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DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome

Abstract:

The monocarboxylate transporter 4 (MCT4) is a metabolic target in tumor biology because it mediates lactate transport across membranes resulting in antiapoptotic effects. Cell experiments support the importance of MCT4 in clear cell renal cell carcinoma (ccRCC). In this study, we assessed the prognostic potential of MCT4 expression in ccRCC and its epigenetic regulation by DNA methylation as novel predictive marker for patient outcome using independent ccRCC cohorts.

PubMed ID: 23881922

Projects: B5: Cell-cell communication influences detoxifying functions in hepatocytes, G3: Clinical Translation to Pharmaceutical Drug Development

Journal: Clin. Cancer Res.
Citation: Clin. Cancer Res. 19(18): 5170-81
Date Published: 23rd Jul 2013

Authors: Pascale Fisel, Stephan Kruck, Stefan Winter, Jens Bedke, Jörg Hennenlotter, Anne T Nies, Marcus Scharpf, Falko Fend, Arnulf Stenzl, Matthias Schwab, Elke Schaeffeler

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