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What mRNA Abundances Can Tell us about Metabolism

Abstract:

Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest in this field can easily be explained by two facts: the high quality of genome-scale metabolic network reconstructions and the highly developed technology to obtain genome-covering RNA profiles. Here, an overview of important algorithmic approaches is given by means of criteria by which published procedures can be classified. The frontiers of the methods are sketched and critical voices are being heard. Finally, an outlook for the prospects of the field is given.

10.3390/metabo2030614

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...

Metabolites
Metabolites 2(4) : 614
1st Sep 2012

Andreas Hoppe

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[Andreas Hoppe]

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Views: 1670
  • Created: 23rd Oct 2012 at 12:30
  • Last updated: 24th Oct 2013 at 16:16

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