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Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells

Abstract:

80 - 90% of primary liver cancer cases originate from hepatocellular carcinoma (HCC), which has been regarded as the fifth most common cancer and the third most fatal reason responsible for cancer-related death in the world.(1) Current therapeutic options including surgical resection, liver transplantation and chemoembolization are only used at early stages of HCC with limited efficacy.(2) Cancer recurrence occurs in around 50% of the patients.(3,4) Despite extensive scientific efforts, the prognosis of HCC is nowadays still poor since HCC is inclined to tumor invasiveness and formation of intra- and extra-hepatic metastases.

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Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A3.3: Hepatocyte polarity, B2.1: Hepatic stellate cells as source and target for hepatocellular gro..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd...

Cancer Sci.
Cancer Sci. 104(3): 398-408
4th Jan 2013

Qi Li, Xing Gu, Honglei Weng, Shahrouz Ghafoory, Yan Liu, Teng Feng, Johanna Dzieran, Li Li, Iryna Ilkavets, Marianna Kruithof-de Julio, Stefan Munker, Alexander Marx, Albrecht Piiper, Eduardo Augusto Alonso, Norbert Gretz, Chunfang Gao, Stefan Wölfl, Steven Dooley, Katja Breitkopf-Heinlein

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[Iryna Ilkavets] [Steven Dooley] [Katja Breitkopf-Heinlein]

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Cell
Views: 1763
  • Created: 18th Jan 2013 at 10:41
  • Last updated: 24th Oct 2013 at 16:15

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