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Intrahepatic Size Regulation in a Surgical Model: Liver Resection-Induced Liver Regeneration Counteracts the Local Atrophy following Simultaneous Portal Vein Ligation

Authors: Weiwei Wei, Tianjiao Zhang, Haoshu Fang, Olaf Dirsch, Andrea Schenk, André Homeyer, Felix Gremse, Sara Zafarnia, Utz Settmacher, Uta Dahmen

DOI: 10.1159/000446875

Date Published: 5th Jul 2016

Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale

Journal: Eur Surg Res

Citation: Eur Surg Res 57(1-2) : 125

Scales: Liver

Abstract (Expand)

Background/Aim: Liver size regulation is based on the balance between hepatic regeneration and atrophy. To achieve a better understanding of intrahepatic size regulation, we explored the size regulation ...

Created: 26th May 2017 at 10:43 Last updated: 26th May 2017 at 10:45

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

Authors: J. Zhang, K. He, L. Cai, Y. C. Chen, Y. Yang, Q. Shi, T. F. Woolf, W. Ge, L. Guo, J. Borlak, W. Tong

PubMed ID: 27000539

Date Published: 24th Mar 2016

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: Chem Biol Interact

Citation: Chem Biol Interact. 2016 Mar 19. pii: S0009-2797(16)30089-8. doi: 10.1016/j.cbi.2016.03.019.

Scales: Cell

Abstract (Expand)

Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of ...

Created: 18th May 2016 at 10:56

Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice

Authors: E. H. Lee, J. H. Oh, S. Selvaraj, S. M. Park, M. S. Choi, R. Spanel, S. Yoon, J. Borlak

PubMed ID: 26934552

Date Published: 5th Mar 2016

Projects: A3.6: Transcription factor network and links to metabolism in NAFLD

Journal: Oncotarget

Citation: Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7698.

Scales: Liver

Abstract (Expand)

Diclofenac is a non-steroidal anti-inflammatory drug and its use can be associated with severe adverse reactions, notably myocardial infarction, stroke and drug-induced liver injury (DILI). In pursue ...

Created: 18th May 2016 at 10:52

Intrahepatic Vascular Anatomy in Rats and Mice—Variations and Surgical Implications

Authors: Constanze Sänger, Andrea Schenk, Lars Ole Schwen, Lei Wang, Felix Gremse, Sara Zafarnia, Fabian Kiessling, Chichi Xie, Weiwei Wei, Beate Richter, Olaf Dirsch, Uta Dahmen

DOI: 10.1371/journal.pone.0141798

Date Published: 30th Nov 2015

Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales

Journal: PLoS ONE

Citation: PLoS ONE 10(11) : e0141798

Scales: Liver

Abstract (Expand)

Introduction The intra-hepatic vascular anatomy in rodents, its variations and corresponding supplying and draining territories in respect to the lobar structure of the liver have not been described. ...

Created: 13th Jan 2016 at 08:00 Last updated: 13th Jan 2016 at 08:03

Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe

Authors: F. Malentacchi, I. Mancini, I. Brandslund, P. Vermeersch, M. Schwab, J. Marc, R. H. van Schaik, G. Siest, E. Theodorsson, M. Pazzagli, C. Di Resta

PubMed ID: 26036226

Date Published: 4th Jun 2015

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Drug Metabol Personal Ther

Citation: Drug Metabol Personal Ther. 2015 Jun;30(2):121-8. doi: 10.1515/dmdi-2015-0012.

Scales: Not specified

Abstract (Expand)

Developments in "-omics" are creating a paradigm shift in laboratory medicine leading to personalized medicine. This allows the increase in diagnostics and therapeutics focused on individuals ...

Created: 17th Dec 2015 at 11:44

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

Authors: S. Wolking, E. Schaeffeler, H. Lerche, M. Schwab, A. T. Nies

PubMed ID: 25860377

Date Published: 11th Apr 2015

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Clin Pharmacokinet

Citation: Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1.

Scales: Not specified

Abstract (Expand)

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1) is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma membrane of many different ...

Created: 17th Dec 2015 at 11:51

Implementation of systems theory in liver cancer research

Authors: Federico Pinna, Kai Breuhahn

DOI: 10.2217/hep.14.29

Date Published: 2015

Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga...

Journal: Hepatic Oncology

Citation: Hepatic Oncology 2(1) : 9

Scales: Cell and Intercellular

Abstract:

Not specified

Created: 20th Jan 2015 at 13:49 Last updated: 20th Jan 2015 at 13:52

Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes

Authors: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort

DOI: 10.1371/journal.pone.0115603

Date Published: 31st Dec 2014

Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...

Journal: PLoS ONE

Citation: PLoS ONE 9(12) : e115603

Scales: Cell

Abstract (Expand)

Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes ...

Created: 23rd Jan 2015 at 09:58 Last updated: 23rd Jan 2015 at 10:00

Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells

Authors: Elisa Pfeiffer, Victoria Kegel, Katrin Zeilinger, Jan G Hengstler, Andreas K Nüssler, Daniel Seehofer, Georg Damm

PubMed ID: 25394621

Date Published: 15th Nov 2014

Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., CTU Liver bank

Journal: Exp. Biol. Med. (Maywood)

Citation: Exp. Biol. Med. (Maywood) :

Scales: Cell and Intercellular

Abstract (Expand)

Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH cultivation in 2D mono-cultures leads to dedifferentiation ...

Created: 5th Jan 2015 at 13:19

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6

Authors: Michael H Court, Fawziah E Almutairi, David J Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M Zanger, Joanne Bourgea, Christopher J Patten, Awewura Kwara

PubMed ID: 24820076

Date Published: 12th May 2014

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G: Clinical translation

Journal: Antimicrob. Agents Chemother.

Citation: Antimicrob. Agents Chemother. 58(7): 4145-52

Scales: Not specified

Abstract (Expand)

Efavirenz is commonly used to treat patients coinfected with human immunodeficiency virus and tuberculosis. Previous clinical studies have observed paradoxically elevated efavirenz plasma concentrations ...

Created: 8th Dec 2014 at 09:49

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

Authors: Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer

DOI: 10.1002/hep.27136

Date Published: 1st May 2014

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.4: Linking signalling to metabolic functions

Journal: Hepatology

Citation: Hepatology : n/a

Scales: Not specified

Abstract:

Not specified

Created: 7th Nov 2014 at 15:12 Last updated: 7th Nov 2014 at 15:12

Isolation of human hepatocytes by a two-step collagenase perfusion procedure

Authors: Serene M L Lee, Celine Schelcher, Maresa Demmel, Maria Hauner, Wolfgang E Thasler

PubMed ID: 24056912

Date Published: 24th Sep 2013

Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, CTUs, Show cases, Virtual Liver

Journal: J Vis Exp

Citation: J Vis Exp (79):

Scales: Cell

Abstract (Expand)

The liver, an organ with an exceptional regeneration capacity, carries out a wide range of functions, such as detoxification, metabolism and homeostasis. As such, hepatocytes are an important model for ...

Created: 13th Jan 2014 at 15:48

Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis

Authors: Nikolaus Berndt, Herrmann-Georg Holzhütter, Sascha Bulik

PubMed ID: 23937586

Date Published: 12th Sep 2013

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: FEBS J.

Citation: FEBS J. 280(20): 5080-93

Scales: Not specified

Abstract (Expand)

Steadily growing experimental evidence suggests that mitochondrial dysfunction plays a key role in the age-dependent impairment of nerve cells underlying several neurodegenerative diseases. In particular, ...

Created: 20th Jan 2014 at 10:41

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Authors: Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin Maier, Marino Zerial

PubMed ID: 23792630

Date Published: 23rd Jun 2013

Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...

Journal: Nat. Biotechnol.

Citation: Nat. Biotechnol. 31(7): 638-46

Scales: Cell, Intercellular and Liver

Abstract (Expand)

Delivery of short interfering RNAs (siRNAs) remains a key challenge in the development of RNA interference (RNAi) therapeutics. A better understanding of the mechanisms of siRNA cellular uptake, ...

Created: 15th Jul 2013 at 11:10 Last updated: 24th Oct 2013 at 16:14

Isolation and hepatocyte differentiation of mesenchymal stem cells from porcine bone marrow--"surgical waste" as a novel MSC source

Authors: S Brückner, H-M Tautenhahn, S Winkler, P Stock, S Jonas, M Dollinger, B Christ

PubMed ID: 23769107

Date Published: 19th Jun 2013

Projects: C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase Steatosis

Journal: Transplant. Proc.

Citation: Transplant. Proc. 45(5): 2056-8

Scales: Organism

Abstract (Expand)

Mesenchymal stem cells (MSC) isolated from bone marrow and differentiated into hepatocyte-like cells have increasingly gained attention for clinical cell therapy of liver diseases because of their high ...

Created: 19th Nov 2013 at 11:47

Iron regulatory proteins control a mucosal block to intestinal iron absorption

Authors: Bruno Galy, Dunja Ferring-Appel, Christiane Becker, Norbert Gretz, Hermann-Josef Gröne, Klaus Schümann, Matthias W Hentze

PubMed ID: 23523353

Date Published: 21st Mar 2013

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Journal: Cell Rep

Citation: Cell Rep 3(3): 844-57

Scales: Not specified

Abstract (Expand)

Mammalian iron metabolism is regulated systemically by the hormone hepcidin and cellularly by iron regulatory proteins (IRPs) that orchestrate a posttranscriptional regulatory network. Through ...

Created: 14th Jan 2014 at 14:38

Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0

Authors: Michael Weber, Sebastian G Henkel, Sebastian Vlaic, Reinhard Guthke, Everardus J van Zoelen, Dominik Driesch

DOI: 10.1186/1752-0509-7-1

Date Published: 2013

Projects: Virtual Liver

Journal: BMC Syst Biol

Citation: BMC Syst Biol 7(1) : 1

Scales: Not specified

Abstract (Expand)

BACKGROUND Inference of gene-regulatory networks (GRNs) is important for understanding behaviour and potential treatment of biological systems. Knowledge about GRNs gained from transcriptome analysis ...

Created: 2nd Jan 2013 at 10:24 Last updated: 24th Oct 2013 at 16:15

Implication of hepatic stem cells in functional liver repopulation

Authors: Bruno Christ, Sandra Pelz

PubMed ID: 23184585

Date Published: 26th Nov 2012

Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase HGF and Regeneration

Journal: Cytometry A

Citation: Cytometry A 83(1): 90-102

Scales: Cell and Liver

Abstract (Expand)

The liver has an enormous potential to restore the parenchymal tissue loss due to injury. This is accomplished by the proliferation of either the hepatocytes or liver progenitor cells in cases where ...

Created: 19th Nov 2013 at 11:52

Integrating Cellular Metabolism into a Multiscale Whole-Body Model

Authors: Markus Krauss, Stephan Schaller, Steffen Borchers, Rolf Findeisen, Jörg Lippert, Lars Kuepfer

DOI: 10.1371/journal.pcbi.1002750

Date Published: 25th Oct 2012

Projects: E4: Vertical integration across biological scales, E: Model integration

Journal: PLoS Comput Biol

Citation: PLoS Comput Biol 8(10) : e1002750

Scales: Cell, Liver and Organism

Abstract (Expand)

Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology. The multifaceted physiological role of ...

Created: 29th Oct 2012 at 12:17 Last updated: 24th Oct 2013 at 16:15

Identification of RARRES1 as a core regulator in liver fibrosis

Authors: Andreas Teufel, Diana Becker, Susanne N Weber, Steven Dooley, Katja Breitkopf-Heinlein, Thorsten Maass, Katrin Hochrath, Markus Krupp, Jens U Marquardt, Martin Kolb, Bernhard Korn, Christof Niehrs, Tim Zimmermann, Patricio Godoy, Peter R Galle, Frank Lammert

PubMed ID: 22669512

Date Published: 6th Jun 2012

Projects: B2.1: Hepatic stellate cells as source and target for hepatocellular gro...

Journal: Journal of molecular medicine (Berlin, Germany)

Citation: J. Mol. Med. 90(12): 1439-47

Scales: Not specified

Abstract (Expand)

Genetic factors contribute to progression and modulation of hepatic fibrosis. High throughput genomics/transcriptomics approaches aiming at identifying key regulators of fibrosis development are tainted ...

Created: 31st Jul 2012 at 11:24 Last updated: 24th Oct 2013 at 16:16

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

Authors: Katrin Straßburger, Marcel Tiebe, Federico Pinna, Kai Breuhahn, Aurelio A Teleman

PubMed ID: 22609549

Date Published: 16th May 2012

Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga...

Journal: Dev. Biol.

Citation: Dev. Biol. 367(2): 187-96

Scales: Cell

Abstract (Expand)

The insulin/IGF signaling (IIS) pathway is a potent inducer of cell proliferation in normal development and in cancer. The mechanism by which this occurs, however, is not completely understood. The ...

Created: 16th Jan 2013 at 09:03 Last updated: 24th Oct 2013 at 16:16

Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection

Authors: Dechun Feng, Xiaoni Kong, Honglei Weng, Ogyi Park, Hua Wang, Steven Dooley, M Eric Gershwin, Bin Gao

PubMed ID: 22484119

Date Published: 3rd Apr 2012

Projects: Showcase LPS and Inflammation

Journal: Gastroenterology

Citation: Gastroenterology 143(1): 188-98.e7

Scales: Not specified

Abstract (Expand)

Proliferation of liver stem/progenitor cells (LPCs), which can differentiate into hepatocytes or biliary epithelial cells, is often observed in chronically inflamed regions of liver in patients. We ...

Created: 31st Oct 2012 at 09:09 Last updated: 24th Oct 2013 at 16:16

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems

Authors: Thomas Maiwald, Julie Blumberg, Andreas Raue, Stefan Hengl, Marcel Schilling, Sherwin Kb Sy, Verena Becker, Ursula Klingmüller, Jens Timmer

PubMed ID: 22369292

Date Published: 27th Feb 2012

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Journal: BMC Syst Biol

Citation: BMC Syst Biol 6: 13

Scales: Cell

Abstract:

ABSTRACT:

Created: 10th Aug 2012 at 09:33 Last updated: 24th Oct 2013 at 16:16

Integration of Boolean models exemplified on hepatocyte signal transduction

Authors: Rebekka Schlatter, Nicole Philippi, Gaby Wangorsch, Robert Pick, Oliver Sawodny, Christoph Borner, Jens Timmer, Michael Ederer, Thomas Dandekar

PubMed ID: 22016404

Date Published: 20th Oct 2011

Projects: No Projects

Journal: Brief. Bioinformatics

Citation: Brief. Bioinformatics 13(3): 365-76

Scales: Not specified

Abstract (Expand)

The number of mathematical models for biological pathways is rapidly growing. In particular, Boolean modelling proved to be suited to describe large cellular signalling networks. Systems biology is at ...

Created: 22nd Jan 2014 at 15:26

Integration of Boolean models exemplified on hepatocyte signal transduction

Authors: Rebekka Schlatter, Nicole Philippi, Gaby Wangorsch, Robert Pick, Oliver Sawodny, Christoph Borner, Jens Timmer, Michael Ederer, Thomas Dandekar

PubMed ID: 22016404

Date Published: 20th Oct 2011

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response, B1.1: Differential communication of wound healing and hepatoxic macropha...

Journal: Brief. Bioinformatics

Citation: Brief. Bioinformatics 13(3): 365-76

Scales: Cell

Abstract (Expand)

Created: 8th Aug 2012 at 12:07 Last updated: 24th Oct 2013 at 16:17

In silico evidence for gluconeogenesis from fatty acids in humans

Authors: Christoph Kaleta, Luís F de Figueiredo, Sarah Werner, Reinhard Guthke, Michael Ristow, Stefan Schuster

PubMed ID: 21814506

Date Published: 21st Jul 2011

Projects: HepatoSys

Journal: PLoS Comput. Biol.

Citation: PLoS Comput. Biol. 7(7): e1002116

Scales: Not specified

Abstract (Expand)

The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is "No". Using recent advances in Systems Biology ...

Created: 18th Jul 2012 at 08:43 Last updated: 24th Oct 2013 at 16:18

Inferring statin-induced gene regulatory relationships in primary human hepatocytes

Authors: Adrian Schröder, Johannes Wollnik, Clemens Wrzodek, Andreas Dräger, Michael Bonin, Oliver Burk, Maria Thomas, Wolfgang E Thasler, Ulrich M Zanger, Andreas Zell

PubMed ID: 21757465

Date Published: 16th Jul 2011

Projects: B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Bioinformatics

Citation: Bioinformatics 27(18): 2473-7

Scales: Not specified

Abstract (Expand)

MOTIVATION: Statins are the most widely used cholesterol-lowering drugs. The primary target of statins is HMG-CoA reductase, a key enzyme in cholesterol synthesis. However, statins elicit pleitropic ...

Created: 28th Jul 2011 at 18:15 Last updated: 24th Oct 2013 at 16:18

Inferring transcriptional regulators for sets of co-expressed genes by multi-objective evolutionary optimization

Authors: Adrian Schroder, Clemens Wrzodek, Johannes Wollnik, Andreas Drager, Dierk Wanke, Kenneth W Berendzen, Andreas Zell

DOI: 10.1109/CEC.2011.5949899

Date Published: 1st Jun 2011

Projects: A3.4: Linking signalling to metabolic functions

Conference: 2011 IEEE Congress of Evolutionary Computation (CEC)

Citation: Inferring transcriptional regulators for sets of co-expressed genes by multi-objective evolutionary optimization : 2285

Scales: Intercellular

Abstract (Expand)

Higher organisms are able to respond to continuously changing external conditions by transducing cellular signals into specific regulatory programs, which control gene expression states of thousands ...

Created: 9th Jan 2012 at 13:53 Last updated: 24th Oct 2013 at 16:18

Identifiability and observability analysis for experimental design in nonlinear dynamical models

Authors: A Raue, V Becker, U Klingmüller, J Timmer

PubMed ID: 21198117

Date Published: 5th Jan 2011

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Journal: Chaos

Citation: Chaos 20(4): 045105

Scales: Cell

Abstract (Expand)

Dynamical models of cellular processes promise to yield new insights into the underlying systems and their biological interpretation. The processes are usually nonlinear, high dimensional, and time-resolved ...

Created: 10th Aug 2012 at 09:43 Last updated: 24th Oct 2013 at 16:19

Iron regulatory proteins secure mitochondrial iron sufficiency and function

Authors: Bruno Galy, Dunja Ferring-Appel, Sven W Sauer, Sylvia Kaden, Saïd Lyoumi, Herve Puy, Stefan Kölker, Hermann-Josef Gröne, Matthias W Hentze

PubMed ID: 20674864

Date Published: 3rd Aug 2010

Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys

Journal: Cell Metab.

Citation: Cell Metab. 12(2): 194-201

Scales: Cell

Abstract (Expand)

Mitochondria supply cells with ATP, heme, and iron sulfur clusters (ISC), and mitochondrial energy metabolism involves both heme- and ISC-dependent enzymes. Here, we show that mitochondrial iron supply ...

Created: 29th Oct 2012 at 11:00 Last updated: 24th Oct 2013 at 16:20

IGERS: inferring Gibbs energy changes of biochemical reactions from reaction similarities

Authors: Kristian Rother, Sabrina Hoffmann, Sascha Bulik, Andreas Hoppe, Johann Gasteiger, Herrmann-Georg Holzhütter

PubMed ID: 20513391

Date Published: 2nd Jun 2010

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: Biophys. J.

Citation: Biophys. J. 98(11): 2478-86

Scales: Not specified

Abstract (Expand)

Mathematical analysis and modeling of biochemical reaction networks requires knowledge of the permitted directionality of reactions and membrane transport processes. This information can be gathered ...

Created: 4th Jan 2013 at 10:51 Last updated: 24th Oct 2013 at 16:20

Interpretation of non-invasive breath tests using (13)C-labeled substrates--a preliminary report with (13)C-methacetin

Authors: J F Lock, P Taheri, S Bauer, H-G Holzhütter, M Malinowski, P Neuhaus, M Stockmann

PubMed ID: 20149989

Date Published: 13th Feb 2010

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Eur. J. Med. Res.

Citation: Eur. J. Med. Res. 14: 547-50

Scales: Not specified

Abstract (Expand)

Non-invasive breath tests can serve as valuable diagnostic tools in medicine as they can determine particular enzymatic and metabolic functions in vivo. However, methodological pitfalls have limited ...

Created: 8th Jan 2013 at 11:53 Last updated: 24th Oct 2013 at 16:20

Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis

Authors: Frank Götschel, Claudia Kern, Simona Lang, Titus Sparna, Cordula Markmann, Joseph Schwager, Sabine McNelly, Fritz von Weizsäcker, Stefan Laufer, Andreas Hecht, Irmgard Merfort

PubMed ID: 18261723

Date Published: 31st Dec 2007

Projects: HepatoSys

Journal: Exp. Cell Res.

Citation: Exp. Cell Res. 314(6): 1351-66

Scales: Cell

Abstract (Expand)

Glycogen synthase kinase-3 (GSK-3) is known to modulate cell survival and apoptosis through multiple intracellular signaling pathways. However, its hepatoprotective function and its role in activation ...

Created: 30th Aug 2012 at 12:33 Last updated: 24th Oct 2013 at 16:23

Integration of SABIO-RK in workbenches for kinetic model design

Authors: Martin Golebiewski, Saqib Mir, Renate Kania, Olga Krebs, Andreas Weidemann, Ulrike Wittig, Isabel Rojas

DOI: 10.1186/1752-0509-1-S1-P4

Date Published: 2007

Projects: F3: Kinetic data handling

Journal: BMC Syst Biol

Citation: BMC Syst Biol 1(Suppl 1) : P4

Scales: Not specified

Abstract:

Not specified

Created: 11th Nov 2010 at 18:36 Last updated: 24th Oct 2013 at 16:23