Publications
Intrahepatic Size Regulation in a Surgical Model: Liver Resection-Induced Liver Regeneration Counteracts the Local Atrophy following Simultaneous Portal Vein Ligation
Authors: Weiwei Wei, Tianjiao Zhang, Haoshu Fang, Olaf Dirsch, Andrea Schenk, André Homeyer, Felix Gremse, Sara Zafarnia, Utz Settmacher, Uta Dahmen
DOI: 10.1159/000446875
Date Published: 5th Jul 2016
Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale
Journal: Eur Surg Res
Citation: Eur Surg Res 57(1-2) : 125
Scales: Liver
Abstract (Expand)
Created: 26th May 2017 at 10:43  Last updated: 26th May 2017 at 10:45
Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse
Authors: J. Zhang, K. He, L. Cai, Y. C. Chen, Y. Yang, Q. Shi, T. F. Woolf, W. Ge, L. Guo, J. Borlak, W. Tong
PubMed ID: 27000539
Date Published: 24th Mar 2016
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Chem Biol Interact
Citation: Chem Biol Interact. 2016 Mar 19. pii: S0009-2797(16)30089-8. doi: 10.1016/j.cbi.2016.03.019.
Authors: E. H. Lee, J. H. Oh, S. Selvaraj, S. M. Park, M. S. Choi, R. Spanel, S. Yoon, J. Borlak
PubMed ID: 26934552
Date Published: 5th Mar 2016
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Oncotarget
Citation: Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7698.
Authors: Constanze Sänger, Andrea Schenk, Lars Ole Schwen, Lei Wang, Felix Gremse, Sara Zafarnia, Fabian Kiessling, Chichi Xie, Weiwei Wei, Beate Richter, Olaf Dirsch, Uta Dahmen
DOI: 10.1371/journal.pone.0141798
Date Published: 30th Nov 2015
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: PLoS ONE
Citation: PLoS ONE 10(11) : e0141798
Scales: Liver
Abstract (Expand)
Created: 13th Jan 2016 at 08:00  Last updated: 13th Jan 2016 at 08:03
Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe
Authors: F. Malentacchi, I. Mancini, I. Brandslund, P. Vermeersch, M. Schwab, J. Marc, R. H. van Schaik, G. Siest, E. Theodorsson, M. Pazzagli, C. Di Resta
PubMed ID: 26036226
Date Published: 4th Jun 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Drug Metabol Personal Ther
Citation: Drug Metabol Personal Ther. 2015 Jun;30(2):121-8. doi: 10.1515/dmdi-2015-0012.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:44
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
Authors: S. Wolking, E. Schaeffeler, H. Lerche, M. Schwab, A. T. Nies
PubMed ID: 25860377
Date Published: 11th Apr 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacokinet
Citation: Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:51
Authors: Federico Pinna, Kai Breuhahn
DOI: 10.2217/hep.14.29
Date Published: 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga...
Journal: Hepatic Oncology
Citation: Hepatic Oncology 2(1) : 9
Scales: Cell and Intercellular
Abstract:
Created: 20th Jan 2015 at 13:49  Last updated: 20th Jan 2015 at 13:52
Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes
Authors: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort
DOI: 10.1371/journal.pone.0115603
Date Published: 31st Dec 2014
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 9(12) : e115603
Scales: Cell
Abstract (Expand)
Created: 23rd Jan 2015 at 09:58  Last updated: 23rd Jan 2015 at 10:00
Authors: Elisa Pfeiffer, Victoria Kegel, Katrin Zeilinger, Jan G Hengstler, Andreas K Nüssler, Daniel Seehofer, Georg Damm
PubMed ID: 25394621
Date Published: 15th Nov 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., CTU Liver bank
Journal: Exp. Biol. Med. (Maywood)
Citation: Exp. Biol. Med. (Maywood) :
Scales: Cell and Intercellular
Abstract (Expand)
Created: 5th Jan 2015 at 13:19
Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6
Authors: Michael H Court, Fawziah E Almutairi, David J Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M Zanger, Joanne Bourgea, Christopher J Patten, Awewura Kwara
PubMed ID: 24820076
Date Published: 12th May 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G: Clinical translation
Journal: Antimicrob. Agents Chemother.
Citation: Antimicrob. Agents Chemother. 58(7): 4145-52
Scales: Not specified
Abstract (Expand)
Created: 8th Dec 2014 at 09:49
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
Authors: Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer
DOI: 10.1002/hep.27136
Date Published: 1st May 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.4: Linking signalling to metabolic functions
Journal: Hepatology
Citation: Hepatology : n/a
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:12  Last updated: 7th Nov 2014 at 15:12
Authors: Serene M L Lee, Celine Schelcher, Maresa Demmel, Maria Hauner, Wolfgang E Thasler
PubMed ID: 24056912
Date Published: 24th Sep 2013
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, CTUs, Show cases, Virtual Liver
Journal: J Vis Exp
Citation: J Vis Exp (79):
Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis
Authors: Nikolaus Berndt, Herrmann-Georg Holzhütter, Sascha Bulik
PubMed ID: 23937586
Date Published: 12th Sep 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: FEBS J.
Citation: FEBS J. 280(20): 5080-93
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 10:41
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape
Authors: Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin Maier, Marino Zerial
PubMed ID: 23792630
Date Published: 23rd Jun 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Nat. Biotechnol.
Citation: Nat. Biotechnol. 31(7): 638-46
Scales: Cell, Intercellular and Liver
Abstract (Expand)
Created: 15th Jul 2013 at 11:10  Last updated: 24th Oct 2013 at 16:14
Isolation and hepatocyte differentiation of mesenchymal stem cells from porcine bone marrow--"surgical waste" as a novel MSC source
Authors: S Brückner, H-M Tautenhahn, S Winkler, P Stock, S Jonas, M Dollinger, B Christ
PubMed ID: 23769107
Date Published: 19th Jun 2013
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase Steatosis
Journal: Transplant. Proc.
Citation: Transplant. Proc. 45(5): 2056-8
Authors: Bruno Galy, Dunja Ferring-Appel, Christiane Becker, Norbert Gretz, Hermann-Josef Gröne, Klaus Schümann, Matthias W Hentze
PubMed ID: 23523353
Date Published: 21st Mar 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Cell Rep
Citation: Cell Rep 3(3): 844-57
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 14:38
Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
Authors: Michael Weber, Sebastian G Henkel, Sebastian Vlaic, Reinhard Guthke, Everardus J van Zoelen, Dominik Driesch
Date Published: 2013
Scales: Not specified
Abstract (Expand)
Created: 2nd Jan 2013 at 10:24  Last updated: 24th Oct 2013 at 16:15
Authors: Bruno Christ, Sandra Pelz
PubMed ID: 23184585
Date Published: 26th Nov 2012
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase HGF and Regeneration
Journal: Cytometry A
Citation: Cytometry A 83(1): 90-102
Authors: Markus Krauss, Stephan Schaller, Steffen Borchers, Rolf Findeisen, Jörg Lippert, Lars Kuepfer
DOI: 10.1371/journal.pcbi.1002750
Date Published: 25th Oct 2012
Projects: E4: Vertical integration across biological scales, E: Model integration
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 8(10) : e1002750
Scales: Cell, Liver and Organism
Abstract (Expand)
Created: 29th Oct 2012 at 12:17  Last updated: 24th Oct 2013 at 16:15
Authors: Andreas Teufel, Diana Becker, Susanne N Weber, Steven Dooley, Katja Breitkopf-Heinlein, Thorsten Maass, Katrin Hochrath, Markus Krupp, Jens U Marquardt, Martin Kolb, Bernhard Korn, Christof Niehrs, Tim Zimmermann, Patricio Godoy, Peter R Galle, Frank Lammert
PubMed ID: 22669512
Date Published: 6th Jun 2012
Projects: B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Journal of molecular medicine (Berlin, Germany)
Citation: J. Mol. Med. 90(12): 1439-47
Scales: Not specified
Abstract (Expand)
Created: 31st Jul 2012 at 11:24  Last updated: 24th Oct 2013 at 16:16
Authors: Katrin Straßburger, Marcel Tiebe, Federico Pinna, Kai Breuhahn, Aurelio A Teleman
PubMed ID: 22609549
Date Published: 16th May 2012
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga...
Journal: Dev. Biol.
Citation: Dev. Biol. 367(2): 187-96
Scales: Cell
Abstract (Expand)
Created: 16th Jan 2013 at 09:03  Last updated: 24th Oct 2013 at 16:16
Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
Authors: Dechun Feng, Xiaoni Kong, Honglei Weng, Ogyi Park, Hua Wang, Steven Dooley, M Eric Gershwin, Bin Gao
PubMed ID: 22484119
Date Published: 3rd Apr 2012
Projects: Showcase LPS and Inflammation
Journal: Gastroenterology
Citation: Gastroenterology 143(1): 188-98.e7
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 09:09  Last updated: 24th Oct 2013 at 16:16
Authors: Thomas Maiwald, Julie Blumberg, Andreas Raue, Stefan Hengl, Marcel Schilling, Sherwin Kb Sy, Verena Becker, Ursula Klingmüller, Jens Timmer
PubMed ID: 22369292
Date Published: 27th Feb 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: BMC Syst Biol
Citation: BMC Syst Biol 6: 13
Scales: Cell
Abstract:
Created: 10th Aug 2012 at 09:33  Last updated: 24th Oct 2013 at 16:16
Authors: Rebekka Schlatter, Nicole Philippi, Gaby Wangorsch, Robert Pick, Oliver Sawodny, Christoph Borner, Jens Timmer, Michael Ederer, Thomas Dandekar
PubMed ID: 22016404
Date Published: 20th Oct 2011
Projects: No Projects
Journal: Brief. Bioinformatics
Citation: Brief. Bioinformatics 13(3): 365-76
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:26
Authors: Rebekka Schlatter, Nicole Philippi, Gaby Wangorsch, Robert Pick, Oliver Sawodny, Christoph Borner, Jens Timmer, Michael Ederer, Thomas Dandekar
PubMed ID: 22016404
Date Published: 20th Oct 2011
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response, B1.1: Differential communication of wound healing and hepatoxic macropha...
Journal: Brief. Bioinformatics
Citation: Brief. Bioinformatics 13(3): 365-76
Scales: Cell
Abstract (Expand)
Created: 8th Aug 2012 at 12:07  Last updated: 24th Oct 2013 at 16:17
Authors: Christoph Kaleta, Luís F de Figueiredo, Sarah Werner, Reinhard Guthke, Michael Ristow, Stefan Schuster
PubMed ID: 21814506
Date Published: 21st Jul 2011
Scales: Not specified
Abstract (Expand)
Created: 18th Jul 2012 at 08:43  Last updated: 24th Oct 2013 at 16:18
Authors: Adrian Schröder, Johannes Wollnik, Clemens Wrzodek, Andreas Dräger, Michael Bonin, Oliver Burk, Maria Thomas, Wolfgang E Thasler, Ulrich M Zanger, Andreas Zell
PubMed ID: 21757465
Date Published: 16th Jul 2011
Projects: B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Bioinformatics
Citation: Bioinformatics 27(18): 2473-7
Scales: Not specified
Abstract (Expand)
Created: 28th Jul 2011 at 18:15  Last updated: 24th Oct 2013 at 16:18
Inferring transcriptional regulators for sets of co-expressed genes by multi-objective evolutionary optimization
Authors: Adrian Schroder, Clemens Wrzodek, Johannes Wollnik, Andreas Drager, Dierk Wanke, Kenneth W Berendzen, Andreas Zell
Date Published: 1st Jun 2011
Projects: A3.4: Linking signalling to metabolic functions
Conference: 2011 IEEE Congress of Evolutionary Computation (CEC)
Citation: Inferring transcriptional regulators for sets of co-expressed genes by multi-objective evolutionary optimization : 2285
Scales: Intercellular
Abstract (Expand)
Created: 9th Jan 2012 at 13:53  Last updated: 24th Oct 2013 at 16:18
Authors: A Raue, V Becker, U Klingmüller, J Timmer
PubMed ID: 21198117
Date Published: 5th Jan 2011
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Chaos
Citation: Chaos 20(4): 045105
Scales: Cell
Abstract (Expand)
Created: 10th Aug 2012 at 09:43  Last updated: 24th Oct 2013 at 16:19
Authors: Bruno Galy, Dunja Ferring-Appel, Sven W Sauer, Sylvia Kaden, Saïd Lyoumi, Herve Puy, Stefan Kölker, Hermann-Josef Gröne, Matthias W Hentze
PubMed ID: 20674864
Date Published: 3rd Aug 2010
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys
Journal: Cell Metab.
Citation: Cell Metab. 12(2): 194-201
Scales: Cell
Abstract (Expand)
Created: 29th Oct 2012 at 11:00  Last updated: 24th Oct 2013 at 16:20
Authors: Kristian Rother, Sabrina Hoffmann, Sascha Bulik, Andreas Hoppe, Johann Gasteiger, Herrmann-Georg Holzhütter
PubMed ID: 20513391
Date Published: 2nd Jun 2010
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Biophys. J.
Citation: Biophys. J. 98(11): 2478-86
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 10:51  Last updated: 24th Oct 2013 at 16:20
Interpretation of non-invasive breath tests using (13)C-labeled substrates--a preliminary report with (13)C-methacetin
Authors: J F Lock, P Taheri, S Bauer, H-G Holzhütter, M Malinowski, P Neuhaus, M Stockmann
PubMed ID: 20149989
Date Published: 13th Feb 2010
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Eur. J. Med. Res.
Citation: Eur. J. Med. Res. 14: 547-50
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2013 at 11:53  Last updated: 24th Oct 2013 at 16:20
Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis
Authors: Frank Götschel, Claudia Kern, Simona Lang, Titus Sparna, Cordula Markmann, Joseph Schwager, Sabine McNelly, Fritz von Weizsäcker, Stefan Laufer, Andreas Hecht, Irmgard Merfort
PubMed ID: 18261723
Date Published: 31st Dec 2007
Scales: Cell
Abstract (Expand)
Created: 30th Aug 2012 at 12:33  Last updated: 24th Oct 2013 at 16:23
Authors: Martin Golebiewski, Saqib Mir, Renate Kania, Olga Krebs, Andreas Weidemann, Ulrike Wittig, Isabel Rojas
DOI: 10.1186/1752-0509-1-S1-P4
Date Published: 2007
Scales: Not specified
Abstract:
Created: 11th Nov 2010 at 18:36  Last updated: 24th Oct 2013 at 16:23