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Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential

Abstract:

Perforin plays a central role in the immunopathogenesis of different viral infections. However, its role in hepatitis C virus (HCV) infection has not been fully understood. Here, we analyzed two closely related questions: first, is CD8+ T cell-mediated killing of HCV-replicating human hepatoma cells mediated by perforin? Second, if so, do HCV-specific CD8+ T cells obtained from chronically HCV infected patients express and upregulate perforin?

PubMed ID: 22425625

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Journal: J. Hepatol.
Citation: J. Hepatol. 57(1): 9-16
Date Published: 14th Mar 2012

Authors: Juandy Jo, Bertram Bengsch, Bianca Seigel, Sibylle J Rau, Julia Schmidt, Emmanuel Bisse, Peter Aichele, Ulrike Aichele, Lars Joeckel, Cathy Royer, Karine Sá Ferreira, Christoph Borner, Thomas F Baumert, Hubert E Blum, Volker Lohmann, Richard Fischer, Robert Thimme

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