A community-driven global reconstruction of human metabolism.

Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ∼2× more reactions and ∼1.7× more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.

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http://www.ebi.ac.uk/biomodels-main/download?mid=MODEL1109130000 Website Link

Organism: Homo sapiens

Model type: Not specified

Model format: SBML

Execution or visualisation environment: Not specified

Model image: No image specified

This Model was originally imported from the BioModels Database: http://www.ebi.ac.uk/biomodels-main/MODEL1109130000.

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[Christian Bölling] [Nicolas Le Novère] [Andreas Hoppe]

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Views: 1971
  • Created: 27th Nov 2013 at 10:35
  • Last used: 22nd Sep 2021 at 03:17

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