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Unraveling liver complexity from molecular to organ level: Challenges and perspectives

Abstract:

Biological responses are determined by information processing at multiple and highly interconnected scales. Within a tissue the individual cells respond to extracellular stimuli by regulating intracellular signaling pathways that in turn determine cell fate decisions and influence the behavior of neighboring cells. As a consequence the cellular responses critically impact tissue composition and architecture. Understanding the regulation of these mechanisms at different scales is key to unravel the emergent properties of biological systems. In this perspective, a multidisciplinary approach combining experimental data with mathematical modeling is introduced. We report the approach applied within the Virtual Liver Network to analyze processes that regulate liver functions from single cell responses to the organ level using a number of examples. By facilitating interdisciplinary collaborations, the Virtual Liver Network studies liver regeneration and inflammatory processes as well as liver metabolic functions at multiple scales, and thus provides a suitable example to identify challenges and point out potential future application of multi-scale systems biology.

10.1016/j.pbiomolbio.2014.11.005

Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., C5: Structural changes and functional consequences of the liver lobular/..., E1: Integration on the cellular level, Interleukin-6 signalling, Showcase HGF and Regeneration

Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology 117(1) : 78
2015

L.A. D'Alessandro, S. Hoehme, A. Henney, D. Drasdo, U. Klingmüller

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[Lorenza D'Alessandro] [Stefan Höhme] [Adriano M. Henney] [Dirk Drasdo] [Ursula Klingmüller]

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Views: 1346
  • Created: 6th Apr 2015 at 12:17
  • Last updated: 9th Jun 2015 at 10:40

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