Predicting idiosyncratic drug-induced liver injury - some recent advances


Drug-induced liver injury (DILI) is a major challenge for the pharmaceutical industry, regulatory authorities, and clinicians. It is usually categorized into 'intrinsic' and 'idiosyncratic', but DILI caused by most drugs is of an idiosyncratic nature and usually cannot be predicted from the regulatory required animal toxicity studies. Unfortunately, some individuals exposed to therapeutic dose will develop idiosyncratic DILI that might involve severe clinical outcome, and no biomarker is available to identify the susceptible patients prior to drug treatment. In this editorial, we summarized the recent advances in predicting idiosyncratic DILI and provided the perspectives to improve the prediction.


Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions

Expert Rev Gastroenterol Hepatol
Expert Rev Gastroenterol Hepatol : 1-3
27th May 2014

Minjun Chen, Jürgen Borlak, Weida Tong

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[Jürgen Borlak]

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Views: 1840
  • Created: 28th Jun 2014 at 16:40

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