Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload


The regulatory axis between the iron hormone hepcidin and its receptor, the iron exporter ferroportin (FPN), is central to iron homeostasis. Mutations preventing hepcidin-mediated degradation of FPN cause systemic iron overload. We have introduced a point mutation (C326S) into the murine Fpn locus, resembling human hereditary hemochromatosis type 4, including elevated plasma iron and ferritin levels, high transferrin saturation, hepatic iron overload, and iron depletion of duodenal enterocytes and reticuloendothelial macrophages. Unlike other mouse models of iron overload, homozygous C326S mice die between 7 and 14 months of age. Pancreatic acinar cells display marked iron accumulation, oxidative damage and degeneration, associated with failure of the exocrine pancreas and severe body weight loss. Rescue experiments reveal iron overload and exocrine pancreatic failure as leading causes of death. This work uncovers the critical importance of the hepcidin-ferroportin regulatory axis for life and unveils the sensitivity of the exocrine pancreas to iron overload.


Projects: B1.3: Linking modulation of iron metabolism with the impact of macrophag...

Cell Metab.
Cell Metab. 20(2): 359-67
8th Aug 2014

Sandro Altamura, Regina Kessler, Hermann-Josef Gröne, Norbert Gretz, Matthias W Hentze, Bruno Galy, Martina U Muckenthaler

help Authors

[Matthias Hentze] [Bruno Galy] [Martina Muckenthaler]

help Attributions


Views: 1130
  • Created: 21st Jan 2015 at 10:21

Related items


Log in / Register

Need an account?
Sign up

Forgotten password?

Front Page

Virtual Liver Network


Related Projects and friends

Imprint Taverna workflow workbench myExperiment JWS Online ISATAB myGrid Sabio-RK BioPortal Semantic SBML

Powered by:


Silk icons 1.3
Crystal Clear icons