Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
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Hedgehog signaling plays an important role in embryonic development, organogenesis and cancer. In the adult liver, Hedgehog signaling in non-parenchymal cells has been found to play a role in certain disease states such as fibrosis and cirrhosis. However, whether the Hedgehog pathway is active in mature healthy hepatocytes and is of significance to liver function are controversial.
Projects: Virtual Liver
Cell Commun. Signal
Cell Commun. Signal 12(1): 11
18th Feb 2014
Madlen Matz-Soja, Susanne Aleithe, Eugenia Marbach, Jan Böttger, Katrin Arnold, Wolfgang Schmidt-Heck, Jürgen Kratzsch, Rolf Gebhardt
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