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morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring

Abstract:

Searching the orthologs of a given protein or DNA sequence is one of the most important and most commonly used Bioinformatics methods in Biology. Programs like BLAST or the orthology search engine Inparanoid can be used to find orthologs when the similarity between two sequences is sufficiently high. They however fail when the level of conservation is low. The detection of remotely conserved proteins oftentimes involves sophisticated manual intervention that is difficult to automate.

25096057

Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., A3: Crosslinking signalling metabolism and hepatocyte polarisation, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...

BMC Bioinformatics
BMC Bioinformatics 15(1): 263
6th Aug 2014

Ines Wagner, Michael Volkmer, Malvika Sharan, Jose M Villaveces, Felix Oswald, Vineeth Surendranath, Bianca H Habermann

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[Jose Villaveces] [Bianca Habermann]

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Views: 1280
  • Created: 11th Aug 2014 at 16:33

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