Wordprocessing

In silico evidence for gluconeogenesis from fatty acids in humans

Abstract:

The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is "No". Using recent advances in Systems Biology in the form of large-scale metabolic reconstructions, we reassessed this question by performing a global investigation of a genome-scale human metabolic network, which had been reconstructed on the basis of experimental results. By elementary flux pattern analysis, we found numerous pathways on which gluconeogenesis from fatty acids is feasible in humans. On these pathways, four moles of acetyl-CoA are converted into one mole of glucose and two moles of CO₂. Analyzing the detected pathways in detail we found that their energetic requirements potentially limit their capacity. This study has many other biochemical implications: effect of starvation, sports physiology, practically carbohydrate-free diets of inuit, as well as survival of hibernating animals and embryos of egg-laying animals. Moreover, the energetic loss associated to the usage of gluconeogenesis from fatty acids can help explain the efficiency of carbohydrate reduced and ketogenic diets such as the Atkins diet.

21814506

Projects: HepatoSys

PLoS Comput. Biol.
PLoS Comput. Biol. 7(7): e1002116
21st Jul 2011

Christoph Kaleta, Luís F de Figueiredo, Sarah Werner, Reinhard Guthke, Michael Ristow, Stefan Schuster

help Authors

[Reinhard Guthke] [Stefan Schuster]

help Attributions

None

help Scales


Not Specified
Views: 1892
  • Created: 18th Jul 2012 at 08:43
  • Last updated: 24th Oct 2013 at 16:18

Related items

Ajax-loader-large

Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network

(v.0.22.0)

Related Projects and friends


Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:

Ror-logo-32

Icons:
Silk icons 1.3
Crystal Clear icons