Kformula Kinetic Model of Hepatic Glucose Metabolism

Uploader: Matthias König

Contributor: Hermann-Georg Holzhütter, Matthias König, Sascha Bulik

Other contributors: Not specified

Model type: Ordinary differential equations (ODE)

Model format: SBML

Scales: Cell and Liver

Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical
model of human hepatic glucose metabolism is lacking so far. Here we present a
detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in
human hepatocytes integrated with the hormonal control of these pathways by insulin,
glucagon and epinephrine. Model simulations are in good agreement with experimental
data on (i) the quantitative contributions of glycolysis, gluconeogenesis, and glycogen

Created: 14th Mar 2012 at 00:59   Last updated: 16th Feb 2017 at 12:12

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