513994

Date Published: 17th Apr 2012

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Journal: Bioinformatics

Citation: Bioinformatics 28(12): 1641-2

Scales: Cell

Abstract (Expand)

High-throughput sequencing has become an essential experimental approach for the investigation of transcriptional mechanisms. For some applications like ChIP-seq, several approaches for the prediction ...

Created: 8th Aug 2012 at 12:11   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity


Authors: Matthias Stein, Manohar Pilli, Sabine Bernauer, Bianca H Habermann, Marino Zerial, Rebecca C Wade

PubMed ID: 22523562

Date Published: 16th Apr 2012

Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...

Journal: PLoS ONE

Citation: PLoS ONE 7(4): e34870

Scales: Cell

Abstract (Expand)

Rab GTPases constitute the largest subfamily of the Ras protein superfamily. Rab proteins regulate organelle biogenesis and transport, and display distinct binding preferences for effector and activator ...

Created: 19th Jul 2012 at 09:45   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing Transcriptional regulators in hepatocarcinogenesis--key integrators of malignant transformation


Authors: Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn

PubMed ID: 22446689

Date Published: 21st Mar 2012

Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga...

Journal: J. Hepatol.

Citation: J. Hepatol. 57(1): 186-95

Scales: Not specified

Abstract (Expand)

Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies with poor prognosis and increasing incidence in the Western world. Only for a minority of HCC patients, surgical treatment ...

Created: 16th Jan 2013 at 09:04   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis


Authors: Johannes G Bode, Christian Ehlting, Dieter Häussinger

PubMed ID: 22330073

Date Published: 4th Feb 2012

Scales: Cell

Abstract (Expand)

In macrophages detection of gram-negative bacteria particularly involves binding of the outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising Toll like receptor 4 ...

Created: 31st Aug 2012 at 11:41   Last updated: 24th Oct 2013 at 16:17


 

Wordprocessing The virtual liver: a multidisciplinary, multilevel challenge for systems biology


Authors: Hermann-Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M Henney

PubMed ID: 22246674

Date Published: 13th Jan 2012

Projects: Virtual Liver

Journal: Wiley Interdiscip Rev Syst Biol Med

Citation: Wiley Interdiscip Rev Syst Biol Med 4(3): 221-35

Scales: Not specified

Abstract (Expand)

The liver is the central metabolic organ in human physiology, with functions that are fundamentally important to the detoxification of xenobiotics (drugs), the maintenance of homeostasis of numerous ...

Created: 19th Apr 2012 at 16:03   Last updated: 24th Oct 2013 at 16:17


 

Wordprocessing TGF-β in progression of liver disease


Authors: Steven Dooley, Peter ten Dijke

PubMed ID: 22006249

Date Published: 19th Oct 2011

Projects: B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., Show cases

Journal: Cell Tissue Res.

Citation: Cell Tissue Res. 347(1): 245-56

Scales: Not specified

Abstract (Expand)

Transforming growth factor-β (TGF-β) is a central regulator in chronic liver disease contributing to all stages of disease progression from initial liver injury through inflammation and fibrosis to ...

Created: 31st Oct 2012 at 08:42   Last updated: 24th Oct 2013 at 16:17


 

Wordprocessing Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease


Authors: Yijing Zhang, Kathrin Klein, Aarathi Sugathan, Najlla Nassery, Alan Dombkowski, Ulrich M Zanger, David J Waxman

PubMed ID: 21858147

Date Published: 12th Aug 2011

Projects: A3.4: Linking signalling to metabolic functions

Journal: PLoS ONE

Citation: PLoS ONE 6(8): e23506

Scales: Not specified

Abstract (Expand)

Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical ...

Created: 14th May 2012 at 09:54   Last updated: 24th Oct 2013 at 16:17


 

Wordprocessing The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice


Authors: Mirco Castoldi, Maja Vujic Spasic, Sandro Altamura, Joacim Elmén, Morten Lindow, Judit Kiss, Jens Stolte, Richard Sparla, Lorenza A D'Alessandro, Ursula Klingmüller, Robert E Fleming, Thomas Longerich, Hermann J Gröne, Vladimir Benes, Sakari Kauppinen, Matthias W Hentze, Martina U Muckenthaler

PubMed ID: 21364282

Date Published: 3rd Mar 2011

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: J. Clin. Invest.

Citation: J. Clin. Invest. 121(4): 1386-96

Scales: Cell, Liver and Organism

Abstract (Expand)

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. ...

Created: 11th Jul 2012 at 10:47   Last updated: 24th Oct 2013 at 16:19


 

Wordprocessing The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model


Authors: Nikolaus Berndt, Sabrina Hoffmann, Jan Benda, Hermann-Georg Holzhütter

PubMed ID: 21295041

Date Published: 2nd Feb 2011

Projects: No Projects

Journal: J. Theor. Biol.

Citation: J. Theor. Biol. 276(1): 42-9

Scales: Not specified

Abstract (Expand)

In excitable cells, the generation of an action potential (AP) is associated with transient changes of the intra- and extracellular concentrations of small ions such as Na(+), K(+) and Cl(-). If these ...

Created: 4th Jan 2013 at 11:22   Last updated: 24th Oct 2013 at 16:19


 

Wordprocessing Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner


Authors: Kathrin Schmich, Rebekka Schlatter, Nadia Corazza, Karine Sá Ferreira, Michael Ederer, Thomas Brunner, Christoph Borner, Irmgard Merfort

PubMed ID: 20872776

Date Published: 24th Sep 2010

Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...

Journal: Hepatology

Citation: Hepatology 53(1): 282-92

Scales: Cell and Intercellular

Abstract (Expand)

Fas/CD95 is a critical mediator of cell death in many chronic and acute liver diseases and induces apoptosis in primary hepatocytes in vitro. In contrast, the proinflammatory cytokine tumor necrosis ...

Created: 16th Jul 2012 at 16:53   Last updated: 24th Oct 2013 at 16:19


 

Wordprocessing Two to tango: regulation of Mammalian iron metabolism


Authors: Matthias W Hentze, Martina U Muckenthaler, Bruno Galy, Clara Camaschella

PubMed ID: 20603012

Date Published: 7th Jul 2010

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys

Journal: Cell

Citation: Cell 142(1): 24-38

Scales: Cell

Abstract (Expand)

Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions ...

Created: 29th Oct 2012 at 11:04   Last updated: 24th Oct 2013 at 16:20


 

Wordprocessing The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver


Authors: Peggy Stock, Sandra Brückner, Sabine Ebensing, Madlen Hempel, Matthias M Dollinger, Bruno Christ

PubMed ID: 20224562

Date Published: 11th Mar 2010

Projects: C6: Organization and function of the sinusoidal system and the liver lob...

Journal: Nat Protoc

Citation: Nat Protoc 5(4): 617-27

Scales: Liver

Abstract (Expand)

Donor organ shortage is still the major obstacle for the clinical application of hepatocyte transplantation in the treatment of liver diseases. However, generation of hepatocyte-like cells from mesenchymal ...

Created: 14th Jan 2014 at 10:13


 

Wordprocessing Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes


Authors: Sebastian Zellmer, Wolfgang Schmidt-Heck, Patricio Godoy, Honglei Weng, Christoph Meyer, Thomas Lehmann, Titus Sparna, Wiebke Schormann, Seddik Hammad, Clemens Kreutz, Jens Timmer, Fritz von Weizsäcker, Petra A Thürmann, Irmgard Merfort, Reinhard Guthke, Steven Dooley, Jan G Hengstler, Rolf Gebhardt

PubMed ID: 20979052

Date Published: 5th Mar 2010

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: Hepatology

Citation: Hepatology 52(6): 2127-36

Scales: Not specified

Abstract (Expand)

The cellular basis of liver regeneration has been intensely investigated for many years. However, the mechanisms initiating hepatocyte "plasticity" and priming for proliferation are not yet ...

Created: 13th Dec 2010 at 11:21   Last updated: 24th Oct 2013 at 16:20


 

Wordprocessing The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays


Authors: Yevhen Vainshtein, Mayka Sanchez, Alvis Brazma, Matthias W Hentze, Thomas Dandekar, Martina U Muckenthaler

PubMed ID: 20193060

Date Published: 1st Mar 2010

Projects: HepatoSys

Journal: BMC Bioinformatics

Citation: BMC Bioinformatics 11: 112

Scales: Not specified

Abstract (Expand)

Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations are limiting ...

Created: 30th Oct 2012 at 08:53   Last updated: 24th Oct 2013 at 16:20


 

Wordprocessing The speciation of the proteome


Authors: Peter R Jungblut, Hermann G Holzhütter, Rolf Apweiler, Hartmut Schlüter

PubMed ID: 18638390

Date Published: 18th Jul 2008

Projects: No Projects

Journal: Chem Cent J

Citation: Chem Cent J 2: 16

Scales: Not specified

Abstract (Expand)

In proteomics a paradox situation developed in the last years. At one side it is basic knowledge that proteins are post-translationally modified and occur in different isoforms. At the other side the ...

Created: 4th Jan 2013 at 13:00   Last updated: 24th Oct 2013 at 16:22



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