Publications
Authors: K. Meyer, O. Ostrenko, G. Bourantas, H. Morales-Navarrete, N. Porat-Shliom, F. Segovia-Miranda, H. Nonaka, A. Ghaemi, J. M. Verbavatz, L. Brusch, I. Sbalzarini, Y. Kalaidzidis, R. Weigert, M. Zerial
PubMed ID: 28330614
Date Published: 24th Mar 2017
Projects: Showcase LIAM (Liver Image Analysis Based Model)
Journal: Cell Syst
Citation: Cell Syst. 2017 Mar 15. pii: S2405-4712(17)30052-2. doi: 10.1016/j.cels.2017.02.008.
Scales: Liver lobule
Abstract (Expand)
Created: 25th Jul 2017 at 13:19
Authors: S. Schuster, M. Fichtner, S. Sasso
PubMed ID: 28071669
Date Published: 11th Jan 2017
Projects: Showcase Steatosis
Journal: Sci Rep
Citation: Sci Rep. 2017 Jan 10;7:39821. doi: 10.1038/srep39821.
Authors: Chichi Xie, Lars Ole Schwen, Weiwei Wei, Andrea Schenk, Sara Zafarnia, Felix Gremse, Uta Dahmen
DOI: 10.1371/journal.pone.0160581
Date Published: 5th Aug 2016
Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale
Journal: PLoS ONE
Citation: PLoS ONE 11(8) : e0160581
Scales: Liver
Abstract (Expand)
Created: 26th May 2017 at 09:10  Last updated: 26th May 2017 at 09:12
Authors: Julia Rex, Ute Albrecht, Christian Ehlting, Maria Thomas, Ulrich M. Zanger, Oliver Sawodny, Dieter Häussinger, Michael Ederer, Ronny Feuer, Johannes G. Bode
DOI: 10.1371/journal.pcbi.1005018
Date Published: 27th Jul 2016
Projects: B1: Intercellular communication of hepatocytes and macrophages
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 12(7) : e1005018
Scales: Cell and Intercellular
Abstract (Expand)
Created: 23rd Nov 2016 at 13:29  Last updated: 23rd Nov 2016 at 13:32
Intrahepatic Size Regulation in a Surgical Model: Liver Resection-Induced Liver Regeneration Counteracts the Local Atrophy following Simultaneous Portal Vein Ligation
Authors: Weiwei Wei, Tianjiao Zhang, Haoshu Fang, Olaf Dirsch, Andrea Schenk, André Homeyer, Felix Gremse, Sara Zafarnia, Utz Settmacher, Uta Dahmen
DOI: 10.1159/000446875
Date Published: 5th Jul 2016
Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale
Journal: Eur Surg Res
Citation: Eur Surg Res 57(1-2) : 125
Scales: Liver
Abstract (Expand)
Created: 26th May 2017 at 10:43  Last updated: 26th May 2017 at 10:45
Establishment of a rat model: Associating liver partition with portal vein ligation for staged hepatectomy
Authors: Weiwei Wei, Tianjiao Zhang, Sara Zafarnia, Andrea Schenk, Chichi Xie, Chunyi Kan, Olaf Dirsch, Utz Settmacher, Uta Dahmen
DOI: 10.1016/j.surg.2015.12.005
Date Published: 1st May 2016
Projects: D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale
Journal: Surgery
Citation: Surgery 159(5) : 1299
Scales: Liver
Abstract (Expand)
Created: 26th May 2017 at 10:46  Last updated: 26th May 2017 at 10:47
Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades
Authors: Z. Liu, Y. Wang, J. Borlak, W. Tong
PubMed ID: 27045805
Date Published: 6th Apr 2016
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Sci Rep
Citation: Sci Rep. 2016 Apr 5;6:23709. doi: 10.1038/srep23709.
Authors: Lars Ole Schwen, André Homeyer, Michael Schwier, Uta Dahmen, Olaf Dirsch, Arne Schenk, Lars Kuepfer, Tobias Preusser, Andrea Schenk
DOI: 10.1016/j.compbiomed.2016.04.004
Date Published: 1st Apr 2016
Projects: C1: The role of blood flow in liver lobule function and morphology, D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales, Showcase Steatosis
Journal: Computers in Biology and Medicine
Citation: Computers in Biology and Medicine
Scales: Cell, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 13th Apr 2016 at 15:13  Last updated: 13th Apr 2016 at 15:16
Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse
Authors: J. Zhang, K. He, L. Cai, Y. C. Chen, Y. Yang, Q. Shi, T. F. Woolf, W. Ge, L. Guo, J. Borlak, W. Tong
PubMed ID: 27000539
Date Published: 24th Mar 2016
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Chem Biol Interact
Citation: Chem Biol Interact. 2016 Mar 19. pii: S0009-2797(16)30089-8. doi: 10.1016/j.cbi.2016.03.019.
Authors: E. H. Lee, J. H. Oh, S. Selvaraj, S. M. Park, M. S. Choi, R. Spanel, S. Yoon, J. Borlak
PubMed ID: 26934552
Date Published: 5th Mar 2016
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Oncotarget
Citation: Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7698.
Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling
Authors: Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F. Templin, Thomas O. Joos, Wolfgang E. Thasler, Andreas Zell, Ulrich M. Zanger
DOI: 10.1371/journal.pcbi.1004431
Date Published: 4th Jan 2016
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 12(1) : e1004431
Scales: Cell
Abstract (Expand)
Created: 7th Jan 2016 at 15:20  Last updated: 7th Jan 2016 at 15:24
Authors: Chichi Xie, Weiwei Wei, Andrea Schenk, Lars Ole Schwen, Sara Zafarnia, Michael Schwier, Felix Gremse, Isabel Jank, Olaf Dirsch, Uta Dahmen
DOI: 10.3791/53935
Date Published: 2016
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: JoVE
Citation: JoVE (115)
Scales: Liver
Abstract (Expand)
Created: 14th Sep 2016 at 10:17  Last updated: 14th Sep 2016 at 10:20
Authors: N. J. Stanford, K. Wolstencroft, M. Golebiewski, R. Kania, N. Juty, C. Tomlinson, S. Owen, S. Butcher, H. Hermjakob, N. Le Novere, W. Mueller, J. Snoep, C. Goble
PubMed ID: 26700851
Date Published: 25th Dec 2015
Projects: F1: The data management system, Virtual Liver
Journal: Mol Syst Biol
Citation: Mol Syst Biol. 2015 Dec 23;11(12):851. doi: 10.15252/msb.20156053.
Scales: Not specified
Abstract:
Created: 8th Jan 2016 at 09:38
Authors: Andreas Dräger, Daniel C Zielinski, Roland Keller, Matthias Rall, Johannes Eichner, Bernhard O Palsson, Andreas Zell
DOI: 10.1186/s12918-015-0212-9
Date Published: 1st Dec 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 9(1) : 389
Scales: Cell and Intercellular
Abstract (Expand)
Created: 16th Nov 2015 at 15:27  Last updated: 16th Nov 2015 at 15:29
Authors: Constanze Sänger, Andrea Schenk, Lars Ole Schwen, Lei Wang, Felix Gremse, Sara Zafarnia, Fabian Kiessling, Chichi Xie, Weiwei Wei, Beate Richter, Olaf Dirsch, Uta Dahmen
DOI: 10.1371/journal.pone.0141798
Date Published: 30th Nov 2015
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, D4: Regeneration and Liver Size, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: PLoS ONE
Citation: PLoS ONE 10(11) : e0141798
Scales: Liver
Abstract (Expand)
Created: 13th Jan 2016 at 08:00  Last updated: 13th Jan 2016 at 08:03
Authors: K. Abshagen, M. Konig, A. Hoppe, I. Muller, M. Ebert, H. Weng, H. G. Holzhutter, U. M. Zanger, J. Bode, B. Vollmar, M. Thomas, S. Dooley
PubMed ID: 26589287
Date Published: 20th Nov 2015
Projects: A1: Cellular metabolism, A2: Integration of Signalling Pathways in Hepatocellular Response, A3: Crosslinking signalling metabolism and hepatocyte polarisation, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level, D: Whole organ level
Journal: BMC Syst Biol
Citation: BMC Syst Biol. 2015 Nov 20;9(1):83.
Scales: Cell, Liver lobule and Liver
Abstract (Expand)
Created: 23rd Nov 2015 at 07:41
Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles
Authors: J. Zhang, U. Doshi, A. Suzuki, C. W. Chang, J. Borlak, A. P. Li, W. Tong
PubMed ID: 26581450
Date Published: 20th Nov 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Chem Biol Interact
Citation: Chem Biol Interact. 2015 Nov 12. pii: S0009-2797(15)30110-1. doi: 10.1016/j.cbi.2015.11.008.
Authors: B. Christ, S. Bruckner, S. Winkler
PubMed ID: 26476857
Date Published: 22nd Oct 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Trends Mol Med
Citation: Trends Mol Med. 2015 Nov;21(11):673-86. doi: 10.1016/j.molmed.2015.09.004. Epub 2015 Oct 22.
Virtual pathway explorer (viPEr) and pathway enrichment analysis tool (PEANuT): creating and analyzing focus networks to identify cross-talk between molecules and pathways
Authors: M. Garmhausen, F. Hofmann, V. Senderov, M. Thomas, B. A. Kandel, B. H. Habermann
PubMed ID: 26467653
Date Published: 14th Oct 2015
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: BMC Genomics
Citation: BMC Genomics. 2015 Oct 14;16(1):790. doi: 10.1186/s12864-015-2017-z.
Scales: Not specified
Abstract (Expand)
Created: 18th Dec 2015 at 12:55
Authors: M. Bartl, M. Pfaff, A. Ghallab, D. Driesch, S. G. Henkel, J. G. Hengstler, S. Schuster, C. Kaleta, R. Gebhardt, S. Zellmer, P. Li
PubMed ID: 26438405
Date Published: 5th Oct 2015
Projects: C3: Zonation of metabolism and its regulation
Journal: Arch Toxicol
Citation: Arch Toxicol. 2015 Nov;89(11):2069-78. doi: 10.1007/s00204-015-1596-4. Epub 2015 Oct 5.
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 11th Dec 2015 at 09:07
Authors: M. G. Mooij, A. T. Nies, C. A. Knibbe, E. Schaeffeler, D. Tibboel, M. Schwab, S. N. de Wildt
PubMed ID: 26410689
Date Published: 28th Sep 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacokinet
Citation: Clin Pharmacokinet. 2015 Sep 26.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:53
Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types
Authors: H. Stark, M. Fichtner, R. Konig, S. Lorkowski, S. Schuster
PubMed ID: 26382968
Date Published: 14th Sep 2015
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Biochimie
Citation: Biochimie. 2015 Nov;118:185-94. doi: 10.1016/j.biochi.2015.09.017. Epub 2015 Sep 14.
Authors: J. Matthaei, J. Brockmoller, M. V. Tzvetkov, D. Sehrt, C. Sachse-Seeboth, J. B. Hjelmborg, S. Moller, U. Halekoh, U. Hofmann, M. Schwab, R. Kerb
PubMed ID: 26344676
Date Published: 8th Sep 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacol Ther
Citation: Clin Pharmacol Ther. 2015 Sep 7. doi: 10.1002/cpt.258.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:46
Authors: F. Schreiber, G. D. Bader, M. Golebiewski, M. Hucka, B. Kormeier, N. Le Novere, C. Myers, D. Nickerson, B. Sommer, D. Waltemath, S. Weise
PubMed ID: 26528556
Date Published: 4th Sep 2015
Projects: F1: The data management system, Virtual Liver
Journal: J Integr Bioinform
Citation: J Integr Bioinform. 2015 Sep 4;12(2):258. doi: 10.2390/biecoll-jib-2015-258.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 09:15
LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods
Authors: R. Feuer, S. Vlaic, J. Arlt, O. Sawodny, U. Dahmen, U. M. Zanger, M. Thomas
PubMed ID: 26325269
Date Published: 1st Sep 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase LPS and Inflammation
Journal: PLoS One
Citation: PLoS One. 2015 Sep 1;10(9):e0135852. doi: 10.1371/journal.pone.0135852. eCollection 2015.
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: CYP Expression and Induction by Nuclear Receptor Agonists
Authors: A. Braeuning, M. Thomas, U. Hofmann, S. Vetter, E. Zeller, B. Petzuch, J. Johanning, W. Schroth, T. S. Weiss, U. M. Zanger, M. Schwarz
PubMed ID: 26310804
Date Published: 28th Aug 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Drug Metab Dispos
Citation: Drug Metab Dispos. 2015 Aug 26. pii: dmd.115.064667.
Mouse white adipose tissue-derived mesenchymal stem cells gain pericentral and periportal hepatocyte features after differentiation in vitro, which are preserved in vivo after hepatic transplantation
Authors: S. Winkler, M. Hempel, S. Bruckner, F. Mallek, A. Weise, T. Liehr, H. M. Tautenhahn, M. Bartels, B. Christ
PubMed ID: 26235702
Date Published: 19th Aug 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Acta Physiol (Oxf)
Citation: Acta Physiol (Oxf). 2015 Oct;215(2):89-104. doi: 10.1111/apha.12560. Epub 2015 Aug 19.
Scales: Liver lobule
Abstract (Expand)
Created: 11th Nov 2015 at 11:22
Authors: Michael Martinez, Neil J. Bruce, Julia Romanowska, Daria B. Kokh, Musa Ozboyaci, Xiaofeng Yu, Mehmet Ali Öztürk, Stefan Richter, Rebecca C. Wade
DOI: 10.1002/jcc.23971
Date Published: 5th Aug 2015
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: J. Comput. Chem.
Citation: J. Comput. Chem. 36(21) : 1631
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 11:12  Last updated: 18th Sep 2015 at 12:36
Authors: Nadinath B. Nillegoda, Janine Kirstein, Anna Szlachcic, Mykhaylo Berynskyy, Antonia Stank, Florian Stengel, Kristin Arnsburg, Xuechao Gao, Annika Scior, Ruedi Aebersold, D. Lys Guilbride, Rebecca C. Wade, Richard I. Morimoto, Matthias P. Mayer, Bernd Bukau
DOI: 10.1038/nature14884
Date Published: 5th Aug 2015
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Nature
Citation: Nature 524(7564) : 247
Scales: Organism
Abstract (Expand)
Created: 18th Sep 2015 at 13:35  Last updated: 18th Sep 2015 at 13:41
Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors
Authors: A. Emami Riedmaier, O. Burk, B. A. van Eijck, E. Schaeffeler, K. Klein, S. Fehr, S. Biskup, S. Muller, S. Winter, U. M. Zanger, M. Schwab, A. T. Nies
PubMed ID: 26239079
Date Published: 5th Aug 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Pharmacogenomics J
Citation: Pharmacogenomics J. 2015 Aug 4. doi: 10.1038/tpj.2015.55.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:49
Authors: Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, María Matilde Bartolomé Rodríguez, Lars Kuepfer, Tobias Preusser
DOI: 10.1371/journal.pone.0133653
Date Published: 29th Jul 2015
Projects: C1: The role of blood flow in liver lobule function and morphology, D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: PLoS ONE
Citation: PLoS ONE 10(7) : e0133653
Scales: Cell, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 30th Jul 2015 at 09:09  Last updated: 30th Jul 2015 at 09:13
Authors: K. Wolstencroft, S. Owen, O. Krebs, Q. Nguyen, N. J. Stanford, M. Golebiewski, A. Weidemann, M. Bittkowski, L. An, D. Shockley, J. L. Snoep, W. Mueller, C. Goble
PubMed ID: 26160520
Date Published: 11th Jul 2015
Projects: F1: The data management system, Virtual Liver
Journal: BMC Syst Biol
Citation: BMC Syst Biol. 2015 Jul 11;9:33. doi: 10.1186/s12918-015-0174-y.
Scales: Not specified
Abstract (Expand)
Created: 7th Aug 2015 at 11:48
The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates proliferative and pro-inflammatory genes
Authors: M. Thomas, C. Bayha, K. Klein, S. Muller, T. S. Weiss, M. Schwab, U. M. Zanger
PubMed ID: 26122096
Date Published: 30th Jun 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Cancer
Citation: BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x.
Scales: Not specified
Abstract (Expand)
Created: 17th Sep 2015 at 10:19
Authors: Xiaofeng Yu, Michael Martinez, Annika L. Gable, Jonathan C. Fuller, Neil J. Bruce, Stefan Richter, Rebecca C. Wade
DOI: 10.1093/nar/gkv335
Date Published: 30th Jun 2015
Projects: F3: Kinetic data handling
Journal: Nucleic Acids Res
Citation: Nucleic Acids Res 43(W1) : W220
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 13:33  Last updated: 18th Sep 2015 at 13:34
Authors: Endre T Somogyi, Jean-Marie Bouteiller, James A Glazier, Matthias König, J Kyle Medley, Maciej H Swat, Herbert M Sauro
PubMed ID: 26085503
Date Published: 19th Jun 2015
Projects: No Projects
Journal: Bioinformatics
Citation: Bioinformatics :
Scales: Not specified
Abstract (Expand)
Created: 1st Jul 2015 at 16:00
Authors: N. Rodriguez, A. Thomas, L. Watanabe, I. Y. Vazirabad, V. Kofia, H. F. Gomez, F. Mittag, J. Matthes, J. Rudolph, F. Wrzodek, E. Netz, A. Diamantikos, J. Eichner, R. Keller, C. Wrzodek, S. Frohlich, N. E. Lewis, C. J. Myers, N. Le Novere, B. O. Palsson, M. Hucka, A. Drager
PubMed ID: 26079347
Date Published: 17th Jun 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Bioinformatics
Citation: Bioinformatics :
Scales: Cell, Intercellular, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 22nd Jun 2015 at 17:56
Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe
Authors: F. Malentacchi, I. Mancini, I. Brandslund, P. Vermeersch, M. Schwab, J. Marc, R. H. van Schaik, G. Siest, E. Theodorsson, M. Pazzagli, C. Di Resta
PubMed ID: 26036226
Date Published: 4th Jun 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Drug Metabol Personal Ther
Citation: Drug Metabol Personal Ther. 2015 Jun;30(2):121-8. doi: 10.1515/dmdi-2015-0012.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:44
Authors: J. M. Villaveces, P. Koti, B. H. Habermann
PubMed ID: 26082651
Date Published: 4th Jun 2015
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Adv Appl Bioinform Chem
Citation: Adv Appl Bioinform Chem. 2015 Jun 4;8:11-22. doi: 10.2147/AABC.S63534. eCollection 2015.
Scales: Not specified
Abstract (Expand)
Created: 18th Dec 2015 at 12:57
Authors: André Homeyer, Andrea Schenk, Janine Arlt, Uta Dahmen, Olaf Dirsch, Horst K. Hahn
DOI: 10.1016/j.cmpb.2015.05.009
Date Published: 1st Jun 2015
Projects: D4: Regeneration and Liver Size, Showcase Steatosis
Journal: Computer Methods and Programs in Biomedicine
Citation: Computer Methods and Programs in Biomedicine
Scales: Cell, Liver lobule and Liver
Abstract (Expand)
Created: 25th Jun 2015 at 09:02  Last updated: 29th Jun 2015 at 09:38
Authors: Christoph Meyer, Roman Liebe, Katja Breitkopf-Heinlein, Yan Liu, Alexandra Müller, Pia Rakoczy, Maria Thomas, Honglei Weng, Anastasia Bachmann, Matthias Ebert, Steven Dooley
PubMed ID: 25982745
Date Published: 20th May 2015
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A3.3: Hepatocyte polarity
Journal: Differentiation
Citation: Differentiation :
Authors: Julia Romanowska, Daria B. Kokh, Jonathan C. Fuller, Rebecca C. Wade
DOI: 10.1002/9783527673025.ch11
Date Published: 11th May 2015
Projects: F3: Kinetic data handling
Book: Thermodynamics and Kinetics of Drug Binding
Citation: Methods and Principles in Medicinal Chemistry : 211
Scales: Cell
Abstract (Expand)
Created: 18th Sep 2015 at 13:23  Last updated: 18th Sep 2015 at 13:26
Authors: Minjun Chen, Ayako Suzuki, Jürgen Borlak, Raúl J Andrade, M Isabel Lucena
PubMed ID: 25912521
Date Published: 29th Apr 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: J. Hepatol.
Citation: J. Hepatol. :
Scales: Not specified
Abstract (Expand)
Created: 5th May 2015 at 09:06
Authors: Lorenza A. D’Alessandro, Regina Samaga, Tim Maiwald, Seong-Hwan Rho, Sandra Bonefas, Andreas Raue, Nao Iwamoto, Alexandra Kienast, Katharina Waldow, Rene Meyer, Marcel Schilling, Jens Timmer, Steffen Klamt, Ursula Klingmüller
DOI: 10.1371/journal.pcbi.1004192
Date Published: 23rd Apr 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A2: Integration of Signalling Pathways in Hepatocellular Response, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.4: Linking signalling to metabolic functions, E1: Integration on the cellular level, Showcase HGF and Regeneration
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 11(4) : e1004192
Scales: Cell
Abstract (Expand)
Created: 5th May 2015 at 13:29  Last updated: 22nd May 2015 at 08:57
Regulation of Liver Enriched Transcription Factors in Rat Hepatocytes Cultures on Collagen and EHS Sarcoma Matrices
Authors: Jürgen Borlak, Prafull Kumar Singh, Ina Rittelmeyer
PubMed ID: 25901575
Date Published: 22nd Apr 2015
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: PLoS ONE
Citation: PLoS ONE 10(4): e0124867
Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant
Authors: R. Arlanov, T. Lang, G. Jedlitschky, E. Schaeffeler, T. Ishikawa, M. Schwab, A. T. Nies
PubMed ID: 25896536
Date Published: 22nd Apr 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Pharmacogenomics J
Citation: Pharmacogenomics J. 2015 Apr 21. doi: 10.1038/tpj.2015.27.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:41
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
Authors: S. Wolking, E. Schaeffeler, H. Lerche, M. Schwab, A. T. Nies
PubMed ID: 25860377
Date Published: 11th Apr 2015
Projects: G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin Pharmacokinet
Citation: Clin Pharmacokinet. 2015 Jul;54(7):709-35. doi: 10.1007/s40262-015-0267-1.
Scales: Not specified
Abstract (Expand)
Created: 17th Dec 2015 at 11:51
Activating and Inhibitory Functions of WNT/β-catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells
Authors: Maria Thomas, Christine Bayha, Silvia Vetter, Ute Hofmann, Michael Schwarz, Ulrich M Zanger, Albert Braeuning
PubMed ID: 25824487
Date Published: 1st Apr 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. :
Authors: Osvaldo Chara, Lutz Brusch
DOI: 10.1016/j.biosystems.2015.02.004
Date Published: 1st Apr 2015
Projects: A3.3: Hepatocyte polarity, A3.5: The impact of cell polarity on metabolism detoxification and endoc..., Showcase LIAM (Liver Image Analysis Based Model)
Journal: Biosystems
Citation: Biosystems 130 : 1
Scales: Cell and Liver lobule
Abstract (Expand)
Created: 30th Apr 2015 at 15:04  Last updated: 30th Apr 2015 at 15:08
Authors: Stefan Ohrnberger, Abhishek Thavamani, Albert Braeuning, Daniel B. Lipka, Milen Kirilov, Robert Geffers, Stella E. Authenrieth, Michael Römer, Andreas Zell, Michael Bonin, Michael Schwarz, Günther Schütz, Peter Schirmacher, Christoph Plass, Thomas Longerich, Alfred Nordheim
DOI: 10.1002/hep.27539
Date Published: 1st Mar 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Hepatology
Citation: Hepatology 61(3) : 979
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 14th Dec 2015 at 15:12  Last updated: 14th Dec 2015 at 15:15
Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events
Authors: Jürgen Borlak, Prashant Singh, Giuseppe Gazzana
PubMed ID: 25872475
Date Published: 25th Feb 2015
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: BMC Genomics
Citation: BMC Genomics 16: 124
Promoting Coordinated Development of Community-Based Information Standards for Modeling in Biology: The COMBINE Initiative
Authors: Michael Hucka, David P. Nickerson, Gary D. Bader, Frank T. Bergmann, Jonathan Cooper, Emek Demir, Alan Garny, Martin Golebiewski, Chris J. Myers, Falk Schreiber, Dagmar Waltemath, Nicolas Le Novère
Date Published: 24th Feb 2015
Projects: F1: The data management system, Virtual Liver
Journal: Front. Bioeng. Biotechnol.
Citation: Front. Bioeng. Biotechnol. 3
Scales: Not specified
Abstract (Expand)
Created: 25th Feb 2015 at 12:58  Last updated: 25th Feb 2015 at 13:01
Authors: M. Hempel, A. Schmitz, S. Winkler, O. Kucukoglu, S. Bruckner, C. Niessen, B. Christ
PubMed ID: 25687506
Date Published: 17th Feb 2015
Projects: C6: Organization and function of the sinusoidal system and the liver lob...
Journal: Cell Mol Life Sci
Citation: Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.
Scales: Liver lobule
Abstract (Expand)
Created: 11th Nov 2015 at 11:12
Zonation of hepatic fatty acid metabolism - The diversity of its regulation and the benefit of modeling
Authors: J Schleicher, C Tokarski, E Marbach, M Matz-Soja, S Zellmer, R Gebhardt, S Schuster
PubMed ID: 25677822
Date Published: 14th Feb 2015
Projects: C3: Zonation of metabolism and its regulation
Journal: Biochim. Biophys. Acta
Citation: Biochim. Biophys. Acta :
Scales: Intercellular and Liver lobule
Abstract (Expand)
Created: 26th Feb 2015 at 09:40
Authors: Sylvie Schulze, Sebastian G. Henkel, Dominik Driesch, Reinhard Guthke, Jörg Linde
Date Published: 6th Feb 2015
Scales: Cell and Intercellular
Abstract:
Created: 11th Feb 2015 at 08:18  Last updated: 11th Feb 2015 at 08:24
Authors: Aidan Budd, Manuel Corpas, Michelle D. Brazas, Jonathan C. Fuller, Jeremy Goecks, Nicola J. Mulder, Magali Michaut, B. F. Francis Ouellette, Aleksandra Pawlik, Niklas Blomberg
DOI: 10.1371/journal.pcbi.1003972
Date Published: 5th Feb 2015
Projects: No Projects
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 11(2) : e1003972
Scales: Not specified
Abstract (Expand)
Created: 9th Feb 2015 at 13:55  Last updated: 9th Feb 2015 at 14:06
Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation
Authors: Hai Li, Qiang Xia, Bo Zeng, Shu-Ting Li, Heng Liu, Qi Li, Jun Li, Shu-Yin Yang, Xiao-Jun Dong, Ting Gao, Stefan Munker, Yan Liu, Roman Liebe, Feng Xue, Qi-Gen Li, Xiao-Song Chen, Qiang Liu, Hui Zeng, Ji-Yao Wang, Qing Xie, Qin-Hua Meng, Jie-Fei Wang, Peter R Mertens, Frank Lammert, Manfred V Singer, Steven Dooley, Matthias P A Ebert, De-Kai Qiu, Tai-Ling Wang, Hong-Lei Weng
PubMed ID: 25646889
Date Published: 4th Feb 2015
Projects: C5: Structural changes and functional consequences of the liver lobular/...
Journal: J. Hepatol.
Citation: J. Hepatol. :
Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression
Authors: Andreas Bitter, Andreas K Nüssler, Wolfgang E Thasler, Kathrin Klein, Ulrich M Zanger, Matthias Schwab, Oliver Burk
PubMed ID: 25634759
Date Published: 30th Jan 2015
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, Showcase Steatosis
Journal: Cell. Physiol. Biochem.
Citation: Cell. Physiol. Biochem. 35(2): 803-15
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:59
Authors: Aidan Budd, Holger Dinkel, Manuel Corpas, Jonathan C. Fuller, Laura Rubinat, Damien P. Devos, Pierre H. Khoueiry, Konrad U. Förstner, Fotis Georgatos, Francis Rowland, Malvika Sharan, Janos X. Binder, Tom Grace, Karyn Traphagen, Adam Gristwood, Natasha T. Wood
DOI: 10.1371/journal.pcbi.1003905
Date Published: 29th Jan 2015
Projects: No Projects
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 11(1) : e1003905
Scales: Not specified
Abstract:
Created: 2nd Feb 2015 at 14:43  Last updated: 2nd Feb 2015 at 14:47
Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma
Authors: Teng Feng, Johanna Dzieran, Xing Gu, Silke Marhenke, Arndt Vogel, Keigo Machida, Thomas S Weiss, Petra Ruemmele, Otto Kollmar, Patrick Hoffmann, Friedrich Grässer, Heike Allgayer, Jasmin Fabian, Hong Lei Weng, Andreas Teufel, Thorsten Maass, Christoph Meyer, Ulrich Lehmann, Cheng Zhu, Peter R Mertens, Chun Fang Gao, Steven Dooley, Nadja M Meindl-Beinker
PubMed ID: 25602745
Date Published: 21st Jan 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd...
Journal: Clin. Sci.
Citation: Clin. Sci. 128(11): 761-74
Authors: Felix Gremse, Andreas Höfter, Lars Ole Schwen, Fabian Kiessling, Uwe Naumann
DOI: 10.1137/130948811
Date Published: 8th Jan 2015
Projects: D3: Inflammation and Regeneration: the whole organ
Journal: SIAM J. Sci. Comput.
Citation: SIAM J. Sci. Comput. 37(1) : C54
Scales: Organism
Abstract (Expand)
Created: 26th Jan 2015 at 16:56  Last updated: 26th Jan 2015 at 17:01
Authors: Anne T Nies, Tarek Magdy, Matthias Schwab, Ulrich M Zanger
PubMed ID: 25640272
Date Published: 8th Jan 2015
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Adv. Cancer Res.
Citation: Adv. Cancer Res. 125: 217-43
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:52
Authors: Christian Ehlting, Oliver Böhmer, Maximilian J Hahnel, Maria Thomas, Ulrich M Zanger, Matthias Gaestel, Wolfram T Knoefel, Jan Schulte Am Esch, Dieter Häussinger, Johannes G Bode
PubMed ID: 25562430
Date Published: 7th Jan 2015
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A: Cellular level
Journal: Cell. Signal.
Citation: Cell. Signal. :
Scales: Not specified
Abstract (Expand)
Created: 7th Jan 2015 at 14:25
Mathematical Modelling suggests Differential Impact of β-TrCP Paralogues on Wnt/β-catenin Signalling Dynamics
Authors: Uwe Benary, Bente Kofahl, Andreas Hecht, Jana Wolf
DOI: 10.1111/febs.13204
Date Published: 2015
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.2: Importance of Wnt- and Hedgehog factors for hepatic stellate cells...
Journal: FEBS J
Citation: FEBS J : n/a
Scales: Cell
Abstract (Expand)
Created: 20th Jan 2015 at 07:51  Last updated: 20th Jan 2015 at 07:52
Authors: Federico Pinna, Kai Breuhahn
DOI: 10.2217/hep.14.29
Date Published: 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga...
Journal: Hepatic Oncology
Citation: Hepatic Oncology 2(1) : 9
Scales: Cell and Intercellular
Abstract:
Created: 20th Jan 2015 at 13:49  Last updated: 20th Jan 2015 at 13:52
Authors: L.A. D'Alessandro, S. Hoehme, A. Henney, D. Drasdo, U. Klingmüller
DOI: 10.1016/j.pbiomolbio.2014.11.005
Date Published: 2015
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., C5: Structural changes and functional consequences of the liver lobular/..., E1: Integration on the cellular level, Interleukin-6 signalling, Showcase HGF and Regeneration
Journal: Progress in Biophysics and Molecular Biology
Citation: Progress in Biophysics and Molecular Biology 117(1) : 78
Scales: Not specified
Abstract (Expand)
Created: 6th Apr 2015 at 12:17  Last updated: 9th Jun 2015 at 10:40
Authors: Adriano Henney, Peter Hunter, Andrew McCulloch, Denis Noble
DOI: 10.1016/j.pbiomolbio.2015.03.001
Date Published: 2015
Projects: No Projects
Journal: Progress in Biophysics and Molecular Biology
Citation: Progress in Biophysics and Molecular Biology 117(1) : 1
Scales: Not specified
Abstract:
Created: 6th Apr 2015 at 12:20  Last updated: 6th Apr 2015 at 12:21
Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes
Authors: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort
DOI: 10.1371/journal.pone.0115603
Date Published: 31st Dec 2014
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 9(12) : e115603
Scales: Cell
Abstract (Expand)
Created: 23rd Jan 2015 at 09:58  Last updated: 23rd Jan 2015 at 10:00
Authors: Frank T Bergmann, Richard Adams, Stuart Moodie, Jonathan Cooper, Mihai Glont, Martin Golebiewski, Michael Hucka, Camille Laibe, Andrew K Miller, David P Nickerson, Brett G Olivier, Nicolas Rodriguez, Herbert M Sauro, Martin Scharm, Stian Soiland-Reyes, Dagmar Waltemath, Florent Yvon, Nicolas Le Novère
PubMed ID: 25494900
Date Published: 14th Dec 2014
Projects: F1: The data management system
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 15(1): 369
Scales: Not specified
Abstract (Expand)
Created: 9th Jan 2015 at 15:06
A Systematic Comparison of the Impact of Inflammatory Signaling on ADME Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells
Authors: Marcus Klein, Maria Thomas, Ute Hofmann, Daniel Seehofer, Georg Damm, Ulrich M Zanger
PubMed ID: 25480923
Date Published: 7th Dec 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, Showcase LPS and Inflammation, Showcase Steatosis
Journal: Drug Metab. Dispos.
Citation: Drug Metab. Dispos. :
Scales: Not specified
Abstract (Expand)
Created: 7th Dec 2014 at 10:17
Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome
Authors: Nishika Sahini, Saravanakumar Selvaraj, Jürgen Borlak
PubMed ID: 25470483
Date Published: 3rd Dec 2014
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: PLoS ONE
Citation: PLoS ONE 9(12): e114085
Authors: David Zakim, Matthias Schwab
PubMed ID: 25479798
Date Published: 2nd Dec 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Trends Pharmacol. Sci.
Citation: Trends Pharmacol. Sci. 36(2): 68-71
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:54
Authors: Alexander Dörr, Roland Keller, Andreas Zell, Andreas Dräger
DOI: 10.3390/computation2040246
Date Published: 1st Dec 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Computation
Citation: Computation 2(4) : 246
Scales: Cell and Intercellular
Abstract (Expand)
Created: 14th Jan 2015 at 15:05  Last updated: 10th Jun 2015 at 18:36
Authors: J. C. Fuller, M. Martinez, S. Henrich, A. Stank, S. Richter, R. C. Wade
DOI: 10.1093/bioinformatics/btu784
Date Published: 29th Nov 2014
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., F3: Kinetic data handling
Journal: Bioinformatics
Citation: Bioinformatics
Scales: Cell
Abstract (Expand)
Created: 6th Dec 2014 at 18:03  Last updated: 6th Dec 2014 at 18:07
Authors: C Priesnitz, S Sperber, R Garg, M Orsini, F Noor
PubMed ID: 25424145
Date Published: 26th Nov 2014
Projects: A1: Cellular metabolism, C3: Zonation of metabolism and its regulation
Journal: Cytotechnology
Citation: Cytotechnology :
Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here
Authors: A Emami-Riedmaier, E Schaeffeler, A T Nies, K Mörike, M Schwab
PubMed ID: 25418285
Date Published: 25th Nov 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: J. Intern. Med.
Citation: J. Intern. Med. 277(2): 235-47
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:50
Authors: Elisa Pfeiffer, Victoria Kegel, Katrin Zeilinger, Jan G Hengstler, Andreas K Nüssler, Daniel Seehofer, Georg Damm
PubMed ID: 25394621
Date Published: 15th Nov 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., CTU Liver bank
Journal: Exp. Biol. Med. (Maywood)
Citation: Exp. Biol. Med. (Maywood) :
Scales: Cell and Intercellular
Abstract (Expand)
Created: 5th Jan 2015 at 13:19
Authors: Lars Ole Schwen, Weiwei Wei, Felix Gremse, Josef Ehling, Lei Wang, Uta Dahmen, Tobias Preusser
DOI: 10.1016/j.jtbi.2014.10.026
Date Published: 1st Nov 2014
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales
Journal: Journal of Theoretical Biology
Citation: Journal of Theoretical Biology
Scales: Liver
Abstract (Expand)
Created: 17th Nov 2014 at 10:07  Last updated: 17th Nov 2014 at 10:12
Authors: Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G. Hengstler
DOI: 10.1007/s00204-014-1384-6
Date Published: 21st Oct 2014
Projects: No Projects
Journal: Arch Toxicol
Citation: Arch Toxicol
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:06  Last updated: 7th Nov 2014 at 15:06
Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma
Authors: Stefan Welte, Toni Urbanik, Christin Elßner, Nicole Kautz, Bruno Christian Koehler, Nina Waldburger, Justo Lorenzo Bermejo, Federico Pinna, Karl-Heinz Weiss, Peter Schemmer, Dirk Jaeger, Thomas Longerich, Kai Breuhahn, Henning Schulze-Bergkamen
DOI: 10.1371/journal.pone.0110591
Date Published: 16th Oct 2014
Projects: A2.1: Multi-level regulation of signalling pathways important for primin...
Journal: PLoS ONE
Citation: PLoS ONE 9(10) : e110591
Scales: Cell
Abstract:
Created: 20th Jan 2015 at 13:44  Last updated: 20th Jan 2015 at 13:46
Authors: Veronica Murahovschi, Olga Pivovarova, Iryna Ilkavets, Renata M Dmitrieva, Stephanie Döcke, Farnaz Keyhani-Nejad, Özlem Gögebakan, Martin Osterhoff, Margrit Kemper, Silke Hornemann, Mariya Markova, Nora Klöting, Martin Stockmann, Martin O Weickert, Valeria Lamounier-Zepter, Peter Neuhaus, Alexandra Konradi, Steven Dooley, Christian von Loeffelholz, Matthias Blüher, Andreas F H Pfeiffer, Natalia Rudovich
PubMed ID: 25281430
Date Published: 3rd Oct 2014
Projects: C5: Structural changes and functional consequences of the liver lobular/...
Journal: Diabetes
Citation: Diabetes 64(3): 856-66
Authors: Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter, Stefan Schuster
PubMed ID: 25270362
Date Published: 2nd Oct 2014
Projects: No Projects
Journal: Mol Biosyst
Citation: Mol Biosyst 10(12): 3044-65
Scales: Not specified
Abstract (Expand)
Created: 3rd Dec 2014 at 20:25
Authors: Dirk Drasdo, Stefan Hoehme, Jan G. Hengstler
DOI: 10.1016/j.jhep.2014.06.013
Date Published: 1st Oct 2014
Projects: C: Liver lobule level
Journal: Journal of Hepatology
Citation: Journal of Hepatology 61(4) : 951
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:09  Last updated: 7th Nov 2014 at 15:09
Author: Adriano Henney
DOI: 10.4155/FMC.14.127
Date Published: 1st Oct 2014
Projects: No Projects
Journal: Future Medicinal Chemistry
Citation: Future Medicinal Chemistry 6(16) : 1735
Scales: Not specified
Abstract:
Created: 28th Nov 2014 at 17:48
Authors: Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen, Anja Schroeter
PubMed ID: 25248454
Date Published: 25th Sep 2014
Projects: No Projects
Journal: Mol Biosyst
Citation: Mol Biosyst 10(12): 3066-74
Scales: Not specified
Abstract (Expand)
Created: 3rd Dec 2014 at 20:29
Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach
Authors: T Ricken, D Werner, H G Holzhütter, M König, U Dahmen, O Dirsch
PubMed ID: 25236798
Date Published: 19th Sep 2014
Projects: A1: Cellular metabolism, C: Liver lobule level, E: Model integration
Journal: Biomech Model Mechanobiol
Citation: Biomech Model Mechanobiol 14(3): 515-36
Scales: Cell and Liver lobule
Abstract (Expand)
Created: 30th Jun 2015 at 07:09
Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms
Authors: Andreas Bitter, Petra Rümmele, Kathrin Klein, Benjamin A Kandel, Jessica K Rieger, Andreas K Nüssler, Ulrich M Zanger, Michael Trauner, Matthias Schwab, Oliver Burk
PubMed ID: 25182422
Date Published: 3rd Sep 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G3: Clinical Translation to Pharmaceutical Drug Development, Showcase Steatosis
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. :
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 5th Dec 2014 at 12:44
Authors: Sandra Winkler, Bruno Christ
PubMed ID: 25173373
Date Published: 1st Sep 2014
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Journal: Methods Mol. Biol.
Citation: Methods Mol. Biol. 1213: 51-6
The many faces of Hedgehog signalling in the liver: Recent progress reveals striking cellular diversity and the importance of microenvironments
Authors: Madlen Matz-Soja, Rolf Gebhardt
PubMed ID: 25152210
Date Published: 26th Aug 2014
Scales: Not specified
Abstract:
Created: 1st Dec 2014 at 15:54
On Calculation of the Electrostatic Potential of a Phosphatidylinositol Phosphate-Containing Phosphatidylcholine Lipid Membrane Accounting for Membrane Dynamics
Authors: Jonathan C. Fuller, Michael Martinez, Rebecca C. Wade
DOI: 10.1371/journal.pone.0104778
Date Published: 20th Aug 2014
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 9(8) : e104778
Scales: Cell
Abstract (Expand)
Created: 20th Aug 2014 at 19:55  Last updated: 20th Aug 2014 at 19:57
Foxf1 SiRNA Delivery to Hepatic Stellate Cells by DBTC Lipoplex Formulations Ameliorates Fibrosis in Livers of Bile Duct Ligated Mice
Authors: Kerstin Abshagen, Malte Brensel, Berit Genz, Kira Roth, Maria Thomas, Volker Fehring, Ute Schaeper, Brigitte Vollmar
PubMed ID: 25619889
Date Published: 11th Aug 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Curr Gene Ther
Citation: Curr Gene Ther :
Authors: Christian Tönsing, Jens Timmer, Clemens Kreutz
PubMed ID: 25215847
Date Published: 11th Aug 2014
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., B2.1: Hepatic stellate cells as source and target for hepatocellular gro...
Journal: Phys Rev E Stat Nonlin Soft Matter Phys
Citation: Phys Rev E Stat Nonlin Soft Matter Phys 90(2): 023303
Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload
Authors: Sandro Altamura, Regina Kessler, Hermann-Josef Gröne, Norbert Gretz, Matthias W Hentze, Bruno Galy, Martina U Muckenthaler
PubMed ID: 25100063
Date Published: 8th Aug 2014
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Cell Metab.
Citation: Cell Metab. 20(2): 359-67
Scales: Intercellular, Liver and Organism
Abstract (Expand)
Created: 21st Jan 2015 at 10:21
morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring
Authors: Ines Wagner, Michael Volkmer, Malvika Sharan, Jose M Villaveces, Felix Oswald, Vineeth Surendranath, Bianca H Habermann
PubMed ID: 25096057
Date Published: 6th Aug 2014
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., A3: Crosslinking signalling metabolism and hepatocyte polarisation, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: BMC Bioinformatics
Citation: BMC Bioinformatics 15(1): 263
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:33
Authors: Johannes Eichner, Yvonne Heubach, Manuel Ruff, Hella Kohlhof, Stefan Strobl, Barbara Mayer, Michael Pawlak, Markus F. Templin, Andreas Zell
DOI: 10.1016/j.biosystems.2014.06.009
Date Published: 1st Aug 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Biosystems
Citation: Biosystems 122 : 19
Scales: Cell and Intercellular
Abstract (Expand)
Created: 17th Nov 2015 at 12:14  Last updated: 17th Nov 2015 at 12:15
Authors: L Kuepfer, R Kerb, A M Henney
DOI: 10.1038/psp.2014.25
Date Published: 30th Jul 2014
Projects: G: Clinical translation
Journal: CPT: pharmacomet. syst. pharmacol.
Citation: CPT: pharmacomet. syst. pharmacol. 3(7) : e127
Scales: Organism
Abstract:
Created: 13th Aug 2014 at 19:07  Last updated: 13th Aug 2014 at 19:12
Authors: Rolf Gebhardt, Madlen Matz-Soja
PubMed ID: 25024605
Date Published: 16th Jul 2014
Projects: C3: Zonation of metabolism and its regulation, Virtual Liver
Journal: World J. Gastroenterol.
Citation: World J. Gastroenterol. 20(26): 8491-504
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 26th Jan 2015 at 09:50
Authors: Sandeep Salipalli, Prafull Kumar Singh, Jürgen Borlak
PubMed ID: 25005127
Date Published: 8th Jul 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: BMC Cell Biol.
Citation: BMC Cell Biol. 15(1): 26
Authors: Moritz Kleine, Marc Riemer, Till Krech, Daphne DeTemple, Mark D Jäger, Frank Lehner, Michael P Manns, Jürgen Klempnauer, Jürgen Borlak, Hueseyin Bektas, Florian W R Vondran
PubMed ID: 24999631
Date Published: 7th Jul 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: PLoS ONE
Citation: PLoS ONE 9(7): e101386
Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells
Authors: Berit Genz, Maria Thomas, Brigitte M Pützer, Marcin Siatkowski, Georg Fuellen, Brigitte Vollmar, Kerstin Abshagen
PubMed ID: 24995995
Date Published: 6th Jul 2014
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells
Journal: Exp. Cell Res.
Citation: Exp. Cell Res. :
Authors: Maria Thomas, Jessica K Rieger, Benjamin A Kandel, Kathrin Klein, Ulrich M Zanger
PubMed ID: 25012546
Date Published: 1st Jul 2014
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C: Liver lobule level
Journal: Cell. Physiol. Biochem.
Citation: Cell. Physiol. Biochem. 33(6): 2003-2013
Scales: Not specified
Abstract (Expand)
Created: 14th Jul 2014 at 13:17
A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models
Authors: A. Ryll, J. Bucher, A. Bonin, S. Bongard, E. Gonçalves, J. Saez-Rodriguez, J. Niklas, S. Klamt
DOI: 10.1016/j.biosystems.2014.07.002
Date Published: 1st Jul 2014
Projects: A1: Cellular metabolism, A2.5: Integration of insulin and Wnt signalling in hepatocytes, A2: Integration of Signalling Pathways in Hepatocellular Response, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, Showcase Steatosis, Virtual Liver
Journal: Biosystems
Citation: Biosystems
Scales: Cell
Abstract (Expand)
Created: 6th Aug 2014 at 07:36  Last updated: 6th Aug 2014 at 07:50
Authors: Juliane Liepe, Herman-Georg Holzhütter, Peter M Kloetzel, Michael P H Stumpf, Michele Mishto
PubMed ID: 24970232
Date Published: 28th Jun 2014
Projects: No Projects
Journal: Biomolecules
Citation: Biomolecules 4(2): 585-99
Scales: Not specified
Abstract (Expand)
Created: 6th Jan 2015 at 09:32
A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model
Authors: Minjun Chen, Chun-Wei Tung, Qiang Shi, Lei Guo, Leming Shi, Hong Fang, Jürgen Borlak, Weida Tong
PubMed ID: 24958025
Date Published: 11th Jun 2014
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. 88(7): 1439-49
Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling
Authors: Kristin Dickschen, Thomas Eissing, Thomas Mürdter, Matthias Schwab, Stefan Willmann, Georg Hempel
PubMed ID: 24936398
Date Published: 5th Jun 2014
Projects: G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Springerplus
Citation: Springerplus 3: 285
Scales: Not specified
Abstract (Expand)
Created: 7th Apr 2015 at 14:48
Authors: Minjun Chen, Jürgen Borlak, Weida Tong
PubMed ID: 24857265
Date Published: 27th May 2014
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Expert Rev Gastroenterol Hepatol
Citation: Expert Rev Gastroenterol Hepatol : 1-3
Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6
Authors: Michael H Court, Fawziah E Almutairi, David J Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M Zanger, Joanne Bourgea, Christopher J Patten, Awewura Kwara
PubMed ID: 24820076
Date Published: 12th May 2014
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G: Clinical translation
Journal: Antimicrob. Agents Chemother.
Citation: Antimicrob. Agents Chemother. 58(7): 4145-52
Scales: Not specified
Abstract (Expand)
Created: 8th Dec 2014 at 09:49
Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model
Authors: Sandra Winkler, Erawan Borkham-Kamphorst, Peggy Stock, Sandra Brückner, Matthias Dollinger, Ralf Weiskirchen, Bruno Christ
PubMed ID: 24786317
Date Published: 3rd May 2014
Projects: C4: Disturbance of liver lobule organization in NAFLD, C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase Steatosis
Journal: Exp. Cell Res.
Citation: Exp. Cell Res. :
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
Authors: Seddik Hammad, Stefan Hoehme, Adrian Friebel, Iris von Recklinghausen, Amnah Othman, Brigitte Begher-Tibbe, Raymond Reif, Patricio Godoy, Tim Johann, Amruta Vartak, Klaus Golka, Petru O. Bucur, Eric Vibert, Rosemarie Marchan, Bruno Christ, Steven Dooley, Christoph Meyer, Iryna Ilkavets, Uta Dahmen, Olaf Dirsch, Jan Böttger, Rolf Gebhardt, Dirk Drasdo, Jan G. Hengstler
DOI: 10.1007/s00204-014-1243-5
Date Published: 1st May 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., CTU Confocal microscopy, CTU Image Processing
Journal: Arch Toxicol
Citation: Arch Toxicol 88(5) : 1161
Scales: Liver lobule and Liver
Abstract:
Created: 7th Nov 2014 at 15:11  Last updated: 7th Nov 2014 at 15:11
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
Authors: Freimut Schliess, Stefan Hoehme, Sebastian G. Henkel, Ahmed Ghallab, Dominik Driesch, Jan Böttger, Reinhard Guthke, Michael Pfaff, Jan G. Hengstler, Rolf Gebhardt, Dieter Häussinger, Dirk Drasdo, Sebastian Zellmer
DOI: 10.1002/hep.27136
Date Published: 1st May 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A2.1: Multi-level regulation of signalling pathways important for primin..., A2.4: Linking signalling pathways regulating liver regeneration and orga..., A3.4: Linking signalling to metabolic functions
Journal: Hepatology
Citation: Hepatology : n/a
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:12  Last updated: 7th Nov 2014 at 15:12
Authors: Ulrike Wittig, Renate Kania, Meik Bittkowski, Elina Wetsch, Lei Shi, Lenneke Jong, Martin Golebiewski, Maja Rey, Andreas Weidemann, Isabel Rojas, Wolfgang Müller
DOI: 10.1016/j.pisc.2014.02.004
Date Published: 1st May 2014
Projects: F3: Kinetic data handling
Journal: Perspectives in Science
Citation: Perspectives in Science 1(1-6) : 33
Scales: Not specified
Abstract (Expand)
Created: 3rd Feb 2015 at 10:55  Last updated: 3rd Feb 2015 at 11:03
Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury
Authors: Peggy Stock, Sandra Brückner, Sandra Winkler, Matthias M Dollinger, Bruno Christ
PubMed ID: 24758938
Date Published: 25th Apr 2014
Projects: A1: Cellular metabolism, C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase HGF and Regeneration
Journal: Int J Mol Sci
Citation: Int J Mol Sci 15(4): 7004-28
Scales: Liver lobule and Liver
Abstract (Expand)
Created: 19th May 2014 at 20:04
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity
Authors: Gisela Campos, Wolfgang Schmidt-Heck, Ahmed Ghallab, Katharina Rochlitz, Larissa Pütter, Danilo B Medinas, Claudio Hetz, Agata Widera, Cristina Cadenas, Brigitte Begher-Tibbe, Raymond Reif, Georgia Günther, Agapios Sachinidis, Jan G Hengstler, Patricio Godoy
PubMed ID: 24748426
Date Published: 20th Apr 2014
Projects: C2: Organization of the sinusoidal system and the liver lobule - referen..., C6: Organization and function of the sinusoidal system and the liver lob..., Showcase HGF and Regeneration
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. 88(6): 1267-80
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2015 at 13:25
Authors: Jürgen Borlak, Anil Chougule, Prafull Kumar Singh
PubMed ID: 24685772
Date Published: 2nd Apr 2014
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Toxicol In Vitro
Citation: Toxicol In Vitro :
Authors: Nadine Hohmann, Wei Weiwei, Uta Dahmen, Olaf Dirsch, Andreas Deutsch, Anja Voss-Böhme
DOI: 10.1371/journal.pone.0093207
Date Published: 1st Apr 2014
Scales: Intercellular, Liver lobule and Liver
Abstract (Expand)
Created: 24th Apr 2014 at 14:21  Last updated: 24th Apr 2014 at 14:26
Authors: Blanca Herrera, Steven Dooley, Katja Breitkopf-Heinlein
PubMed ID: 24670474
Date Published: 29th Mar 2014
Projects: A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A3.3: Hepatocyte polarity, B2.1: Hepatic stellate cells as source and target for hepatocellular gro..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., Showcase HGF and Regeneration, Showcase LPS and Inflammation
Journal: Int J Mol Sci
Citation: Int J Mol Sci 15(4): 5199-220
Scales: Not specified
Abstract (Expand)
Created: 31st Mar 2014 at 11:18
Authors: Dagmar Waltemath, Frank T. Bergmann, Claudine Chaouiya, Tobias Czauderna, Padraig Gleeson, Carole Goble, Martin Golebiewski, Michael Hucka, Nick Juty, Olga Krebs, Nicolas Le Novère, Huaiyu Mi, Ion I. Moraru, Chris J. Myers, David Nickerson, Brett G. Olivier, Nicolas Rodriguez, Falk Schreiber, Lucian Smith, Fengkai Zhang, Eric Bonnet
DOI: 10.4056/sigs.5279417
Date Published: 15th Mar 2014
Projects: F1: The data management system
Journal: Stand. Genomic Sci.
Citation: Stand. Genomic Sci. 9(3) : 1285
Scales: Not specified
Abstract (Expand)
Created: 3rd Feb 2015 at 11:07  Last updated: 3rd Feb 2015 at 11:12
Authors: Lars Ole Schwen, Markus Krauss, Christoph Niederalt, Felix Gremse, Fabian Kiessling, Andrea Schenk, Tobias Preusser, Lars Kuepfer
DOI: 10.1371/journal.pcbi.1003499
Date Published: 13th Mar 2014
Projects: D1: Regulation of Blood Flow and Perfusion in the Liver, E3: Horizontal integration on organ scale, E4: Vertical integration across biological scales, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 10(3) : e1003499
Abstract (Expand)
Created: 14th Mar 2014 at 09:13  Last updated: 14th Mar 2014 at 09:28
Authors: Nishika Sahini, Jürgen Borlak
PubMed ID: 24607340
Date Published: 13th Mar 2014
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: Prog. Lipid Res.
Citation: Prog. Lipid Res. 54C: 86-112
Authors: Juan Carlos López Alfonso, Nick Jagiella, Luis Núñez, Miguel A. Herrero, Dirk Drasdo
DOI: 10.1371/journal.pone.0089380
Date Published: 26th Feb 2014
Projects: No Projects
Journal: PLoS ONE
Citation: PLoS ONE 9(2) : e89380
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:14  Last updated: 7th Nov 2014 at 15:14
Authors: Madlen Matz-Soja, Susanne Aleithe, Eugenia Marbach, Jan Böttger, Katrin Arnold, Wolfgang Schmidt-Heck, Jürgen Kratzsch, Rolf Gebhardt
PubMed ID: 24548465
Date Published: 18th Feb 2014
Authors: Minjun Chen, Halil Bisgin, Lillian Tong, Huixiao Hong, Hong Fang, Jürgen Borlak, Weida Tong
PubMed ID: 24521015
Date Published: 14th Feb 2014
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Biomark Med
Citation: Biomark Med 8(2): 201-13
Authors: Jose M Villaveces, Rafael C Jimenez, Bianca H Habermann
PubMed ID: 24715980
Date Published: 13th Feb 2014
Projects: No Projects
Journal: F1000Res
Citation: F1000Res 3: 43
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:29
Authors: Jose M Villaveces, Rafael C Jimenez, Bianca H Habermann
PubMed ID: 25075287
Date Published: 13th Feb 2014
Projects: A1.3: Identification of crucial metabolic processes during hepatocyte pr..., A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.5: The impact of cell polarity on metabolism detoxification and endoc..., A3: Crosslinking signalling metabolism and hepatocyte polarisation, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob...
Journal: F1000Res
Citation: F1000Res 3: 44
Scales: Not specified
Abstract (Expand)
Created: 11th Aug 2014 at 16:31
Authors: J. Starruss, W. d. Back, L. Brusch, A. Deutsch
DOI: 10.1093/bioinformatics/btt772
Date Published: 17th Jan 2014
Projects: A3.3: Hepatocyte polarity, A3: Crosslinking signalling metabolism and hepatocyte polarisation, B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., E2: Integration on the liver lobule scale: Image processing and mathemat..., E3: Horizontal integration on organ scale, E: Model integration, Showcase LIAM (Liver Image Analysis Based Model), Virtual Liver
Journal: Bioinformatics
Citation: Bioinformatics
Scales: Cell, Intercellular and Liver lobule
Abstract (Expand)
Created: 20th Jan 2014 at 15:49  Last updated: 20th Jan 2014 at 16:16
Authors: C Borner, D W Andrews
PubMed ID: 24413197
Date Published: 15th Jan 2014
Projects: No Projects
Journal: Cell Death Differ.
Citation: Cell Death Differ. 21(2): 187-91
Scales: Not specified
Abstract:
Created: 22nd Jan 2014 at 15:13
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways
Authors: Katarzyna Mleczko-Sanecka, Franziska Roche, Ana Rita da Silva, Debora Call, Flavia D'Alessio, Anan Ragab, Philip E Lapinski, Ramesh Ummanni, Ulrike Korf, Christopher Oakes, Georg Damm, Lorenza A D'Alessandro, Ursula Klingmüeller, Philip D King, Michael Boutros, Matthias W Hentze, Martina U Muckenthaler
PubMed ID: 24385536
Date Published: 5th Jan 2014
Projects: A3.4: Linking signalling to metabolic functions, B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Blood
Citation: Blood :
Scales: Cell and Intercellular
Abstract (Expand)
Created: 14th Jan 2014 at 12:06
A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis
Authors: Souhayla El Maadidi, Laura Faletti, Birgit Berg, Christin Wenzl, Katrin Wieland, Zhijian J Chen, Ulrich Maurer, Christoph Borner
PubMed ID: 24391214
Date Published: 3rd Jan 2014
Projects: No Projects
Journal: J. Immunol.
Citation: J. Immunol. 192(3): 1171-83
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:15
A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis
Authors: Guillem Casanovas, Anashua Banerji, Flavia d'Alessio, Martina U Muckenthaler, Stefan Legewie
PubMed ID: 24391488
Date Published: 2nd Jan 2014
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: PLoS Comput. Biol.
Citation: PLoS Comput. Biol. 10(1): e1003421
SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques
Authors: Christian Bölling, Michael Weidlich, Hermann-Georg Holzhütter
DOI: 10.1186/2041-1480-5-S1-S1
Date Published: 2014
Projects: F2: The Liver Knowledge Base (LKB)
Journal: J Biomed Sem
Citation: J Biomed Sem 5(Suppl 1) : S1
Scales: Not specified
Abstract (Expand)
Created: 17th Jun 2014 at 13:09  Last updated: 17th Jun 2014 at 13:13
Authors: Olaf Wolkenhauer, Charles Auffray, Olivier Brass, Jean Clairambault, Andreas Deutsch, Dirk Drasdo, Francesco Gervasio, Luigi Preziosi, Philip Maini, Anna Marciniak-Czochra, Christina Kossow, Lars Kuepfer, Katja Rateitschak, Ignacio Ramis-Conde, Benjamin Ribba, Andreas Schuppert, Rod Smallwood, Georgios Stamatakos, Felix Winter, Helen Byrne
DOI: 10.1186/gm538
Date Published: 2014
Projects: No Projects
Journal: Genome Med
Citation: Genome Med 6(3) : 21
Scales: Not specified
Abstract:
Created: 7th Nov 2014 at 15:10  Last updated: 7th Nov 2014 at 15:10
Authors: Osvaldo Chara, Elly M. Tanaka, Lutz Brusch
DOI: 10.1016/B978-0-12-391498-9.00011-5
Date Published: 2014
Projects: A3.3: Hepatocyte polarity, A3.5: The impact of cell polarity on metabolism detoxification and endoc..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/..., C6: Organization and function of the sinusoidal system and the liver lob..., D4: Regeneration and Liver Size, Showcase LIAM (Liver Image Analysis Based Model)
Book: Mechanisms of Regeneration
Citation: Current Topics in Developmental Biology 108 : 283
Scales: Not specified
Abstract:
Created: 22nd Jan 2015 at 16:09  Last updated: 22nd Jan 2015 at 16:11
TFpredict and SABINE: Sequence-Based Prediction of Structural and Functional Characteristics of Transcription Factors
Authors: Johannes Eichner, Florian Topf, Andreas Dräger, Clemens Wrzodek, Dierk Wanke, Andreas Zell
DOI: 10.1371/journal.pone.0082238
Date Published: 12th Dec 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: PLoS ONE
Citation: PLoS ONE 8(12) : e82238
Scales: Cell and Intercellular
Abstract (Expand)
Created: 17th Nov 2015 at 12:27  Last updated: 17th Nov 2015 at 12:28
Authors: Matthias Jeschke, Stephan Baumgärtner, Stefan Legewie
PubMed ID: 24339758
Date Published: 5th Dec 2013
Projects: A2.4: Linking signalling pathways regulating liver regeneration and orga..., B1.2: Reciprocal effect of cell-cell communication on information proces..., B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: PLoS Comput. Biol.
Citation: PLoS Comput. Biol. 9(12): e1003357
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 16:29
Authors: A Köhn-Luque, W de Back, Y Yamaguchi, K Yoshimura, M A Herrero, T Miura
DOI: 10.1088/1478-3975/10/6/066007
Date Published: 1st Dec 2013
Projects: B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd..., B3: Intercellular communication through cell adhesion, C2: Organization of the sinusoidal system and the liver lobule - referen..., C5: Structural changes and functional consequences of the liver lobular/...
Journal: Phys. Biol.
Citation: Phys. Biol. 10(6) : 066007
Scales: Intercellular
Abstract (Expand)
Created: 24th Jan 2014 at 13:54  Last updated: 24th Jan 2014 at 13:57
Authors: Benjamin A Kandel, Sean Ekins, Kristina Leuner, Wolfgang E Thasler, Christian Harteneck, Ulrich M Zanger
PubMed ID: 24259679
Date Published: 22nd Nov 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: J. Pharmacol. Exp. Ther.
Citation: J. Pharmacol. Exp. Ther. :
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 13:53
Authors: Ulrich M Zanger, Kathrin Klein, Maria Thomas, Jessica K Rieger, Roman Tremmel, Benjamin A Kandel, Marcus Klein, Tarek Magdy
PubMed ID: 24196843
Date Published: 8th Nov 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Clin. Pharmacol. Ther.
Citation: Clin. Pharmacol. Ther. :
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 13:58
A fat option for the pig: Hepatocytic differentiated mesenchymal stem cells for translational research
Authors: Sandra Brückner, Hans-Michael Tautenhahn, Sandra Winkler, Peggy Stock, Matthias Dollinger, Bruno Christ
PubMed ID: 24200501
Date Published: 4th Nov 2013
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., Showcase Steatosis
Journal: Exp. Cell Res.
Citation: Exp. Cell Res. 321(2): 267-75
Authors: Ulrike Wittig, Maja Rey, Renate Kania, Meik Bittkowski, Lei Shi, Martin Golebiewski, Andreas Weidemann, Wolfgang Müller, Isabel Rojas
PubMed ID: 24165050
Date Published: 30th Oct 2013
Scales: Not specified
Abstract (Expand)
Created: 27th Nov 2013 at 13:21
Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease
Authors: Sabrina Krautbauer, Kristina Eisinger, Madeleine Lupke, Josef Wanninger, Petra Ruemmele, Yvonne Hader, Thomas S Weiss, Christa Buechler
PubMed ID: 24161595
Date Published: 22nd Oct 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Exp. Mol. Pathol.
Citation: Exp. Mol. Pathol. 95(3): 330-5
Authors: Shahrouz Ghafoory, Katja Breitkopf-Heinlein, Qi Li, Catharina Scholl, Steven Dooley, Stefan Wölfl
PubMed ID: 24147127
Date Published: 17th Oct 2013
Projects: C5: Structural changes and functional consequences of the liver lobular/..., Showcase HGF and Regeneration
Journal: PLoS ONE
Citation: PLoS ONE 8(10): e78262
Scales: Not specified
Abstract (Expand)
Created: 5th Feb 2014 at 12:26
Phosphorylation of the Smo tail is controlled by membrane localisation and is dispensable for clustering
Authors: A. P. Kupinski, I. Raabe, M. Michel, D. Ail, L. Brusch, T. Weidemann, C. Bokel
DOI: 10.1242/jcs.128926
Date Published: 11th Oct 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Journal of Cell Science
Citation: Journal of Cell Science 126(20) : 4684
Scales: Cell
Abstract (Expand)
Created: 24th Jan 2014 at 14:15  Last updated: 24th Jan 2014 at 14:21
Authors: Georg Damm, Elisa Pfeiffer, Britta Burkhardt, Jan Vermehren, Andreas K. Nüssler, Thomas S. Weiss
DOI: 10.1007/s12072-013-9475-7
Date Published: 1st Oct 2013
Projects: CTU SOP Hepatic stellate cells, human, CTU SOP Human Hepatocytes, CTU SOP Kupffer cells/macrophages, human, CTU SOP Liver sinusoidal endothelial cells, human
Journal: Hepatol Int
Citation: Hepatol Int 7(4) : 951
Scales: Cell
Abstract:
Created: 30th Jan 2014 at 16:52  Last updated: 30th Jan 2014 at 16:54
Authors: Andreas Raue, Marcel Schilling, Julie Bachmann, Andrew Matteson, Max Schelke, Daniel Kaschek, Sabine Hug, Clemens Kreutz, Brian D Harms, Fabian J Theis, Ursula Klingmüller, Jens Timmer
PubMed ID: 24098642
Date Published: 30th Sep 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS ONE
Citation: PLoS ONE 8(9): e74335
Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury
Authors: Jürgen Borlak, Bijon Chatterji, Kishor B Londhe, Paul B Watkins
PubMed ID: 24070255
Date Published: 27th Sep 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, CTU Proteomics
Journal: Genome Med
Citation: Genome Med 5(9): 86
Abstract (Expand)
Created: 22nd Oct 2013 at 11:09  Last updated: 24th Oct 2013 at 16:14
Authors: Serene M L Lee, Celine Schelcher, Maresa Demmel, Maria Hauner, Wolfgang E Thasler
PubMed ID: 24056912
Date Published: 24th Sep 2013
Projects: A: Cellular level, B: Communication of Hepatocytes and Non-Parenchymal Liver Cells, CTUs, Show cases, Virtual Liver
Journal: J Vis Exp
Citation: J Vis Exp (79):
Authors: Tarek Magdy, Rudolf Arlanov, Stefan Winter, Thomas Lang, Kathrin Klein, Yu Toyoda, Toshihisa Ishikawa, Matthias Schwab, Ulrich M Zanger
PubMed ID: 24024896
Date Published: 13th Sep 2013
Projects: A3.4: Linking signalling to metabolic functions, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Pharmacogenomics
Citation: Pharmacogenomics 14(12): 1433-48
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:01
Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis
Authors: Nikolaus Berndt, Herrmann-Georg Holzhütter, Sascha Bulik
PubMed ID: 23937586
Date Published: 12th Sep 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: FEBS J.
Citation: FEBS J. 280(20): 5080-93
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 10:41
Authors: Stefan Schuster, Heiko Stark
PubMed ID: 24021886
Date Published: 8th Sep 2013
Projects: C3: Zonation of metabolism and its regulation
Journal: Biochim. Biophys. Acta
Citation: Biochim. Biophys. Acta 1840(1): 271-6
Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs
Authors: Ioannis N Melas, Regina Samaga, Leonidas G Alexopoulos, Steffen Klamt
PubMed ID: 24039561
Date Published: 5th Sep 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg...
Journal: PLoS Comput. Biol.
Citation: PLoS Comput. Biol. 9(9): e1003204
A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease
Authors: J Schleicher, R Guthke, U Dahmen, O Dirsch, H G Holzhuetter, S Schuster
PubMed ID: 23999488
Date Published: 4th Sep 2013
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Biochim. Biophys. Acta
Citation: Biochim. Biophys. Acta 1841(1): 62-69
Scales: Cell
Abstract (Expand)
Created: 23rd Oct 2013 at 14:55  Last updated: 24th Oct 2013 at 16:14
Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs
Authors: Minjun Chen, Huixiao Hong, Hong Fang, Reagan Kelly, Guangxu Zhou, Jürgen Borlak, Weida Tong
PubMed ID: 23997115
Date Published: 31st Aug 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Toxicol. Sci.
Citation: Toxicol. Sci. 136(1): 242-9
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Authors: Patricio Godoy, Nicola J Hewitt, Ute Albrecht, Melvin E Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A Budinsky, Britta Burkhardt, Neil R Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E P Goldring, María José Gómez-Lechón, Geny M M Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M Kelm, B Kevin Park, Claus Kordes, Gerd A Kullak-Ublick, Edward L LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J Naisbitt, Andreas K Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H K Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S Weiss, Agata Widera, Courtney G Woods, Jinghai James Xu, Kathy M Yarborough, Jan G Hengstler
PubMed ID: 23974980
Date Published: 23rd Aug 2013
Projects: CTU SOP Human Hepatocytes, CTU SOP Monolayer/sandwich culture hepatocytes, CTU SOP Mouse Hepatocytes, Virtual Liver
Journal: Arch. Toxicol.
Citation: Arch. Toxicol. 87(8): 1315-530
Scales: Not specified
Abstract (Expand)
Created: 9th Sep 2013 at 15:23  Last updated: 24th Oct 2013 at 16:14
Comparative analysis of TGF-beta/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines
Authors: J. Dzieran, J. Fabian, T. Feng, C. Coulouarn, I. Ilkavets, A. Kyselova, K. Breuhahn, S. Dooley, N. M. Meindl-Beinker
PubMed ID: 23991075
Date Published: 22nd Aug 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: PLoS One
Citation: PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252. eCollection 2013.
Scales: Not specified
Abstract (Expand)
Created: 27th Jul 2015 at 07:19
Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test
Authors: Hermann-Georg Holzhütter, Johan Friso Lock, Pouria Taheri, Sascha Bulik, Andrean Goede, Martin Stockmann
PubMed ID: 23967104
Date Published: 15th Aug 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, E4: Vertical integration across biological scales
Journal: PLoS ONE
Citation: PLoS ONE 8(8): e70780
Scales: Not specified
Abstract (Expand)
Created: 9th Sep 2013 at 15:13  Last updated: 24th Oct 2013 at 16:14
Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse
Authors: Roman Liebe, Rabea A Hall, Robert W Williams, Steven Dooley, Frank Lammert
PubMed ID: 23943854
Date Published: 13th Aug 2013
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., A2.2: Regulation of pro-apoptotic and anti-apoptotic responses in hepato..., Showcase LPS and Inflammation
Journal: Physiol. Genomics
Citation: Physiol. Genomics 45(20): 931-9
Scales: Not specified
Abstract (Expand)
Created: 6th Dec 2013 at 09:19
Authors: Andrea U Steinbicker, Martina U Muckenthaler
PubMed ID: 23917168
Date Published: 7th Aug 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Nutrients
Citation: Nutrients 5(8): 3034-61
Scales: Cell, Intercellular and Organism
Abstract (Expand)
Created: 20th Jan 2014 at 11:06
Authors: Sabrina Krautbauer, Josef Wanninger, Kristina Eisinger, Yvonne Hader, Michael Beck, Andrea Kopp, Andreas Schmid, Thomas S Weiss, Christoph Dorn, Christa Buechler
PubMed ID: 23906870
Date Published: 29th Jul 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.6: Transcription factor network and links to metabolism in NAFLD, CTU SOP Human Hepatocytes, Show cases
Journal: Exp. Mol. Pathol.
Citation: Exp. Mol. Pathol. 95(2): 199-205
Authors: Marc Hovestädt, Ulrike Kuckelkorn, Agathe Niewienda, Christin Keller, Andrean Goede, Bernhard Ay, Stefan Günther, Katharina Janek, Rudolf Volkmer, Hermann-Georg Holzhütter
PubMed ID: 23893543
Date Published: 28th Jul 2013
Projects: No Projects
Journal: J. Pept. Sci.
Citation: J. Pept. Sci. 19(9): 588-97
Scales: Not specified
Abstract (Expand)
Created: 9th Sep 2013 at 15:19  Last updated: 24th Oct 2013 at 16:14
DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome
Authors: Pascale Fisel, Stephan Kruck, Stefan Winter, Jens Bedke, Jörg Hennenlotter, Anne T Nies, Marcus Scharpf, Falko Fend, Arnulf Stenzl, Matthias Schwab, Elke Schaeffeler
PubMed ID: 23881922
Date Published: 23rd Jul 2013
Projects: B5: Cell-cell communication influences detoxifying functions in hepatocytes, G3: Clinical Translation to Pharmaceutical Drug Development
Journal: Clin. Cancer Res.
Citation: Clin. Cancer Res. 19(18): 5170-81
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 14:16
Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration
Authors: Rania Dayoub, Arndt Vogel, Jutta Schuett, Madeleine Lupke, Susannah M Spieker, Nadja Kettern, Eberhard Hildt, Michael Melter, Thomas S Weiss
PubMed ID: 23887691
Date Published: 23rd Jul 2013
Projects: A2.1: Multi-level regulation of signalling pathways important for primin..., CTU SOP Human Hepatocytes
Journal: Mol. Med.
Citation: Mol. Med. 19: 237-44
Evaluation of 41 candidate gene variants for obesity in the EPIC-potsdam cohort by multi-locus stepwise regression
Authors: Sven Knüppel, Klaus Rohde, Karina Meidtner, Dagmar Drogan, Hermann-Georg Holzhütter, Heiner Boeing, Eva Fisher
PubMed ID: 23874820
Date Published: 12th Jul 2013
Projects: No Projects
Journal: PLoS ONE
Citation: PLoS ONE 8(7): e68941
Scales: Not specified
Abstract (Expand)
Created: 20th Jan 2014 at 10:28
Authors: A Geissler, F Haun, D O Frank, K Wieland, M M Simon, M Idzko, R J Davis, U Maurer, C Borner
PubMed ID: 23832115
Date Published: 5th Jul 2013
Projects: No Projects
Journal: Cell Death Differ.
Citation: Cell Death Differ. 20(10): 1317-29
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:18
GRN2SBML: Automated encoding and annotation of inferred gene regulatory networks complying with SBML
Authors: S. Vlaic, B. Hoffmann, P. Kupfer, M. Weber, A. Drager
DOI: 10.1093/bioinformatics/btt370
Date Published: 26th Jun 2013
Projects: A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: Bioinformatics
Citation: Bioinformatics 29(17) : 2216
Scales: Cell
Abstract (Expand)
Created: 1st Jul 2013 at 23:57  Last updated: 24th Oct 2013 at 16:14
Authors: Regina Samaga, Steffen Klamt
PubMed ID: 23803171
Date Published: 26th Jun 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg...
Journal: Cell Commun. Signal
Citation: Cell Commun. Signal 11(1): 43
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape
Authors: Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin Maier, Marino Zerial
PubMed ID: 23792630
Date Published: 23rd Jun 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: Nat. Biotechnol.
Citation: Nat. Biotechnol. 31(7): 638-46
Scales: Cell, Intercellular and Liver
Abstract (Expand)
Created: 15th Jul 2013 at 11:10  Last updated: 24th Oct 2013 at 16:14
Authors: André Homeyer, Andrea Schenk, Janine Arlt, Uta Dahmen, Olaf Dirsch, Horst K Hahn
PubMed ID: 23796718
Date Published: 21st Jun 2013
Projects: CTU Image Processing, D4: Regeneration and Liver Size
Journal: Comput Med Imaging Graph
Citation: Comput Med Imaging Graph 37(4): 313-22
Scales: Liver lobule and Liver
Abstract (Expand)
Created: 7th Nov 2013 at 08:56
TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation
Authors: Jisen Huai, F-Nora Vögtle, Lars Jöckel, Yunbo Li, Thomas Kiefer, Jean-Ehrland Ricci, Christoph Borner
PubMed ID: 23788428
Date Published: 20th Jun 2013
Projects: No Projects
Journal: J. Cell. Sci.
Citation: J. Cell. Sci. 126(Pt 17): 4015-25
Scales: Not specified
Abstract (Expand)
Created: 22nd Jan 2014 at 15:18
Isolation and hepatocyte differentiation of mesenchymal stem cells from porcine bone marrow--"surgical waste" as a novel MSC source
Authors: S Brückner, H-M Tautenhahn, S Winkler, P Stock, S Jonas, M Dollinger, B Christ
PubMed ID: 23769107
Date Published: 19th Jun 2013
Projects: C6: Organization and function of the sinusoidal system and the liver lob..., G: Clinical translation, Showcase Steatosis
Journal: Transplant. Proc.
Citation: Transplant. Proc. 45(5): 2056-8
Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression
Authors: Jessica K Rieger, Kathrin Klein, Stefan Winter, Ulrich M Zanger
PubMed ID: 23733276
Date Published: 3rd Jun 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Drug Metab. Dispos.
Citation: Drug Metab. Dispos. 41(10): 1752-62
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:05
Authors: Anne Gaebler, Robin Milan, Leon Straub, Dominik Hoelper, Lars Kuerschner, Christoph Thiele
PubMed ID: 23709689
Date Published: 23rd May 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: J. Lipid Res.
Citation: J. Lipid Res. 54(8): 2282-90
Scales: Not specified
Abstract (Expand)
Created: 6th Jan 2014 at 11:19
Authors: Clemens Kreutz, Andreas Raue, Daniel Kaschek, Jens Timmer
PubMed ID: 23581573
Date Published: 9th May 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato...
Journal: FEBS J.
Citation: FEBS J. 280(11): 2564-71
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 11:37
Metabolic Gradients as Key Regulators in Zonation of Tumor Energy Metabolism: A Tissue-scale Model Based Study
Authors: Matthias König, Hermann-Georg Holzhütter, Nikolaus Berndt
PubMed ID: 23589477
Date Published: 17th Apr 2013
Projects: C3: Zonation of metabolism and its regulation
Journal: Biotechnol J
Citation: Biotechnol J 8(9): 1058-69
Scales: Not specified
Abstract (Expand)
Created: 6th May 2013 at 09:31  Last updated: 24th Oct 2013 at 16:14
Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists
Authors: L. Shi, L. Jong, U. Wittig, P. Lucarelli, M. Stepath, S. Mueller, L. A. D'Alessandro, U. Klingmuller, W. Muller
PubMed ID: 23549603
Date Published: 3rd Apr 2013
Projects: F1: The data management system
Journal: J Integr Bioinform
Citation: J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.
Scales: Not specified
Abstract (Expand)
Created: 7th Aug 2015 at 12:16
Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Authors: Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha, Julio Saez-Rodriguez
PubMed ID: 23525368
Date Published: 26th Mar 2013
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, A: Cellular level, E: Model integration, Virtual Liver
Journal: Mol Biosyst
Citation: Mol Biosyst 9(7): 1576-83
Scales: Cell, Liver and Organism
Abstract (Expand)
Created: 3rd Jun 2013 at 16:37  Last updated: 24th Oct 2013 at 16:14
Authors: Philip Stegmaier, Alexander Kel, Edgar Wingender, Jürgen Borlak
DOI: 10.1371/journal.pcbi.1002958
Date Published: 21st Mar 2013
Projects: A3.6: Transcription factor network and links to metabolism in NAFLD
Journal: PLoS Comput Biol
Citation: PLoS Comput Biol 9(3) : e1002958
Scales: Cell
Abstract (Expand)
Created: 28th Mar 2013 at 11:59  Last updated: 24th Oct 2013 at 16:14
Authors: Bruno Galy, Dunja Ferring-Appel, Christiane Becker, Norbert Gretz, Hermann-Josef Gröne, Klaus Schümann, Matthias W Hentze
PubMed ID: 23523353
Date Published: 21st Mar 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Cell Rep
Citation: Cell Rep 3(3): 844-57
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 14:38
Authors: Jonathan C Fuller, Pierre Khoueiry, Holger Dinkel, Kristoffer Forslund, Alexandros Stamatakis, Joseph Barry, Aidan Budd, Theodoros G Soldatos, Katja Linssen, Abdul Mateen Rajput
Date Published: 15th Mar 2013
Scales: Not specified
Abstract (Expand)
Created: 13th Jan 2014 at 15:08  Last updated: 13th Jan 2014 at 15:14
Authors: Nikolaus Berndt, Hermann-Georg Holzhütter
PubMed ID: 23479331
Date Published: 13th Mar 2013
Projects: No Projects
Journal: Cell Biochem. Biophys.
Citation: Cell Biochem Biophys. 67(2):527-35
Scales: Not specified
Abstract (Expand)
Created: 6th May 2013 at 09:24  Last updated: 24th Oct 2013 at 16:14
Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools
Authors: Robert Radloff, Alain Gras, Ulrich M Zanger, Cécile Masquelier, Karthik Arumugam, Jean-Claude Karasi, Vic Arendt, Carole Seguin-Devaux, Kathrin Klein
PubMed ID: 23418033
Date Published: 11th Mar 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Hum. Mutat.
Citation: Hum. Mutat. 34(5): 725-34
Scales: Not specified
Abstract (Expand)
Created: 13th Jan 2014 at 10:17
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Authors: Ulrich M Zanger, Kathrin Klein
PubMed ID: 23467454
Date Published: 5th Mar 2013
Projects: A3.4: Linking signalling to metabolic functions
Journal: Front Genet
Citation: Front Genet 4: 24
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:10
Authors: Ines Thiele, Neil Swainston, Ronan M T Fleming, Andreas Hoppe, Swagatika Sahoo, Maike K Aurich, Hulda Haraldsdottir, Monica L Mo, Ottar Rolfsson, Miranda D Stobbe, Stefan G Thorleifsson, Rasmus Agren, Christian Bölling, Sergio Bordel, Arvind K Chavali, Paul Dobson, Warwick B Dunn, Lukas Endler, David Hala, Michael Hucka, Duncan Hull, Daniel Jameson, Neema Jamshidi, Jon J Jonsson, Nick Juty, Sarah Keating, Intawat Nookaew, Nicolas Le Novère, Naglis Malys, Alexander Mazein, Jason A Papin, Nathan D Price, Evgeni Selkov, Martin I Sigurdsson, Evangelos Simeonidis, Nikolaus Sonnenschein, Kieran Smallbone, Anatoly Sorokin, Johannes H G M van Beek, Dieter Weichart, Igor Goryanin, Jens Nielsen, Hans V Westerhoff, Douglas B Kell, Pedro Mendes, Bernhard Ø Palsson
PubMed ID: 23455439
Date Published: 3rd Mar 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A1.3: Identification of crucial metabolic processes during hepatocyte pr...
Journal: Nat. Biotechnol.
Citation: Nat. Biotechnol. 31(5): 419-25
Scales: Not specified
Abstract (Expand)
Created: 19th Mar 2013 at 12:53  Last updated: 24th Oct 2013 at 16:15
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
Authors: D Casarrubea, L Viatte, T Hallas, A Vasanthakumar, R S Eisenstein, K Schümann, M W Hentze, B Galy
PubMed ID: 23455710
Date Published: 1st Mar 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: J. Mol. Med.
Citation: J. Mol. Med. 91(7): 871-81
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 14:40
Differently Saturated Fatty Acids Can Be Differentiated by (31)P NMR Subsequent to Derivatization with 2-Chloro-4,4,5,5-tetramethyldioxaphospholane: A Cautionary Note
Authors: Mandy Eibisch, Thomas Riemer, Beate Fuchs, Jürgen Schiller
PubMed ID: 23414224
Date Published: 26th Feb 2013
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Journal: J. Agric. Food Chem.
Citation: J. Agric. Food Chem. 61(11): 2696-700
Scales: Not specified
Abstract (Expand)
Created: 6th Jan 2014 at 13:54
Authors: Kathrin Klein, Ulrich M Zanger
PubMed ID: 23444277
Date Published: 25th Feb 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: Front Genet
Citation: Front Genet 4: 12
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:16
Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation
Authors: Madlen Matz-Soja, Amalya Hovhannisyan, Rolf Gebhardt
PubMed ID: 23433827
Date Published: 21st Feb 2013
Authors: Alfredo Castello, Bernd Fischer, Matthias W Hentze, Thomas Preiss
PubMed ID: 23415593
Date Published: 15th Feb 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Trends Genet.
Citation: Trends Genet. 29(5): 318-27
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 14:42
Authors: Alfredo Castello, Rastislav Horos, Claudia Strein, Bernd Fischer, Katrin Eichelbaum, Lars M Steinmetz, Jeroen Krijgsveld, Matthias W Hentze
PubMed ID: 23411631
Date Published: 14th Feb 2013
Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...
Journal: Nat Protoc
Citation: Nat Protoc 8(3): 491-500
Scales: Not specified
Abstract (Expand)
Created: 14th Jan 2014 at 14:41
A Unifying Ontology to Integrate Histological and Clinical Observations for Drug-Induced Liver Injury
Authors: Yuping Wang, Zhi Lin, Zhichao Liu, Stephen Harris, Reagan Kelly, Jie Zhang, Weigong Ge, Minjun Chen, Jürgen Borlak, Weida Tong
PubMed ID: 23395088
Date Published: 12th Feb 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Am. J. Pathol.
Citation: Am. J. Pathol. 182(4): 1180-7
Scales: Liver
Abstract (Expand)
Created: 5th Mar 2013 at 16:36  Last updated: 24th Oct 2013 at 16:15
Authors: M Chen, J Zhang, Y Wang, Z Liu, R Kelly, G Zhou, H Fang, J Borlak, W Tong
PubMed ID: 23486446
Date Published: 25th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions
Journal: Clin. Pharmacol. Ther.
Citation: Clin. Pharmacol. Ther. 93(5): 409-12
Scales: Cell
Abstract:
Created: 15th Mar 2013 at 14:16  Last updated: 24th Oct 2013 at 16:15
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
Authors: Juan G Diaz Ochoa, Joachim Bucher, Alexandre R R Péry, José M Zaldivar Comenges, Jens Niklas, Klaus Mauch
PubMed ID: 23346056
Date Published: 22nd Jan 2013
Projects: No Projects
Journal: Front Pharmacol
Citation: Front Pharmacol 3: 204
Scales: Not specified
Abstract (Expand)
Created: 4th Feb 2013 at 11:46  Last updated: 24th Oct 2013 at 16:15
Authors: Adviti Naik, Aleš Belič, Ulrich M Zanger, Damjana Rozman
PubMed ID: 23346097
Date Published: 22nd Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, A3.6: Transcription factor network and links to metabolism in NAFLD, G1: Clinical Translation to Invasively Characterized Patients, Showcase Steatosis
Journal: Front Genet
Citation: Front Genet 4: 2
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:35
Authors: C Meyer, Y Liu, A Kaul, I Peipe, S Dooley
PubMed ID: 23328673
Date Published: 19th Jan 2013
Projects: A3.2: Cross-talk of signaling pathways and endocytic machinery in hepato..., A3.3: Hepatocyte polarity
Journal: Cell Death Dis
Citation: Cell Death Dis 4: e466
Scales: Cell
Abstract (Expand)
Created: 23rd Jan 2013 at 17:53  Last updated: 24th Oct 2013 at 16:15
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Authors: Ulrich M Zanger, Matthias Schwab
PubMed ID: 23333322
Date Published: 16th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Pharmacol. Ther.
Citation: Pharmacol. Ther. 138(1): 103-41
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2014 at 14:40
Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
Authors: Anne T Nies, Mikko Niemi, Oliver Burk, Stefan Winter, Ulrich M Zanger, Bruno Stieger, Matthias Schwab, Elke Schaeffeler
PubMed ID: 23311897
Date Published: 11th Jan 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Genome Med
Citation: Genome Med 5(1): 1
Scales: Not specified
Abstract (Expand)
Created: 16th Jan 2013 at 09:16  Last updated: 24th Oct 2013 at 16:15
Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα)
Authors: Maria Thomas, Oliver Burk, Britta Klumpp, Benjamin A Kandel, Georg Damm, Thomas S Weiss, Kathrin Klein, Matthias Schwab, Ulrich M Zanger
PubMed ID: 23295386
Date Published: 9th Jan 2013
Projects: A1.2: Detoxification in hepatocytes challenged by steatotic conditions, A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes, G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, Showcase Steatosis
Journal: Mol. Pharmacol.
Citation: Mol. Pharmacol. 83(3): 709-18
Scales: Cell
Abstract (Expand)
Created: 9th Jan 2013 at 15:04  Last updated: 24th Oct 2013 at 16:15
Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells
Authors: Qi Li, Xing Gu, Honglei Weng, Shahrouz Ghafoory, Yan Liu, Teng Feng, Johanna Dzieran, Li Li, Iryna Ilkavets, Marianna Kruithof-de Julio, Stefan Munker, Alexander Marx, Albrecht Piiper, Eduardo Augusto Alonso, Norbert Gretz, Chunfang Gao, Stefan Wölfl, Steven Dooley, Katja Breitkopf-Heinlein
PubMed ID: 23281849
Date Published: 4th Jan 2013
Projects: A2.3: Cross-talk and distinct properties of growth factor signalling reg..., A3.3: Hepatocyte polarity, B2.1: Hepatic stellate cells as source and target for hepatocellular gro..., B2.3: Effect of hepatic stellate cells on hepatocyte polarity and transd...
Journal: Cancer Sci.
Citation: Cancer Sci. 104(3): 398-408
Scales: Cell
Abstract (Expand)
Created: 18th Jan 2013 at 10:41  Last updated: 24th Oct 2013 at 16:15
Authors: Arian Emami Riedmaier, Pascale Fisel, Anne T Nies, Elke Schaeffeler, Matthias Schwab
PubMed ID: 23277337
Date Published: 2nd Jan 2013
Projects: G1: Clinical Translation to Invasively Characterized Patients, G2: Clinical Translation to Non-Invasive Volunteer Setting, G3: Clinical Translation to Pharmaceutical Drug Development, G4: Whole-Body Detoxification in Mouse Models
Journal: Trends Pharmacol. Sci.
Citation: Trends Pharmacol. Sci. 34(2): 126-35
Scales: Not specified
Abstract (Expand)
Created: 8th Jan 2013 at 10:08  Last updated: 24th Oct 2013 at 16:15
Authors: Christoph Meyer, Johanna Dzieran, Yan Liu, Felizitas Schindler, Stefan Munker, Alexandra Müller, Cédric Coulouarn, Steven Dooley
Date Published: 2013
Projects: A3.3: Hepatocyte polarity
Journal: Cell Commun Signal
Citation: Cell Commun Signal 11(1) : 6
Scales: Cell
Abstract:
Created: 23rd Jan 2013 at 17:57  Last updated: 24th Oct 2013 at 16:15
Authors: J Lippert, M Brosch, O von Kampen, M Meyer, H.-U Siegmund, C Schafmayer, T Becker, B Laffert, L Goerlitz, S Schreiber, PJ Neuvonen, M Niemi, J Hampe, L Kuepfer
DOI: 10.1038/psp.2012.22
Date Published: 2013
Projects: G3: Clinical Translation to Pharmaceutical Drug Development, G: Clinical translation
Journal: CPT: pharmacomet. syst. pharmacol.
Citation: CPT: pharmacomet. syst. pharmacol. 2(1) : e21
Scales: Not specified
Abstract:
Created: 28th Jan 2013 at 09:55  Last updated: 24th Oct 2013 at 16:15
Authors: Clemens Wrzodek, Finja Büchel, Manuel Ruff, Andreas Dräger, Andreas Zell
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 7(1) : 15
Scales: Cell and Intercellular
Abstract (Expand)
Created: 23rd Feb 2013 at 23:19  Last updated: 24th Oct 2013 at 16:15
Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
Authors: Uwe Benary, Bente Kofahl, Andreas Hecht, Jana Wolf
Date Published: 2013
Projects: A2.5: Integration of insulin and Wnt signalling in hepatocytes, B2.2: Importance of Wnt- and Hedgehog factors for hepatic stellate cells...
Journal: Front. Physiol.
Citation: Front. Physiol. 4
Scales: Cell
Abstract (Expand)
Created: 27th Feb 2013 at 10:06  Last updated: 24th Oct 2013 at 16:15
Authors: Roland Keller, Alexander Dörr, Akito Tabira, Akira Funahashi, Michael J Ziller, Richard Adams, Nicolas Rodriguez, Nicolas Le Novère, Noriko Hiroi, Hannes Planatscher, Andreas Zell, Andreas Dräger
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 7(1) : 55
Scales: Cell, Intercellular, Liver lobule, Liver and Organism
Abstract (Expand)
Created: 9th Jul 2013 at 04:12  Last updated: 24th Oct 2013 at 16:15
Authors: Andreas Dräger, Hannes Planatscher
DOI: 10.1007/978-1-4419-9863-7_1277
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Book: Encyclopedia of Systems Biology
Citation: Encyclopedia of Systems Biology : 1249
Scales: Cell
Abstract (Expand)
Created: 15th Aug 2013 at 23:34  Last updated: 23rd Jul 2015 at 13:38
Authors: Andreas Dräger, Hannes Planatscher
DOI: 10.1007/978-1-4419-9863-7_1174
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Book: Encyclopedia of Systems Biology
Citation: Encyclopedia of Systems Biology : 1627
Scales: Cell
Abstract (Expand)
Created: 15th Aug 2013 at 23:37  Last updated: 23rd Jul 2015 at 13:38
Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification
Authors: Markus Krauss, Rolf Burghaus, Jörg Lippert, Mikko Niemi, Pertti Neuvonen, Andreas Schuppert, Stefan Willmann, Lars Kuepfer, Linus Görlitz
Date Published: 2013
Projects: G: Clinical translation
Journal: In Silico Pharmacol
Citation: In Silico Pharmacol 1(1) : 6
Abstract (Expand)
Created: 16th Sep 2013 at 13:50  Last updated: 24th Oct 2013 at 16:15
Authors: Finja Büchel, Nicolas Rodriguez, Neil Swainston, Clemens Wrzodek, Tobias Czauderna, Roland Keller, Florian Mittag, Michael Schubert, Mihai Glont, Martin Golebiewski, Martijn van Iersel, Sarah Keating, Matthias Rall, Michael Wybrow, Henning Hermjakob, Michael Hucka, Douglas B Kell, Wolfgang Müller, Pedro Mendes, Andreas Zell, Claudine Chaouiya, Julio Saez-Rodriguez, Falk Schreiber, Camille Laibe, Andreas Dräger, Nicolas Le Novère
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 7(1) : 116
Scales: Cell and Intercellular
Abstract (Expand)
Created: 4th Nov 2013 at 16:48  Last updated: 4th Nov 2013 at 16:54
SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools
Authors: Claudine Chaouiya, Duncan Berenguier, Sarah M Keating, Aurelien Naldi, Martijn P van Iersel, Nicolas Rodriguez, Andreas Dräger, Finja Büchel, Thomas Cokelaer, Bryan Kowal, Benjamin Wicks, Emanuel Gonçalves, Julien Dorier, Michel Page, Pedro T Monteiro, Axel von Kamp, Ioannis Xenarios, Hidde de Jong, Michael Hucka, Steffen Klamt, Denis Thieffry, Nicolas Le Novère, Julio Saez-Rodriguez, Tomá¿ Helikar
Date Published: 2013
Projects: A3.4: Linking signalling to metabolic functions, B5: Cell-cell communication influences detoxifying functions in hepatocytes
Journal: BMC Syst Biol
Citation: BMC Syst Biol 7(1) : 135
Scales: Cell and Intercellular
Abstract (Expand)
Created: 10th Dec 2013 at 18:07  Last updated: 10th Dec 2013 at 18:09