Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential


Perforin plays a central role in the immunopathogenesis of different viral infections. However, its role in hepatitis C virus (HCV) infection has not been fully understood. Here, we analyzed two closely related questions: first, is CD8+ T cell-mediated killing of HCV-replicating human hepatoma cells mediated by perforin? Second, if so, do HCV-specific CD8+ T cells obtained from chronically HCV infected patients express and upregulate perforin?


Projects: No Projects

J. Hepatol.
J. Hepatol. 57(1): 9-16
14th Mar 2012

Juandy Jo, Bertram Bengsch, Bianca Seigel, Sibylle J Rau, Julia Schmidt, Emmanuel Bisse, Peter Aichele, Ulrike Aichele, Lars Joeckel, Cathy Royer, Karine Sá Ferreira, Christoph Borner, Thomas F Baumert, Hubert E Blum, Volker Lohmann, Richard Fischer, Robert Thimme

help Authors

[Christoph Borner]

help Attributions


help Scales

Not Specified
Views: 1988
  • Created: 22nd Jan 2014 at 15:20

Related items


Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network


Related Projects and friends

Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:


Silk icons 1.3
Crystal Clear icons