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Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

Abstract:

The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis.

18602923

Projects: A3.3: Hepatocyte polarity, HepatoSys

Gastroenterology
Gastroenterology 135(2): 642-59
15th May 2008

Steven Dooley, Jafar Hamzavi, Loredana Ciuclan, Patricio Godoy, Iryna Ilkavets, Sabrina Ehnert, Elke Ueberham, Rolf Gebhardt, Stephan Kanzler, Andreas Geier, Katja Breitkopf, Honglei Weng, Peter R Mertens

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[Steven Dooley] [Patricio Godoy] [Iryna Ilkavets] [Rolf Gebhardt] [Katja Breitkopf-Heinlein]

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Views: 2079
  • Created: 24th Feb 2012 at 17:08
  • Last updated: 24th Oct 2013 at 16:22

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