Publications

 

Wordprocessing Establishment of a rat model: Associating liver partition with portal vein ligation for staged hepatectomy


Authors: Weiwei Wei, Tianjiao Zhang, Sara Zafarnia, Andrea Schenk, Chichi Xie, Chunyi Kan, Olaf Dirsch, Utz Settmacher, Uta Dahmen

DOI: 10.1016/j.surg.2015.12.005

Date Published: 1st May 2016

Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale

Journal: Surgery

Citation: Surgery 159(5) : 1299

Scales: Liver

Abstract (Expand)

BACKGROUND: We adapted the anatomically oriented parenchyma-preserving resection technique for associating liver partition with portal vein ligation (PVL) for staged hepatectomy (ALPPS) in rats and ...

Created: 26th May 2017 at 10:46   Last updated: 26th May 2017 at 10:47


 

Wordprocessing Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles


Authors: J. Zhang, U. Doshi, A. Suzuki, C. W. Chang, J. Borlak, A. P. Li, W. Tong

PubMed ID: 26581450

Date Published: 20th Nov 2015

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Journal: Chem Biol Interact

Citation: Chem Biol Interact. 2015 Nov 12. pii: S0009-2797(15)30110-1. doi: 10.1016/j.cbi.2015.11.008.

Scales: Cell

Abstract (Expand)

We report here the results of a collaborative research program to develop a robust and reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) potential of new ...

Created: 30th Dec 2015 at 10:41


 

Wordprocessing Evolutionary game theory: cells as players


Authors: Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter, Stefan Schuster

PubMed ID: 25270362

Date Published: 2nd Oct 2014

Projects: No Projects

Journal: Mol Biosyst

Citation: Mol Biosyst 10(12): 3044-65

Scales: Not specified

Abstract (Expand)

In two papers we review game theory applications in biology below the level of cognitive living beings. It can be seen that evolution and natural selection replace the rationality of the actors ...

Created: 3rd Dec 2014 at 20:25


 

Wordprocessing Evolutionary game theory: molecules as players


Authors: Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen, Anja Schroeter

PubMed ID: 25248454

Date Published: 25th Sep 2014

Projects: No Projects

Journal: Mol Biosyst

Citation: Mol Biosyst 10(12): 3066-74

Scales: Not specified

Abstract (Expand)

In this and an accompanying paper we review the use of game theoretical concepts in cell biology and molecular biology. This review focuses on the subcellular level by considering viruses, genes, and ...

Created: 3rd Dec 2014 at 20:29


 

Wordprocessing Explanted diseased livers - a possible source of metabolic competent primary human hepatocytes


Authors: Moritz Kleine, Marc Riemer, Till Krech, Daphne DeTemple, Mark D Jäger, Frank Lehner, Michael P Manns, Jürgen Klempnauer, Jürgen Borlak, Hueseyin Bektas, Florian W R Vondran

PubMed ID: 24999631

Date Published: 7th Jul 2014

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: PLoS ONE

Citation: PLoS ONE 9(7): e101386

Scales: Cell

Abstract (Expand)

Being an integral part of basic, translational and clinical research, the demand for primary human hepatocytes (PHH) is continuously growing while the availability of tissue resection material for the ...

Created: 10th Jul 2014 at 12:09


 

Wordprocessing Estimating Dose Painting Effects in Radiotherapy: A Mathematical Model


Authors: Juan Carlos López Alfonso, Nick Jagiella, Luis Núñez, Miguel A. Herrero, Dirk Drasdo

DOI: 10.1371/journal.pone.0089380

Date Published: 26th Feb 2014

Projects: No Projects

Journal: PLoS ONE

Citation: PLoS ONE 9(2) : e89380

Scales: Not specified

Abstract:

Not specified

Created: 7th Nov 2014 at 15:14   Last updated: 7th Nov 2014 at 15:14


 

Wordprocessing Enabling multiscale modeling in systems medicine


Authors: Olaf Wolkenhauer, Charles Auffray, Olivier Brass, Jean Clairambault, Andreas Deutsch, Dirk Drasdo, Francesco Gervasio, Luigi Preziosi, Philip Maini, Anna Marciniak-Czochra, Christina Kossow, Lars Kuepfer, Katja Rateitschak, Ignacio Ramis-Conde, Benjamin Ribba, Andreas Schuppert, Rod Smallwood, Georgios Stamatakos, Felix Winter, Helen Byrne

DOI: 10.1186/gm538

Date Published: 2014

Projects: No Projects

Journal: Genome Med

Citation: Genome Med 6(3) : 21

Scales: Not specified

Abstract:

Not specified

Created: 7th Nov 2014 at 15:10   Last updated: 7th Nov 2014 at 15:10


 

Wordprocessing Evaluation of 41 candidate gene variants for obesity in the EPIC-potsdam cohort by multi-locus stepwise regression


Authors: Sven Knüppel, Klaus Rohde, Karina Meidtner, Dagmar Drogan, Hermann-Georg Holzhütter, Heiner Boeing, Eva Fisher

PubMed ID: 23874820

Date Published: 12th Jul 2013

Projects: No Projects

Journal: PLoS ONE

Citation: PLoS ONE 8(7): e68941

Scales: Not specified

Abstract (Expand)

Obesity has become a leading preventable cause of morbidity and mortality in many parts of the world. It is thought to originate from multiple genetic and environmental determinants. The aim of the ...

Created: 20th Jan 2014 at 10:28


 

Wordprocessing Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression


Authors: Jessica K Rieger, Kathrin Klein, Stefan Winter, Ulrich M Zanger

PubMed ID: 23733276

Date Published: 3rd Jun 2013

Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Journal: Drug Metab. Dispos.

Citation: Drug Metab. Dispos. 41(10): 1752-62

Scales: Not specified

Abstract (Expand)

Genes that are important for the detoxification of drugs and other xenobiotics show a high degree of interindividual variation attributable to regulation by diverse genetic, nongenetic, and epigenetic ...

Created: 8th Jan 2014 at 14:05


 

Wordprocessing Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists


Authors: L. Shi, L. Jong, U. Wittig, P. Lucarelli, M. Stepath, S. Mueller, L. A. D'Alessandro, U. Klingmuller, W. Muller

PubMed ID: 23549603

Date Published: 3rd Apr 2013

Projects: F1: The data management system

Journal: J Integr Bioinform

Citation: J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.

Scales: Not specified

Abstract (Expand)

In systems biology, quantitative experimental data is the basis of building mathematical models. In most of the cases, they are stored in Excel files and hosted locally. To have a public database for ...

Created: 7th Aug 2015 at 12:16


 

Wordprocessing Experimental design for parameter estimation of gene regulatory networks


Authors: Bernhard Steiert, Andreas Raue, Jens Timmer, Clemens Kreutz

PubMed ID: 22815723

Date Published: 16th Jul 2012

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Journal: PLoS ONE

Citation: PLoS ONE 7(7): e40052

Scales: Cell

Abstract (Expand)

Systems biology aims for building quantitative models to address unresolved issues in molecular biology. In order to describe the behavior of biological cells adequately, gene regulatory networks (GRNs) ...

Created: 8th Aug 2012 at 11:44   Last updated: 24th Oct 2013 at 16:16


 

Wordprocessing Enzymatic features of the glucose metabolism in tumor cells


Authors: Anique Herling, Matthias König, Sascha Bulik, Hermann-Georg Holzhütter

PubMed ID: 21564549

Date Published: 10th Jun 2011

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: FEBS J.

Citation: FEBS J. 278(14): 2436-59

Scales: Not specified

Abstract (Expand)

Many tumor types exhibit an impaired Pasteur effect, i.e. despite the presence of oxygen, glucose is consumed at an extraordinarily high rate compared with the tissue from which they originate - the ...

Created: 4th Jan 2013 at 11:02   Last updated: 24th Oct 2013 at 16:18


 

Wordprocessing Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes


Authors: Andreas Hoppe, Christine Richter, Hermann-Georg Holzhütter

PubMed ID: 21664944

Date Published: 2nd Jun 2011

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Journal: BioSystems

Citation: BioSystems 105(2): 122-9

Scales: Cell

Abstract:

Not specified

Created: 23rd Oct 2012 at 12:32   Last updated: 24th Oct 2013 at 16:18


 

Wordprocessing Enzyme kinetics informatics: from instrument to browser


Authors: Neil Swainston, Martin Golebiewski, Hanan L Messiha, Naglis Malys, Renate Kania, Sylvestre Kengne, Olga Krebs, Saqib Mir, Heidrun Sauer-Danzwith, Kieran Smallbone, Andreas Weidemann, Ulrike Wittig, Douglas B Kell, Pedro Mendes, Wolfgang Müller, Norman W Paton, Isabel Rojas

PubMed ID: 20738395

Date Published: 3rd Aug 2010

Projects: F3: Kinetic data handling

Journal: FEBS J.

Citation: FEBS J. 277(18): 3769-79

Scales: Not specified

Abstract (Expand)

A limited number of publicly available resources provide access to enzyme kinetic parameters. These have been compiled through manual data mining of published papers, not from the original, raw ...

Created: 11th Jan 2011 at 11:11   Last updated: 24th Oct 2013 at 16:20


 

Wordprocessing Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver


Authors: Anne T. Nies, Hermann Koepsell, Stefan Winter, Oliver Burk, Kathrin Klein, Reinhold Kerb, Ulrich M. Zanger, Dietrich Keppler, Matthias Schwab, Elke Schaeffeler

DOI: 10.1002/hep.23103

Date Published: 1st Oct 2009

Projects: A3.4: Linking signalling to metabolic functions

Journal: Hepatology

Citation: Hepatology 50(4) : 1227

Scales: Intercellular

Abstract:

Not specified

Created: 3rd Aug 2012 at 08:37   Last updated: 24th Oct 2013 at 16:21


 

Wordprocessing Estimation of gene induction enables a relevance-based ranking of gene sets


Authors: Kilian Bartholomé, Clemens Kreutz, Jens Timmer

PubMed ID: 19580524

Date Published: 8th Jul 2009

Projects: HepatoSys

Journal: J. Comput. Biol.

Citation: J. Comput. Biol. 16(7): 959-67

Scales: Cell

Abstract (Expand)

In order to handle and interpret the vast amounts of data produced by microarray experiments, the analysis of sets of genes with a common biological functionality has been shown to be advantageous ...

Created: 10th Aug 2012 at 11:44   Last updated: 24th Oct 2013 at 16:21


 

Wordprocessing Erythropoietin-receptor gene regulation in neuronal cells


Authors: Iwona Wallach, Juan Zhang, Anika Hartmann, Frank K H van Landeghem, Anna Ivanova, Martin Klar, Christof Dame

PubMed ID: 19218878

Date Published: 17th Feb 2009

Projects: No Projects

Journal: Pediatr. Res.

Citation: Pediatr. Res. 65(6): 619-24

Scales: Not specified

Abstract (Expand)

Because erythropoietin (Epo) is intensively studied as neuroprotective agent, Epo receptor (EpoR) regulation in neurons is of particular interest. Herein, we investigated molecular mechanisms of EpoR ...

Created: 4th Jan 2013 at 11:24   Last updated: 24th Oct 2013 at 16:21


 

Wordprocessing Effects of sequestration on signal transduction cascades


Authors: Nils Blüthgen, Frank J Bruggeman, Stefan Legewie, Hanspeter Herzel, Hans V Westerhoff, Boris N Kholodenko

PubMed ID: 16478465

Date Published: 16th Feb 2006

Projects: HepatoSys

Journal: FEBS J.

Citation: FEBS J. 273(5): 895-906

Scales: Not specified

Abstract (Expand)

The building blocks of most signal transduction pathways are pairs of enzymes, such as kinases and phosphatases, that control the activity of protein targets by covalent modification. It has previously ...

Created: 11th Sep 2012 at 13:10   Last updated: 24th Oct 2013 at 16:24



Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network

(v.0.22.0)

Related Projects and friends


Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:

Ror-logo-32

Icons:
Silk icons 1.3
Crystal Clear icons