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Reduced modeling of signal transduction - a modular approach

Created: 30th Oct 2012 at 09:04
Last updated: 24th Oct 2013 at 16:23

Abstract:

Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively and a lot of progress has been made within the last few years. A software tool (BioNetGen) was developed which allows an automatic rule-based set-up of mechanistic model equations. In many cases these models can be reduced by an exact domain-oriented lumping technique. However, the resulting models can still consist of a very large number of differential equations.

PubMed ID: 17854494

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Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 8: 336
Date Published: 13th Sep 2007

Authors: Markus Koschorreck, Holger Conzelmann, Sybille Ebert, Michael Ederer, Ernst Dieter Gilles

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