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A fat option for the pig: Hepatocytic differentiated mesenchymal stem cells for translational research

Abstract:

Study background: Extended liver resection is the only curative treatment option of liver cancer. Yet, the residual liver may not accomplish the high metabolic and regenerative capacity needed, which frequently leads to acute liver failure. Because of their anti-inflammatory and -apoptotic as well as pro-proliferative features, mesenchymal stem cells differentiated into hepatocyte-like cells might provide functional and regenerative compensation. Clinical translation of basic research requires pre-clinical approval in large animals. Therefore, we characterized porcine mesenchymal stem cells (MSC) from adipose tissue and bone marrow and their hepatocyte differentiation potential for future assessment of functional liver support after surgical intervention in the pig model.

24200501

Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis

Exp. Cell Res.
Exp. Cell Res. 321(2): 267-75
4th Nov 2013

Sandra Brückner, Hans-Michael Tautenhahn, Sandra Winkler, Peggy Stock, Matthias Dollinger, Bruno Christ

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[Sandra Brückner] [Bruno Christ] [Karl Winkler]

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Cell and Liver
Views: 1604
  • Created: 10th Feb 2014 at 17:22

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