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Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer

Abstract:

TGF-β plays a dual role in the progression of human cancer. During the early stages of carcinogenesis, TGF-β functions as a tumor suppressor. During the late stages of tumor development, however, TGF-β can promote tumor growth and metastasis. A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β in colorectal and hepatocellular carcinoma. In the present study, we investigated the potential role of differential Smad2/3 phosphorylation in gastric adenocarcinoma.

22539990

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PLoS ONE
PLoS ONE 7(4): e35684
23rd Apr 2012

Yijun Wu, Qi Li, Xinhui Zhou, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Müllenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Kouichi Matsuzaki, Youming Li, Steven Dooley, Honglei Weng

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[Steven Dooley]

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Views: 1789
  • Created: 31st Oct 2012 at 09:13
  • Last updated: 24th Oct 2013 at 16:16

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