Wordprocessing

Oxidative changes of lipids monitored by MALDI MS

Abstract:

Oxidation processes of lipids are of paramount interest from many viewpoints. For instance, oxidation processes are highly important under in vivo conditions because molecules with regulatory functions are generated by oxidation of lipids or free fatty acids. Additionally, many inflammatory diseases are accompanied by lipid oxidation and, therefore, oxidation products are also useful disease (bio)markers. Thus, there is also considerable interest in methods of (oxidized) lipid analysis. Nowadays, soft ionization mass spectrometric (MS) methods are regularly used to study oxidative lipid modifications due to their high sensitivities and the extreme mass resolution. Although electrospray ionization (ESI) MS is so far most popular, applications of matrix-assisted laser desorption and ionization (MALDI) MS are increasing. This review aims to summarize the so far available data on MALDI analyses of oxidized lipids. In addition to model systems, special attention will be paid to the monitoring of oxidized lipids under in vivo conditions, particularly the oxidation of (human) lipoproteins. It is not the aim of this review to praise MALDI as the "best" method but to provide a critical survey of the advantages and drawbacks of this method.

10.1016/j.chemphyslip.2011.09.006

Projects: No Projects

Chemistry and Physics of Lipids
Chemistry and Physics of Lipids 164(8) : 782
1st Nov 2011

Beate Fuchs, Kristin Bresler, Jürgen Schiller

help Authors

[Beate Fuchs] [Jürgen Schiller]

help Attributions

None

help Scales


Not Specified
Views: 1595
  • Created: 4th Aug 2012 at 16:23
  • Last updated: 24th Oct 2013 at 16:17

Related items

Ajax-loader-large

Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network

(v.0.22.0)

Related Projects and friends


Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:

Ror-logo-32

Icons:
Silk icons 1.3
Crystal Clear icons