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Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

Abstract:

MOTIVATION: Mathematical description of biological reaction networks by differential equations leads to large models whose parameters are calibrated in order to optimally explain experimental data. Often only parts of the model can be observed directly. Given a model that sufficiently describes the measured data, it is important to infer how well model parameters are determined by the amount and quality of experimental data. This knowledge is essential for further investigation of model predictions. For this reason a major topic in modeling is identifiability analysis. RESULTS: We suggest an approach that exploits the profile likelihood. It enables to detect structural non-identifiabilities, which manifest in functionally related model parameters. Furthermore, practical non-identifiabilities are detected, that might arise due to limited amount and quality of experimental data. Last but not least confidence intervals can be derived. The results are easy to interpret and can be used for experimental planning and for model reduction. AVAILABILITY: An implementation is freely available for MATLAB and the PottersWheel modeling toolbox at http://web.me.com/andreas.raue/profile/software.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

19505944

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Bioinformatics
Bioinformatics 25(15): 1923-9
8th Jun 2009

A Raue, C Kreutz, T Maiwald, J Bachmann, M Schilling, U Klingmüller, J Timmer

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[Andreas Raue] [Clemens Kreutz] [Thomas Maiwald] [Ursula Klingmüller] [Jens Timmer]

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Views: 2097
  • Created: 10th Dec 2010 at 12:16
  • Last updated: 24th Oct 2013 at 16:21

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