Pdf Mid-Term Evaluation Introduction

Uploader: Adriano M. Henney

Contributor: Adriano M. Henney

Other contributors: Not specified

Version: 1

Projects: No Projects

Scales: Not specified

No description specified

Created: 28th Jan 2013 at 15:39


Ppt MidtermReview Poster Projekt A3.1

Uploader: Sascha Bulik

Contributor: Hermann-Georg Holzhütter, Matthias König, Nikolaus Berndt, Sascha Bulik

Other contributors: Not specified

Scales: Cell

MidtermReview Poster Projekt A3.1

Created: 29th Jan 2013 at 15:12   Last updated: 12th Feb 2013 at 12:07


Ppt MidtermReview Poster Projekt E1

Uploader: Sascha Bulik

Contributor: Andreas Hoppe, Andreas Raue, Carsten Conradi, Christian Bölling, Clemens Kreutz, Daniel Kaschek, Hermann-Georg Holzhütter, Jens Timmer, Jeremy Huard, Katharina Waldow, Katrin Kolczyk, Lorenza D'Alessandro, Matthias König, Nikolaus Berndt, René Meyer, Sascha Bulik, Seong-Hwan Rho, Steffen Klamt, Stephanie Müller, Svantje Braun, Thomas Maiwald, Ursula Klingmüller, Ursula Kummer

Other contributors: Ralph Gauges

Scales: Not specified

MidtermReview Poster Projekt E1

Created: 29th Jan 2013 at 15:11   Last updated: 12th Feb 2013 at 12:13


Pdf Modeling and simulating the effects of atorvastatin on the central carbon metabolism of rat hepatocytes using SBMLsimulator

Uploader: Stephanie Hoffmann

Contributor: Andreas Dräger, Andreas Zell, Benjamin Kandel, Klaus Mauch, Marcus Klein, Maria Thomas, Roland Keller, Stephanie Hoffmann, Ulrich Zanger, Ute Hofmann

Other contributors: Klaus Maier

Scales: Cell

The cholesterol lowering drug atorvastatin (Lipitor) acts by inhibiting the enzyme HMGCoA reductase, which plays a central role in the production of cholesterol in the liver. To investigate the effects of atorvastatin on the central carbon metabolism and the bile acid synthesis we used rat hepatocyte as a model system and constructed a corresponding model based on HepatoNet1 and literature knowledge, e.g. the KEGG knowledgebase. To gain a high-quality model we fully balanced the model and checked

Created: 10th Jul 2012 at 09:54   Last updated: 17th Jul 2012 at 16:04


Pdf Modeling Flow Through Realistic, Algorithmically Generated Vascular Structures in the Liver

Uploader: Lars Ole Schwen

Contributor: Lars Ole Schwen

Other contributors: Not specified

Scales: Liver

Presentation at 21st International Symposium on Mathematical Programming (ISMP 2012)

Created: 27th Aug 2012 at 12:19


Ppt Modelling liver regeneration after hepatocyte transplantation

Uploader: Bruno Christ

Contributor: Bruno Christ, Jan Georg Hengstler, Sandra Brückner, Seddik Hammad

Other contributors: Not specified

Scales: Liver lobule

Question: Liver regeneration is accomplished by the hepatocytes, which restore the liver mass after resection, trauma or toxic exposition provided that the insult does not affect the mitotic response of the hepatocytes. Parenchymal proliferation gives rise to progeny, which take over functional capacity. Yet, only limited knowledge is available on the time-dependent positional impact of regenerating hepatocytes ultimately determing the metabolic power of the liver as a whole. Therefore, it is

Created: 27th Jul 2012 at 14:13   Last updated: 27th Jul 2012 at 14:45


Pdf Moving Towards a Unified Protein Interaction Network

Uploader: Jose Villaveces

Contributor: Bianca Habermann, Jose Villaveces

Other contributors: Rafael C. Jimenez

Scales: Not specified

The analysis of biological networks for interpreting data is becoming a standard in bioinformatics as it enables us to look at a process from the perspective of pathways and network modules rather than single proteins. To study proteins in the context of a cellular system, it is essential that the molecules with which a protein interacts are identified and the functional consequence of each interaction is understood.
We work on several aspects concerning data integration in protein interaction

Created: 30th Oct 2013 at 10:07   Last updated: 30th Oct 2013 at 10:21


Zip Multi-Scale Simulation of Heterogeneous Metabolism in Mammalian Livers

Uploader: Lars Ole Schwen

Contributor: Lars Ole Schwen

Other contributors: Felix Gremse, Markus Krauss, Christoph Niederalt

Scales: Cell, Liver lobule, Liver and Organism

Talk at Jena Centre for Bioinformatics, 2014-11-20

Created: 25th Nov 2014 at 17:37


Pdf Multi-Scale Simulation of Zonated Liver Metabolism

Uploader: Lars Ole Schwen

Contributor: Ahmed Ghallab, Andrea Schenk, André Homeyer, Arne Schenk, Fabian Kiessling, Hermann-Georg Holzhütter, Jan Georg Hengstler, Lars Küpfer, Lars Ole Schwen, Markus Krauß, Serene Lee, Tobias Preusser, Uta Dahmen, Ute Hofmann

Other contributors: Felix Gremse, Benjamin Knowles

Scales: Cell, Liver lobule, Liver and Organism

presentation at SBMC2014

Created: 14th May 2014 at 15:30   Last updated: 14th May 2014 at 15:55


Genericblue Multiscale Simulation of Zonated Metabolism in Steatotic Livers

Uploader: Lars Ole Schwen

Contributor: André Homeyer, Arne Schenk, Lars Küpfer, Lars Ole Schwen, Michael Schwier, Olaf Dirsch, Tobias Preusser, Uta Dahmen

Other contributors: Felix Gremse

Scales: Cell, Liver lobule, Liver and Organism

Presentation at VPH 2014

Created: 11th Sep 2014 at 09:50

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