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HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

Abstract:

We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions. The network comprises 777 metabolites in six intracellular and two extracellular compartments and 2539 reactions, including 1466 transport reactions. It is based on the manual evaluation of >1500 original scientific research publications to warrant a high-quality evidence-based model. The final network is the result of an iterative process of data compilation and rigorous computational testing of network functionality by means of constraint-based modeling techniques. Taking the hepatic detoxification of ammonia as an example, we show how the availability of nutrients and oxygen may modulate the interplay of various metabolic pathways to allow an efficient response of the liver to perturbations of the homeostasis of blood compounds.

20823849

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1.3: Identification of crucial metabolic processes during hepatocyte pr..., F2: The Liver Knowledge Base (LKB)

Mol. Syst. Biol.
Mol. Syst. Biol. 6: 411
30th Dec 2009

Christoph Gille, Christian Bölling, Andreas Hoppe, Sascha Bulik, Sabrina Hoffmann, Katrin Hübner, Anja Karlstädt, Ramanan Ganeshan, Matthias König, Kristian Rother, Michael Weidlich, Jörn Behre, Herrmann-Georg Holzhütter

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[Christian Bölling] [Andreas Hoppe] [Sascha Bulik] [Matthias König] [Michael Weidlich]
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  • Created: 9th Dec 2010 at 13:39
  • Last updated: 24th Oct 2013 at 16:20

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