Wordprocessing Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

Authors: Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha, Julio Saez-Rodriguez

PubMed ID: 23525368

Date Published: 26th Mar 2013

Scales: Cell, Liver and Organism

Abstract (Expand)

Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the ...

Created: 3rd Jun 2013 at 16:37   Last updated: 24th Oct 2013 at 16:14


Wordprocessing Biggest challenges in bioinformatics

Authors: Jonathan C Fuller, Pierre Khoueiry, Holger Dinkel, Kristoffer Forslund, Alexandros Stamatakis, Joseph Barry, Aidan Budd, Theodoros G Soldatos, Katja Linssen, Abdul Mateen Rajput

DOI: 10.1038/embor.2013.34

Date Published: 15th Mar 2013

Projects: F: Data management

Journal: EMBO Rep

Citation: EMBO Rep 14(4) : 302

Scales: Not specified

Abstract (Expand)

The third Heidelberg Unseminars in Bioinformatics (HUB) was held on 18th October 2012, at Heidelberg University, Germany. HUB brought together around 40 bioinformaticians from academia and industry to ...

Created: 13th Jan 2014 at 15:08   Last updated: 13th Jan 2014 at 15:14


Wordprocessing Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells

Authors: Qi Li, Xing Gu, Honglei Weng, Shahrouz Ghafoory, Yan Liu, Teng Feng, Johanna Dzieran, Li Li, Iryna Ilkavets, Marianna Kruithof-de Julio, Stefan Munker, Alexander Marx, Albrecht Piiper, Eduardo Augusto Alonso, Norbert Gretz, Chunfang Gao, Stefan Wölfl, Steven Dooley, Katja Breitkopf-Heinlein

PubMed ID: 23281849

Date Published: 4th Jan 2013

Scales: Cell

Abstract (Expand)

80 - 90% of primary liver cancer cases originate from hepatocellular carcinoma (HCC), which has been regarded as the fifth most common cancer and the third most fatal reason responsible for cancer-related ...

Created: 18th Jan 2013 at 10:41   Last updated: 24th Oct 2013 at 16:15


Wordprocessing Biochemical network-based drug-target prediction

Authors: Edda Klipp, Rebecca C Wade, Ursula Kummer

PubMed ID: 20554441

Date Published: 14th Jun 2010

Projects: HepatoSys

Journal: Curr. Opin. Biotechnol.

Citation: Curr. Opin. Biotechnol. 21(4): 511-6

Scales: Not specified

Abstract (Expand)

The use of networks to aid the drug discovery process is a rather new but booming endeavor. A vast variety of different types of networks are being constructed and analyzed for various different tasks ...

Created: 30th Aug 2012 at 13:17   Last updated: 24th Oct 2013 at 16:20


Wordprocessing BowTieBuilder: modeling signal transduction pathways

Authors: Jochen Supper, Lucía Spangenberg, Hannes Planatscher, Andreas Dräger, Adrian Schröder, Andreas Zell

DOI: 10.1186/1752-0509-3-67

Date Published: 2009

Scales: Not specified

Abstract (Expand)

Background Sensory proteins react to changing environmental conditions by transducing signals into the cell. These signals are integrated into core proteins that activate downstream target proteins ...

Created: 27th Jan 2011 at 14:51   Last updated: 24th Oct 2013 at 16:22


Wordprocessing Bridging from molecular simulation to biochemical networks

Authors: Matthias Stein, Razif R Gabdoulline, Rebecca C Wade

PubMed ID: 17395455

Date Published: 28th Mar 2007

Projects: HepatoSys

Journal: Curr. Opin. Struct. Biol.

Citation: Curr. Opin. Struct. Biol. 17(2): 166-72

Scales: Not specified

Abstract (Expand)

How can we make the connection between the three-dimensional structures of individual proteins and understanding how complex biological systems involving many proteins work? The modelling and simulation ...

Created: 31st Oct 2012 at 14:15   Last updated: 24th Oct 2013 at 16:23

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