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Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma

Authors: Stefan Welte, Toni Urbanik, Christin Elßner, Nicole Kautz, Bruno Christian Koehler, Nina Waldburger, Justo Lorenzo Bermejo, Federico Pinna, Karl-Heinz Weiss, Peter Schemmer, Dirk Jaeger, Thomas Longerich, Kai Breuhahn, Henning Schulze-Bergkamen

DOI: 10.1371/journal.pone.0110591

Date Published: 16th Oct 2014

Projects: A2.1: Multi-level regulation of signalling pathways important for primin...

Journal: PLoS ONE

Citation: PLoS ONE 9(10) : e110591

Scales: Cell

Abstract:

Not specified

Created: 20th Jan 2015 at 13:44 Last updated: 20th Jan 2015 at 13:46

No activation of human PXR by hyperforin-related phloroglucinols

Authors: Benjamin A Kandel, Sean Ekins, Kristina Leuner, Wolfgang E Thasler, Christian Harteneck, Ulrich M Zanger

PubMed ID: 24259679

Date Published: 22nd Nov 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: J. Pharmacol. Exp. Ther.

Citation: J. Pharmacol. Exp. Ther. :

Scales: Not specified

Abstract (Expand)

The acylated phloroglucinol, hyperforin, the main active ingredient of St John's wort, exerts anti-depressant properties via indirect inhibition of serotonin reuptake by selectively activating the ...

Created: 8th Jan 2014 at 13:53

Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration

Authors: Rania Dayoub, Arndt Vogel, Jutta Schuett, Madeleine Lupke, Susannah M Spieker, Nadja Kettern, Eberhard Hildt, Michael Melter, Thomas S Weiss

PubMed ID: 23887691

Date Published: 23rd Jul 2013

Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., CTU SOP Human Hepatocytes

Journal: Mol. Med.

Citation: Mol. Med. 19: 237-44

Scales: Cell and Liver

Abstract (Expand)

Liver regeneration can be impaired by permanent oxidative stress and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), known to regulate the cellular antioxidant response, and has been ...

Created: 30th Jan 2014 at 17:06

Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools

Authors: Robert Radloff, Alain Gras, Ulrich M Zanger, Cécile Masquelier, Karthik Arumugam, Jean-Claude Karasi, Vic Arendt, Carole Seguin-Devaux, Kathrin Klein

PubMed ID: 23418033

Date Published: 11th Mar 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Hum. Mutat.

Citation: Hum. Mutat. 34(5): 725-34

Scales: Not specified

Abstract (Expand)

Cytochrome P450 CYP2B6 is a highly polymorphic enzyme that metabolizes numerous drugs, pesticides, and environmental toxins. Sequence analysis of a Rwandese population identified eight functionally ...

Created: 13th Jan 2014 at 10:17

Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism

Authors: Susanna Bazzani, Andreas Hoppe, Hermann-Georg Holzhütter

PubMed ID: 22937810

Date Published: 31st Aug 2012

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: BMC Syst Biol

Citation: BMC Syst Biol 6: 118

Scales: Cell

Abstract (Expand)

ABSTRACT: BACKGROUND: The search for new drug targets for antibiotics against Plasmodium falciparum, a major cause of human deaths, is a pressing scientific issue, as multiple resistance strains spread ...

Created: 16th Nov 2012 at 14:21 Last updated: 24th Oct 2013 at 16:16

Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice

Authors: Indumathi Chennamsetty, Karam M Kostner, Thierry Claudel, Manjula Vinod, Sasa Frank, Thomas S Weiss, Michael Trauner, Gerhard M Kostner

PubMed ID: 22930813

Date Published: 28th Aug 2012

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., CTU SOP Human Hepatocytes

Journal: J. Lipid Res.

Citation: J. Lipid Res. 53(11): 2405-12

Scales: Cell and Liver

Abstract (Expand)

Elevated plasma lipoprotein(a) (LPA) levels are recognized as an independent risk factor for cardiovascular diseases. Our knowledge on LPA metabolism is incomplete, which makes it difficult to develop ...

Created: 30th Jan 2014 at 17:14

Normalization And Matching Of Chemical Compound Names

Authors: Martin Golebiewski, Martin Golebiewski, Meik Bittkowski, Henriette Slogsnat, Jasmin Saric, Isabel Rojas, Wolfgang Müller

DOI: 10.1038/npre.2011.6505.1

Date Published: 7th Oct 2011

Projects: F1: The data management system

Journal: Nature Precedings

Citation: Nature Precedings

Scales: Not specified

Abstract:

Not specified

Created: 13th Jul 2012 at 14:34 Last updated: 24th Oct 2013 at 16:17

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development

Authors: Malte Paulsen, Stefan Legewie, Roland Eils, Emil Karaulanov, Christof Niehrs

PubMed ID: 21633009

Date Published: 1st Jun 2011

Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Proc. Natl. Acad. Sci. U.S.A.

Citation: Proc. Natl. Acad. Sci. U.S.A. 108(25): 10202-7

Scales: Cell

Abstract (Expand)

What makes embryogenesis a robust and canalized process is an important question in developmental biology. A bone morphogenetic protein (BMP) morphogen gradient plays a key role in embryonic development, ...

Created: 11th Sep 2012 at 11:36 Last updated: 24th Oct 2013 at 16:18

Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes

Authors: A Garten, S Petzold, A Barnikol-Oettler, A Körner, W E Thasler, J Kratzsch, W Kiess, R Gebhardt

PubMed ID: 19912992

Date Published: 11th Nov 2009

Projects: Showcase Steatosis

Journal: Biochem. Biophys. Res. Commun.

Citation: Biochem. Biophys. Res. Commun. 391(1): 376-81

Scales: Cell

Abstract (Expand)

Circulating NAMPT (PBEF/visfatin) has pleiotropic functions and is secreted from adipocytes. Since it is doubtful whether serum levels can be explained by secretion from adipocytes alone, we asked ...

Created: 20th Jul 2012 at 10:11 Last updated: 24th Oct 2013 at 16:21