Genetics, epigenetics and regulation of drug metabolizing cytochrome P450 enzymes


Of 57 functional human cytochromes P450 (CYP) about a dozen liver-expressed, highly variable forms are responsible for the biotransformation of most drugs. Owing to numerous genetic and non-genetic sources of variation, each individual possesses his/her own, rather unique CYP-profile. Here we explore the potential of new technologies and developments in genetics, epigenetics and regulation of gene expression to increase our understanding of the mechanisms that lead to the enormous inter- and intra-individual variability of these enzymes.Clinical Pharmacology & Therapeutics (2013); accepted article preview online 6 November 2013 doi:10.1038/clpt.2013.220.


Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes

Clin. Pharmacol. Ther.
Clin. Pharmacol. Ther. :
8th Nov 2013

Ulrich M Zanger, Kathrin Klein, Maria Thomas, Jessica K Rieger, Roman Tremmel, Benjamin A Kandel, Marcus Klein, Tarek Magdy

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[Ulrich Zanger] [Kathrin Klein] [Maria Thomas] [Jessica Rieger] [Benjamin Kandel]

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Views: 2080
  • Created: 8th Jan 2014 at 13:58

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