Ppt Non-Alcoholic Steatohepatitis (NASH) in immunodeficient mice: A model for xenogenic stem cell transplantation

Uploader: Bruno Christ

Contributor: Bruno Christ, Sandra Brückner

Other contributors: Not specified

Scales: Liver lobule

Question: NASH is a benign liver disease and will progress, if untreated, into fibrosis/cirrhosis and potentially into hepatocellular cancer. Human cell therapy approaches for the treatment of NASH have not been addressed yet. Therefore, the present work aimed at establishing an animal model to evaluate the feasibility of stem cell-derived hepatocytes in NASH.

Methods: Immundeficient Pfp/Rag2-/- mice were fed with a methionine-choline-deficient diet (MCD diet) for up to 5 weeks. Alanine-aminotransferase

Created: 27th Jul 2012 at 14:25   Last updated: 27th Jul 2012 at 14:43

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