Biological problem addressed 'Modelling Analysis'
No parent terms
Modelling Analysis
Cell cycle (0) | Enzymology (0) | Gene expression (1) | Gene regulatory network (1) | Genome scale (0) | Metabolic network (2) | Metabolism (0) | Signal transduction (0) | Translation (0)
Related assays
ID: 7
Biological problem addressed: Gene expression
Investigation: Exchanging culture medium
Contributor: Data From HepatoSys
Projects: HepatoSys
Organisms:
Mus musculus : C57BL/6N (wild-type / wild-type) : [Hepatocyte] (primary cell culture)
SOPs: No SOPs
Data files: Dynamic network reconstruction identified unexp...
Scales: Cell
Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse
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Created: 1st Aug 2011 at 15:44 Last updated: 24th Jul 2015 at 11:50
ID: 70
Biological problem addressed: Gene regulatory network
Investigation: 1 hidden item
Study: 1 hidden item
Models: 4 hidden items
Contributor: Sebastian Vlaic
Projects: A: Cellular level
Organisms: Not Specified
SOPs: No SOPs
Data files: GRN2SBML Bundle
Scales: Cell
Created: 1st Nov 2013 at 10:42 Last updated: 24th Jul 2015 at 13:29
ID: 71
Biological problem addressed: Metabolic network
Investigation: Investigation: Multi-scale model galactose meta...
Study: Study : Galactose metabolism in the liver
Models: 2 hidden items
Contributor: Matthias König
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., C1: The role of blood flow in liver lobule function and morphology, C2: Organization of the sinusoidal system and the liver lobule - referen..., C3: Zonation of metabolism and its regulation
Organisms: Not Specified
SOPs: No SOPs
Data files: No Data files
Scales: Cell, Liver lobule and Liver
We present a multi-scale model of liver galactose metabolism bridging the scales from single-cell metabolism over the tissue level to the whole-organ. The model combines a detailed kinetic model of the cellular galactose metabolism with a tissue-scale perfusion model of the sinusoid. The metabolic capacity of the whole liver is modelled by integrating the heterogeneous contribution of sinusoids differing in blood-flow rates and tissue-architecture. The model was applied to the normal physiological
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Created: 3rd Nov 2013 at 15:17 Last updated: 24th Jul 2015 at 13:30
ID: 72
Biological problem addressed: Metabolic network
Investigation: Investigation: Glucose metabolism in the liver
Contributor: Matthias König
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions
Organisms: Not Specified
SOPs: No SOPs
Data files: No Data files
