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Selective Protection of Human Liver Tissue in TNF-Targeting of Cancers of the Liver by Transient Depletion of Adenosine Triphosphate

Abstract:

Tumor necrosis factor alpha (TNF) is able to kill cancer cells via receptor-mediated cell death requiring adenosine triphosphate (ATP). Clinical usage of TNF so far is largely limited by its profound hepatotoxicity. Recently, it was found in the murine system that specific protection of hepatocytes against TNF's detrimental effects can be achieved by fructose-mediated ATP depletion therein. Before employing this quite attractive selection principle in a first clinical trial, we here comprehensively investigated the interdependence between ATP depletion and TNF hepatotoxicity in both in vitro and ex vivo experiments based on usage of primary patient tissue materials.

23272249

Projects: A3.4: Linking signalling to metabolic functions, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development

PLoS ONE
PLoS ONE 7(12): e52496
18th Dec 2012

Timo Weiland, Kathrin Klein, Martina Zimmermann, Tobias Speicher, Sascha Venturelli, Alexander Berger, Heike Bantel, Alfred Königsrainer, Martin Schenk, Thomas S Weiss, Albrecht Wendel, Matthias Schwab, Michael Bitzer, Ulrich M Lauer

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[Kathrin Klein] [Thomas Weiss] [Matthias Schwab]

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Views: 1814
  • Created: 8th Jan 2013 at 10:43
  • Last updated: 24th Oct 2013 at 16:15

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