Publications
Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling
Authors: Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F. Templin, Thomas O. Joos, Wolfgang E. Thasler, Andreas Zell, Ulrich M. Zanger
DOI: 10.1371/journal.pcbi.1004431
Date Published: 4th Jan 2016
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 12(1) : e1004431
Scales: Cell
Abstract (Expand)
Created: 7th Jan 2016 at 15:20  Last updated: 7th Jan 2016 at 15:24
Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Authors: H. Stark, M. Fichtner, R. Konig, S. Lorkowski, S. Schuster
PubMed ID: 26382968
Date Published: 14th Sep 2015
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Biochimie
Citation: Biochimie. 2015 Nov;118:185-94. doi: 10.1016/j.biochi.2015.09.017. Epub 2015 Sep 14.
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: CYP Expression and Induction by Nuclear Receptor Agonists
Authors: A. Braeuning, M. Thomas, U. Hofmann, S. Vetter, E. Zeller, B. Petzuch, J. Johanning, W. Schroth, T. S. Weiss, U. M. Zanger, M. Schwarz
PubMed ID: 26310804
Date Published: 28th Aug 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Drug Metab Dispos
Citation: Drug Metab Dispos. 2015 Aug 26. pii: dmd.115.064667.
Authors: Nadinath B. Nillegoda, Janine Kirstein, Anna Szlachcic, Mykhaylo Berynskyy, Antonia Stank, Florian Stengel, Kristin Arnsburg, Xuechao Gao, Annika Scior, Ruedi Aebersold, D. Lys Guilbride, Rebecca C. Wade, Richard I. Morimoto, Matthias P. Mayer, Bernd Bukau
DOI: 10.1038/nature14884
Date Published: 5th Aug 2015
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Nature
Citation: Nature 524(7564) : 247
Scales: Organism
Abstract (Expand)
Created: 18th Sep 2015 at 13:35  Last updated: 18th Sep 2015 at 13:41
Authors: Julia Romanowska, Daria B. Kokh, Jonathan C. Fuller, Rebecca C. Wade
DOI: 10.1002/9783527673025.ch11
Date Published: 11th May 2015
Projects: F3: Kinetic data handling
Book: Thermodynamics and Kinetics of Drug Binding
Citation: Methods and Principles in Medicinal Chemistry : 211
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 13:23  Last updated: 18th Sep 2015 at 13:26
Authors: Sylvie Schulze, Sebastian G. Henkel, Dominik Driesch, Reinhard Guthke, Jörg Linde
Date Published: 6th Feb 2015
Scales: Cell and Intercellular
Abstract:
Created: 11th Feb 2015 at 08:18  Last updated: 11th Feb 2015 at 08:24
Authors: Frank T Bergmann, Richard Adams, Stuart Moodie, Jonathan Cooper, Mihai Glont, Martin Golebiewski, Michael Hucka, Camille Laibe, Andrew K Miller, David P Nickerson, Brett G Olivier, Nicolas Rodriguez, Herbert M Sauro, Martin Scharm, Stian Soiland-Reyes, Dagmar Waltemath, Florent Yvon, Nicolas Le Novère
PubMed ID: 25494900
Date Published: 14th Dec 2014
Projects: F1: The data management system
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 15(1): 369
Scales: Not specified
Abstract (Expand)
Created: 9th Jan 2015 at 15:06
Authors: Christian Tönsing, Jens Timmer, Clemens Kreutz
PubMed ID: 25215847
Date Published: 11th Aug 2014
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Phys Rev E Stat Nonlin Soft Matter Phys
Citation: Phys Rev E Stat Nonlin Soft Matter Phys 90(2): 023303
Authors: L Kuepfer, R Kerb, A M Henney
DOI: 10.1038/psp.2014.25
Date Published: 30th Jul 2014
Projects: G: Clinical translation
Journal: CPT: pharmacomet. syst. pharmacol.
Citation: CPT: pharmacomet. syst. pharmacol. 3(7) : e127
Scales: Organism
Abstract:
Created: 13th Aug 2014 at 19:07  Last updated: 13th Aug 2014 at 19:12
Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling
Authors: Kristin Dickschen, Thomas Eissing, Thomas Mürdter, Matthias Schwab, Stefan Willmann, Georg Hempel
PubMed ID: 24936398
Date Published: 5th Jun 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Springerplus
Citation: Springerplus 3: 285
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:48
Authors: Ulrike Wittig, Maja Rey, Renate Kania, Meik Bittkowski, Lei Shi, Martin Golebiewski, Andreas Weidemann, Wolfgang Müller, Isabel Rojas
PubMed ID: 24165050
Date Published: 30th Oct 2013
Scales: Not specified
Abstract (Expand)
Created: 27th Nov 2013 at 13:21
Comparative analysis of TGF-beta/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines
Authors: J. Dzieran, J. Fabian, T. Feng, C. Coulouarn, I. Ilkavets, A. Kyselova, K. Breuhahn, S. Dooley, N. M. Meindl-Beinker
PubMed ID: 23991075
Date Published: 22nd Aug 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS One
Citation: PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252. eCollection 2013.
Scales: Not specified
Abstract (Expand)
Created: 27th Jul 2015 at 07:19
Authors: Sabrina Krautbauer, Josef Wanninger, Kristina Eisinger, Yvonne Hader, Michael Beck, Andrea Kopp, Andreas Schmid, Thomas S Weiss, Christoph Dorn, Christa Buechler
PubMed ID: 23906870
Date Published: 29th Jul 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.6: Transcription factor network and links to metabolism in NAFLD, CTU SOP Human Hepatocytes, Show cases
Journal: Exp. Mol. Pathol.
Citation: Exp. Mol. Pathol. 95(2): 199-205
Authors: C Meyer, Y Liu, A Kaul, I Peipe, S Dooley
PubMed ID: 23328673
Date Published: 19th Jan 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.3: Hepatocyte polarity
Journal: Cell Death Dis
Citation: Cell Death Dis 4: e466
Scales: Cell
Abstract (Expand)
Created: 23rd Jan 2013 at 17:53  Last updated: 24th Oct 2013 at 16:15
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Authors: Ulrich M Zanger, Matthias Schwab
PubMed ID: 23333322
Date Published: 16th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Pharmacol. Ther.
Citation: Pharmacol. Ther. 138(1): 103-41
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:40
Authors: Bettina Hahn, Lorenza Alice D Alessandro, Sofia Depner, Katharina Waldow, Martin Erich Boehm, Julie Bachmann, Marcel Schilling, Ursula Klingmüller, Wolf Dieter Lehmann
PubMed ID: 23210697
Date Published: 6th Dec 2012
Projects: No Projects
Journal: J. Proteome Res.
Citation: J. Proteome Res. 12(2): 637-46
Scales: Not specified
Abstract (Expand)
Created: 10th Jan 2013 at 14:19  Last updated: 24th Oct 2013 at 16:15
Authors: M Schelker, A Raue, J Timmer, C Kreutz
PubMed ID: 22962477
Date Published: 11th Sep 2012
Projects: A2: Integration of Signalling Pathways in Hepatocellular Response
Journal: Bioinformatics
Citation: Bioinformatics 28(18): i529-i534
Scales: Cell
Abstract (Expand)
Created: 29th Oct 2012 at 10:19  Last updated: 24th Oct 2013 at 16:15
Authors: Anja Karlstaedt, Daniela Fliegner, Georgios Kararigas, Hugo S Ruderisch, Vera Regitz-Zagrosek, Hermann G Holzhütter
PubMed ID: 22929619
Date Published: 29th Aug 2012
Projects: No Projects
Journal: BMC Syst Biol
Citation: BMC Syst Biol 6: 114
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 12:48  Last updated: 24th Oct 2013 at 16:16
Central energy metabolism remains robust in acute steatotic hepatocytes challenged by a high free fatty acid load
Authors: Jens Niklas, Anne Bonin, Stefanie Mangin, Joachim Bucher, Stephanie Kopacz, Madlen Matz-Soja, Carlo Thiel, Rolf Gebhardt, Ute Hofmann, Klaus Mauch
PubMed ID: 22831974
Date Published: 27th Jul 2012
Projects: A1: Cellular metabolism, A: Cellular level
Journal: BMB Rep
Citation: BMB Rep 45(7): 396-401
Scales: Not specified
Abstract (Expand)
Created: 14th Aug 2012 at 14:54  Last updated: 24th Oct 2013 at 16:16
Authors: Matthias König, Andreas Dräger, Hermann-Georg Holzhütter
PubMed ID: 22772946
Date Published: 10th Jul 2012
Projects: A1: Cellular metabolism, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, F: Data management
Journal: Bioinformatics (Oxford, England)
Citation: Bioinformatics 28(18): 2402-3
Scales: Not specified
Abstract (Expand)
Created: 12th Jul 2012 at 08:37  Last updated: 24th Oct 2013 at 16:16
Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia
Authors: Evgeny A Moskalev, Katrin Luckert, Ivan A Vorobjev, Sergey E Mastitsky, Aleena A Gladkikh, Achim Stephan, Marita Schrenk, Kamil D Kaplanov, Olga B Kalashnikova, Oliver Pötz, Thomas O Joos, Jörg D Hoheisel
PubMed ID: 22672427
Date Published: 6th Jun 2012
Projects: No Projects
Journal: BMC Cancer
Citation: BMC Cancer 12: 213
Scales: Not specified
Abstract:
Created: 27th Nov 2012 at 13:25  Last updated: 24th Oct 2013 at 16:16
Authors: J. D. Stewart, R. Marchan, M. S. Lesjak, J. Lambert, R. Hergenroeder, J. K. Ellis, C.-H. Lau, H. C. Keun, G. Schmitz, J. Schiller, M. Eibisch, C. Hedberg, H. Waldmann, E. Lausch, B. Tanner, J. Sehouli, J. Sagemueller, H. Staude, E. Steiner, J. G. Hengstler
Date Published: 22nd May 2012
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Proceedings of the National Academy of Sciences
Citation: Proceedings of the National Academy of Sciences 109(21) : 8155
Scales: Not specified
Abstract:
Created: 29th Oct 2012 at 12:28  Last updated: 24th Oct 2013 at 16:16
Authors: Heiko Stark, Stefan Schuster
PubMed ID: 22604890
Date Published: 19th May 2012
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver
Journal: Journal of applied physiology (Bethesda, Md. : 1985)
Citation: J. Appl. Physiol. 113(3): 355-67
Scales: Liver
Abstract (Expand)
Created: 1st Aug 2012 at 11:57  Last updated: 24th Oct 2013 at 16:16
Authors: Tim Rocktäschel, Michael Weidlich, Ulf Leser
PubMed ID: 22500000
Date Published: 12th Apr 2012
Projects: F2: The Liver Knowledge Base (LKB), F: Data management
Journal: Bioinformatics
Citation: Bioinformatics 28(12): 1633-40
Scales: Not specified
Abstract (Expand)
Created: 11th Jul 2012 at 08:21  Last updated: 24th Oct 2013 at 16:16
Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes
Authors: Karine Sá Ferreira, Clemens Kreutz, Sabine Macnelly, Karin Neubert, Angelika Haber, Matthew Bogyo, Jens Timmer, Christoph Borner
PubMed ID: 22246639
Date Published: 17th Jan 2012
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: Apoptosis : an international journal on programmed cell death
Citation: Apoptosis 17(5): 503-15
Scales: Not specified
Abstract (Expand)
Created: 20th Mar 2012 at 21:32  Last updated: 24th Oct 2013 at 16:17
Authors: Mélanie Courtot, Nick Juty, Christian Knüpfer, Dagmar Waltemath, Anna Zhukova, Andreas Dräger, Michel Dumontier, Andrew Finney, Martin Golebiewski, Janna Hastings, Stefan Hoops, Sarah Keating, Douglas B Kell, Samuel Kerrien, James Lawson, Allyson Lister, James Lu, Rainer Machne, Pedro Mendes, Matthew Pocock, Nicolas Rodriguez, Alice Villeger, Darren J Wilkinson, Sarala Wimalaratne, Camille Laibe, Michael Hucka, Nicolas Le Novère
PubMed ID: 22027554
Date Published: 27th Oct 2011
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, F1: The data management system, F3: Kinetic data handling, Showcase Steatosis
Journal: Mol. Syst. Biol.
Citation: Mol. Syst. Biol. 7: 543
Scales: Cell, Intercellular, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 27th Oct 2011 at 15:09  Last updated: 24th Oct 2013 at 16:17
Authors: A M M Kober, S Legewie, C Pforr, N Fricker, R Eils, P H Krammer, I N Lavrik
PubMed ID: 21975294
Date Published: 7th Oct 2011
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: Cell Death Dis
Citation: Cell Death Dis 2: e212
Scales: Cell
Abstract (Expand)
Created: 3rd Sep 2012 at 11:25  Last updated: 24th Oct 2013 at 16:17
Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies
Authors: Maria Stella Ritorto, Jürgen Borlak
PubMed ID: 21644509
Date Published: 6th Jun 2011
Authors: Andreas K Nussler, Katrin Zeilinger, Lilianna Schyschka, Sabrina Ehnert, Jörg C Gerlach, Xueying Yan, Serene M L Lee, Maren Ilowski, Wolfgang E Thasler, Thomas S Weiss
PubMed ID: 21461918
Date Published: 3rd Apr 2011
Projects: CTU SOP Human Hepatocytes, HepatoSys
Journal: J Mater Sci Mater Med
Citation: J Mater Sci Mater Med 22(5): 1087-99
Authors: Regina Samaga, Axel Von Kamp, Steffen Klamt
PubMed ID: 20078396
Date Published: 19th Jan 2010
Projects: No Projects
Journal: J. Comput. Biol.
Citation: J. Comput. Biol. 17(1): 39-53
Scales: Not specified
Abstract (Expand)
Created: 14th Aug 2012 at 10:31  Last updated: 24th Oct 2013 at 16:20
Authors: Matthias Stein, Razif R Gabdoulline, Rebecca C Wade
PubMed ID: 20024078
Date Published: 16th Dec 2009
Projects: F3: Kinetic data handling, HepatoSys
Journal: Mol Biosyst
Citation: Mol Biosyst 6(1): 152-64
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 14:08  Last updated: 24th Oct 2013 at 16:21
Authors: Katrin Hübner, Thomas Schwager, Karl Winkler, Jens-Georg Reich, Hermann-Georg Holzhütter
PubMed ID: 18497853
Date Published: 24th May 2008
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: PLoS Comput. Biol.
Citation: PLoS Comput. Biol. 4(5): e1000079
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 12:57  Last updated: 24th Oct 2013 at 16:22
Authors: Mark M Schatz, Björn Peters, Nadja Akkad, Nina Ullrich, Alejandra Nacarino Martinez, Oliver Carroll, Sascha Bulik, Hans-Georg Rammensee, Peter van Endert, Hermann-Georg Holzhütter, Stefan Tenzer, Hansjörg Schild
PubMed ID: 18292545
Date Published: 23rd Feb 2008
Projects: No Projects
Journal: J. Immunol.
Citation: J. Immunol. 180(5): 3210-7
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 11:07  Last updated: 24th Oct 2013 at 16:22
Authors: Matthias Stein, Razif R Gabdoulline, Rebecca C Wade
PubMed ID: 18208384
Date Published: 23rd Jan 2008
Scales: Cell
Abstract (Expand)
Created: 31st Oct 2012 at 14:12  Last updated: 24th Oct 2013 at 16:23
Authors: Benjamin Sefa Menküc, Christoph Gille, Hermann-Georg Holzhütter
PubMed ID: 19425141
Date Published: 2008
Projects: No Projects
Journal: Genome Inform
Citation: Genome Inform 20: 270-6
Scales: Not specified
Abstract (Expand)
Created: 4th Jan 2013 at 13:01  Last updated: 24th Oct 2013 at 16:23
Authors: Stefan Legewie, Birgit Schoeberl, Nils Blüthgen, Hanspeter Herzel
PubMed ID: 17526574
Date Published: 25th May 2007
Scales: Not specified
Abstract (Expand)
Created: 11th Sep 2012 at 13:07  Last updated: 24th Oct 2013 at 16:23
Authors: Sanja Tomić, Branimir Bertosa, Ting Wang, Rebecca C Wade
PubMed ID: 17295314
Date Published: 14th Feb 2007
Scales: Not specified
Abstract (Expand)
Created: 31st Oct 2012 at 14:17  Last updated: 24th Oct 2013 at 16:23
Authors: Stefan Hoops, Sven Sahle, Ralph Gauges, Christine Lee, Jürgen Pahle, Natalia Simus, Mudita Singhal, Liang Xu, Pedro Mendes, Ursula Kummer
PubMed ID: 17032683
Date Published: 10th Oct 2006
Scales: Not specified
Abstract (Expand)
Created: 11th Sep 2012 at 13:26  Last updated: 24th Oct 2013 at 16:24
Computational processing and error reduction strategies for standardized quantitative data in biological networks
Authors: Marcel Schilling, Thomas Maiwald, Sebastian Bohl, Markus Kollmann, Clemens Kreutz, Jens Timmer, Ursula Klingmüller
PubMed ID: 16336276
Date Published: 13th Dec 2005
Scales: Not specified
Abstract (Expand)
Created: 23rd Aug 2012 at 13:22  Last updated: 24th Oct 2013 at 16:24