Biological problem addressed 'Modelling Analysis'

Related assays


Desktop Response of hepatocytes to rapid change in the medium composition (gene regulatory network)

Contributor: Data From HepatoSys

Projects: HepatoSys

Mus musculus : C57BL/6N (wild-type / wild-type) : [Hepatocyte] (primary cell culture)


Data files: Dynamic network reconstruction identified unexp...

Scales: Cell

Primary hepatocytes were exposed to a stimulus by exchanging culture medium, thereby simulating changes in the blood composition. The expression of genes at different time points was recorded. Differentially expressed genes were clustered using fuzzy c-means algorithm into five groups. The arcs of the possible network were identified using the NetGenerator algorithm under the restriction of biological knowledge. The analysis was restricted to the main metabolic pathways of hepatocytes. The reverse

Created: 1st Aug 2011 at 15:44   Last updated: 24th Jul 2015 at 11:50


Desktop GRN2SBML: encoding of gene regulatory network models

ID: 70

Biological problem addressed: Gene regulatory network

Investigation: 1 hidden item

Study: 1 hidden item

Models: 4 hidden items

Contributor: Sebastian Vlaic

Projects: A: Cellular level

Organisms: Not Specified


Data files: GRN2SBML Bundle

Scales: Cell

No description specified

Created: 1st Nov 2013 at 10:42   Last updated: 24th Jul 2015 at 13:29


Desktop From Hepatocytes to Whole Liver Function: A Multi-Scale Model of Human Hepatic Galactose Metabolism

ID: 71

Biological problem addressed: Metabolic network

Investigation: Investigation: Multi-scale model galactose meta...

Study: Study : Galactose metabolism in the liver

Models: 2 hidden items

Scales: Cell, Liver lobule and Liver

We present a multi-scale model of liver galactose metabolism bridging the scales from single-cell metabolism over the tissue level to the whole-organ. The model combines a detailed kinetic model of the cellular galactose metabolism with a tissue-scale perfusion model of the sinusoid. The metabolic capacity of the whole liver is modelled by integrating the heterogeneous contribution of sinusoids differing in blood-flow rates and tissue-architecture. The model was applied to the normal physiological

Created: 3rd Nov 2013 at 15:17   Last updated: 24th Jul 2015 at 13:30


Desktop Kinetic modelling of hepatic glucose metabolism

Contributor: Matthias König

Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A3.4: Linking signalling to metabolic functions

Organisms: Not Specified


Data files: No Data files

Scales: Cell and Liver

No description specified

Created: 3rd Nov 2013 at 16:43   Last updated: 24th Jul 2015 at 13:31

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