Systems analysis of iron metabolism: the network of iron pools and fluxes


Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation in different cell types is intertwined with a global hormonal signalling structure. Iron deficiency as well as excess of iron are frequent and serious human disorders. They can affect every cell, but also the organism as a whole.


Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

BMC Syst Biol
BMC Syst Biol 4: 112
13th Aug 2010

Tiago J S Lopes, Tatyana Luganskaja, Maja Vujić Spasić, Matthias W Hentze, Martina U Muckenthaler, Klaus Schümann, Jens G Reich

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[Matthias Hentze] [Martina Muckenthaler]

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Views: 3229
  • Created: 19th Jul 2012 at 11:25
  • Last updated: 24th Oct 2013 at 16:19

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