Two to tango: regulation of Mammalian iron metabolism


Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ferroportin, and another that predominantly controls cellular iron metabolism through iron-regulatory proteins that bind iron-responsive elements in regulated messenger RNAs. We describe how the two distinct systems function and how they "tango" together in a coordinated manner. We also highlight some of the current questions in mammalian iron metabolism and discuss therapeutic opportunities arising from a better understanding of the underlying biological principles.


Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag..., HepatoSys

Cell 142(1): 24-38
7th Jul 2010

Matthias W Hentze, Martina U Muckenthaler, Bruno Galy, Clara Camaschella

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[Matthias Hentze] [Martina Muckenthaler] [Bruno Galy]

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Views: 1953
  • Created: 29th Oct 2012 at 11:04
  • Last updated: 24th Oct 2013 at 16:20

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