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Kinetic Modelling of Carbohydrate & Lipid Metabolism in Human Hepatocytes

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Motivation
The central carbon metabolism of the liver enables the remarkable homeostasis of numerous plasma metabolites under a wide variety of nutritional regimes and physiological states. Examples are the synthesis of glucose by gluconeogenesis and synthesis of ketone-body from fatty acids under fasting conditions or the postprandial storage of glucose and lipids in terms of glycogen and triglycerides.

Results
In order to better understand the regulatory mechanism accounting for the switch between alternative metabolic modes depending on physiological state and available nutrients we developed a detailed kinetic model of the central metabolism of human hepatocytes integrated with the hormonal control by insulin, glucagon and epinephrine.

Filename: Koenig_SBMC2012_Poster.pdf

Format: PDF document

Size: 3.35 MB


help Contributors

[Matthias König] [Nikolaus Berndt] [Hermann-Georg Holzhütter]

help Attributions

None

help Scales


Cell and Liver
Views: 1936    Downloads: 923
  • Created: 9th Jul 2012 at 20:15
  • Last updated: 9th Jul 2012 at 20:20
  • Last used: 15th Jun 2019 at 22:01

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