Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models


Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or signal transduction. Integrated models that are able to span and interconnect these layers are, by contrast, rare as their construction and analysis face multiple challenges. Such methods, however, would represent extremely useful tools to understand cell behaviour, with application in distinct fields of biological and medical research. In particular, they could be useful tools to study genotype-phenotype mappings, and the way they are affected by specific conditions or perturbations. Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism. We describe existing challenges, available methods and point at potentially useful strategies.


Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, E: Model integration, Virtual Liver

Mol Biosyst
Mol Biosyst 9(7): 1576-83
26th Mar 2013

Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha, Julio Saez-Rodriguez

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[Anke Ryll] [Klaus Mauch] [Steffen Klamt]

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Cell, Liver and Organism
Views: 2415
  • Created: 3rd Jun 2013 at 16:37
  • Last updated: 24th Oct 2013 at 16:14

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