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Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression

Abstract:

Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipogenesis, was shown to be associated with non-alcoholic fatty liver disease, which is attributed to its major isoform SREBP1c. Based on studies in mice, the minor isoform SREBP1a is regarded as negligible for hepatic lipogenesis. This study aims to elucidate the expression and functional role of SREBP1a in human liver.

25634759

Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, Showcase Steatosis

Cell. Physiol. Biochem.
Cell. Physiol. Biochem. 35(2): 803-15
30th Jan 2015

Andreas Bitter, Andreas K Nüssler, Wolfgang E Thasler, Kathrin Klein, Ulrich M Zanger, Matthias Schwab, Oliver Burk

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[Andreas Nüssler] [Wolfgang E. Thasler] [Kathrin Klein] [Ulrich Zanger] [Matthias Schwab]

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Views: 1235
  • Created: 7th Apr 2015 at 14:59

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