Wordprocessing Heritability of metoprolol and torsemide pharmacokinetics

Authors: J. Matthaei, J. Brockmoller, M. V. Tzvetkov, D. Sehrt, C. Sachse-Seeboth, J. B. Hjelmborg, S. Moller, U. Halekoh, U. Hofmann, M. Schwab, R. Kerb

PubMed ID: 26344676

Date Published: 8th Sep 2015

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Clin Pharmacol Ther

Citation: Clin Pharmacol Ther. 2015 Sep 7. doi: 10.1002/cpt.258.

Scales: Not specified

Abstract (Expand)

Genetic variation in the pharmacokinetics of metoprolol and torsemide due to polymorphisms in CYP2D6, CYP2C9, and OATP1B1 has been extensively studied. However, it is still unknown how much of the ...

Created: 17th Dec 2015 at 11:46


Wordprocessing Hepatocyte fate upon TGF-β challenge is determined by the matrix environment

Authors: Christoph Meyer, Roman Liebe, Katja Breitkopf-Heinlein, Yan Liu, Alexandra Müller, Pia Rakoczy, Maria Thomas, Honglei Weng, Anastasia Bachmann, Matthias Ebert, Steven Dooley

PubMed ID: 25982745

Date Published: 20th May 2015

Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A3.3: Hepatocyte polarity

Journal: Differentiation

Citation: Differentiation :

Scales: Cell

Abstract (Expand)

Primary hepatocytes are a versatile tool to investigate all aspects of liver function, and frequently used in drug development and testing. Upon TGF-β challenge, hepatocytes either undergo an epithelial ...

Created: 17th Jun 2015 at 09:09


Wordprocessing Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression

Authors: Andreas Bitter, Andreas K Nüssler, Wolfgang E Thasler, Kathrin Klein, Ulrich M Zanger, Matthias Schwab, Oliver Burk

PubMed ID: 25634759

Date Published: 30th Jan 2015

Scales: Not specified

Abstract (Expand)

Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipogenesis, was shown to be associated with non-alcoholic fatty liver disease, which is attributed to its major isoform ...

Created: 7th Apr 2015 at 14:59


Wordprocessing How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis

Authors: Dirk Drasdo, Stefan Hoehme, Jan G. Hengstler

DOI: 10.1016/j.jhep.2014.06.013

Date Published: 1st Oct 2014

Projects: C: Liver lobule level

Journal: Journal of Hepatology

Citation: Journal of Hepatology 61(4) : 951

Scales: Not specified


Not specified

Created: 7th Nov 2014 at 15:09   Last updated: 7th Nov 2014 at 15:09


Wordprocessing Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model

Authors: Sandra Winkler, Erawan Borkham-Kamphorst, Peggy Stock, Sandra Brückner, Matthias Dollinger, Ralf Weiskirchen, Bruno Christ

PubMed ID: 24786317

Date Published: 3rd May 2014

Scales: Cell and Liver

Abstract (Expand)

Non-alcoholic steatohepatitis (NASH) is a frequent clinical picture characterised by hepatic inflammation, lipid accumulation and fibrosis. When untreated, NASH bears a high risk of developing liver ...

Created: 19th May 2014 at 20:13


Wordprocessing Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury

Authors: Peggy Stock, Sandra Brückner, Sandra Winkler, Matthias M Dollinger, Bruno Christ

PubMed ID: 24758938

Date Published: 25th Apr 2014

Scales: Liver lobule and Liver

Abstract (Expand)

Mesenchymal stem cells from human bone marrow (hMSC) have the potential to differentiate into hepatocyte-like cells in vitro and continue to maintain important hepatocyte functions in vivo after ...

Created: 19th May 2014 at 20:04


Wordprocessing How useful are clinical liver function tests in in-vitro human hepatotoxicity assays

Authors: Jürgen Borlak, Anil Chougule, Prafull Kumar Singh

PubMed ID: 24685772

Date Published: 2nd Apr 2014

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Toxicol In Vitro

Citation: Toxicol In Vitro :

Scales: Cell

Abstract (Expand)

In preclinical hepatotoxicity testing cell based assays are frequently employed. However, prediction of clinical drug induced liver injury (DILI) remains a major challenge. Here we examined the usefulness ...

Created: 4th Apr 2014 at 16:13


Wordprocessing How Does a Single Cell Know When the Liver Has Reached Its Correct Size?

Authors: Nadine Hohmann, Wei Weiwei, Uta Dahmen, Olaf Dirsch, Andreas Deutsch, Anja Voss-Böhme

DOI: 10.1371/journal.pone.0093207

Date Published: 1st Apr 2014

Projects: D4: Regeneration and Liver Size

Journal: PLoS ONE

Citation: PLoS ONE 9(4) : e93207

Scales: Intercellular, Liver lobule and Liver

Abstract (Expand)

The liver is a multi-functional organ that regulates major physiological processes and that possesses a remarkable regeneration capacity. After loss of functional liver mass the liver grows back to its ...

Created: 24th Apr 2014 at 14:21   Last updated: 24th Apr 2014 at 14:26


Wordprocessing Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Authors: Madlen Matz-Soja, Susanne Aleithe, Eugenia Marbach, Jan Böttger, Katrin Arnold, Wolfgang Schmidt-Heck, Jürgen Kratzsch, Rolf Gebhardt

PubMed ID: 24548465

Date Published: 18th Feb 2014

Projects: Virtual Liver

Journal: Cell Commun. Signal

Citation: Cell Commun. Signal 12(1): 11

Scales: Organism

Abstract (Expand)

Hedgehog signaling plays an important role in embryonic development, organogenesis and cancer. In the adult liver, Hedgehog signaling in non-parenchymal cells has been found to play a role in certain ...

Created: 11th Mar 2014 at 14:51


Wordprocessing Human parenchymal and non-parenchymal liver cell isolation, culture and characterization

Authors: Georg Damm, Elisa Pfeiffer, Britta Burkhardt, Jan Vermehren, Andreas K. Nüssler, Thomas S. Weiss

DOI: 10.1007/s12072-013-9475-7

Date Published: 1st Oct 2013

Scales: Cell


Not specified

Created: 30th Jan 2014 at 16:52   Last updated: 30th Jan 2014 at 16:54


Wordprocessing Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation

Authors: Madlen Matz-Soja, Amalya Hovhannisyan, Rolf Gebhardt

PubMed ID: 23433827

Date Published: 21st Feb 2013

Projects: Virtual Liver

Journal: Med. Hypotheses

Citation: Med. Hypotheses 80(5): 589-94

Scales: Liver

Abstract (Expand)

Metabolic Zonation, i.e. the heterogeneous distribution of different metabolic pathways in different zones of the lobules, forms the basis of proper function of the liver in metabolic homeostasis and ...

Created: 4th Feb 2014 at 08:09


Wordprocessing High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

Authors: Minjun Chen, Jürgen Borlak, Weida Tong

PubMed ID: 23258593

Date Published: 22nd Dec 2012

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Hepatology

Citation: Hepatology 58(1): 388-96

Scales: Liver

Abstract (Expand)

Drug induced liver injury (DILI) is a leading cause of drug failure in clinical trials and a major reason for drug withdrawals from the market. While there is evidence for doses of ≥ 100mg/day to be ...

Created: 28th Jan 2013 at 13:20   Last updated: 24th Oct 2013 at 16:15


Wordprocessing Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment

Authors: Lars Wiechert, Julia Németh, Tobias Pusterla, Christine Bauer, Aurora De Ponti, Sandra Manthey, Silke Marhenke, Arndt Vogel, Ursula Klingmüller, Jochen Hess, Peter Angel

PubMed ID: 23241281

Date Published: 15th Dec 2012

Projects: No Projects

Journal: Cell Commun. Signal

Citation: Cell Commun. Signal 10(1): 40

Scales: Not specified



Created: 10th Jan 2013 at 14:31   Last updated: 24th Oct 2013 at 16:15


Wordprocessing Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

Authors: René Meyer, Lorenza A D'Alessandro, Sandip Kar, Bernhard Kramer, Bin She, Daniel Kaschek, Bettina Hahn, David Wrangborg, Johan Karlsson, Mats Kvarnström, Mats Jirstrand, Wolf-Dieter Lehmann, Jens Timmer, Thomas Höfer, Ursula Klingmüller

PubMed ID: 23226133

Date Published: 28th Nov 2012

Projects: No Projects

Journal: Front Physiol

Citation: Front Physiol 3: 451

Scales: Not specified

Abstract (Expand)

In most solid cancers, cells harboring oncogenic mutations represent only a sub-fraction of the entire population. Within this sub-fraction the expression level of mutated proteins can vary significantly ...

Created: 10th Jan 2013 at 14:27   Last updated: 24th Oct 2013 at 16:15


Wordprocessing Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation

Authors: I A Hauser, S Kruck, S Gauer, A T Nies, S Winter, J Bedke, H Geiger, H Hoefeld, J Kleemann, A Asbe-Vollkopf, J Engel, O Burk, M Schwab, E Schaeffeler

PubMed ID: 22453193

Date Published: 28th Mar 2012

Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting

Journal: Clin. Pharmacol. Ther.

Citation: Clin. Pharmacol. Ther. 91(5): 905-16

Scales: Not specified

Abstract (Expand)

Delayed graft function (DGF) is an important complication in renal transplantation, contributing significantly to decrease in long-term allograft survival. In addition to donor- and recipient-related ...

Created: 18th Jul 2012 at 13:01   Last updated: 24th Oct 2013 at 16:16


Wordprocessing Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

Authors: Johannes G Bode, Ute Albrecht, Dieter Häussinger, Peter C Heinrich, Fred Schaper

PubMed ID: 22093287

Date Published: 16th Nov 2011

Scales: Cell and Liver

Abstract (Expand)

The function of the liver as an important constituent of the immune system involved in innate as well as adaptive immunity is warranted by different highly specialized cell populations. As the major ...

Created: 31st Aug 2012 at 11:44   Last updated: 24th Oct 2013 at 16:17


Wordprocessing HMMerThread: detecting remote, functional conserved domains in entire genomes by combining relaxed sequence-database searches with fold recognition

Authors: Charles Richard Bradshaw, Vineeth Surendranath, Robert Henschel, Matthias Stefan Mueller, Bianca Hermine Habermann

PubMed ID: 21423752

Date Published: 16th Nov 2010

Scales: Not specified

Abstract (Expand)

Conserved domains in proteins are one of the major sources of functional information for experimental design and genome-level annotation. Though search tools for conserved domain databases such as ...

Created: 24th Jun 2011 at 16:19   Last updated: 24th Oct 2013 at 16:19


Wordprocessing HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

Authors: Christoph Gille, Christian Bölling, Andreas Hoppe, Sascha Bulik, Sabrina Hoffmann, Katrin Hübner, Anja Karlstädt, Ramanan Ganeshan, Matthias König, Kristian Rother, Michael Weidlich, Jörn Behre, Herrmann-Georg Holzhütter

PubMed ID: 20823849

Date Published: 30th Dec 2009

Scales: Liver

Abstract (Expand)

We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions. The network ...

Created: 9th Dec 2010 at 13:39   Last updated: 24th Oct 2013 at 16:20


Wordprocessing Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue

Authors: Sebastian Zellmer, Stephan Sickinger, Wolfgang Schmidt-Heck, Reinhard Guthke, Rolf Gebhardt

PubMed ID: 19470084

Date Published: 14th May 2009

Projects: No Projects

Journal: J. Anat.

Citation: J. Anat. 215(2): 176-83

Scales: Not specified

Abstract (Expand)

Suppressor of cytokine signalling 2 (SOCS-2), a dual effector of growth hormone signalling, was found to be heterogeneously expressed in murine liver parenchyma. Data from Affymetrix gene arrays, ...

Created: 28th Sep 2010 at 09:25   Last updated: 24th Oct 2013 at 16:21


Wordprocessing Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

Authors: Steven Dooley, Jafar Hamzavi, Loredana Ciuclan, Patricio Godoy, Iryna Ilkavets, Sabrina Ehnert, Elke Ueberham, Rolf Gebhardt, Stephan Kanzler, Andreas Geier, Katja Breitkopf, Honglei Weng, Peter R Mertens

PubMed ID: 18602923

Date Published: 15th May 2008

Projects: A3.3: Hepatocyte polarity, HepatoSys

Journal: Gastroenterology

Citation: Gastroenterology 135(2): 642-59

Scales: Not specified

Abstract (Expand)

The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute ...

Created: 24th Feb 2012 at 17:08   Last updated: 24th Oct 2013 at 16:22

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