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Identifiability and observability analysis for experimental design in nonlinear dynamical models

Abstract:

Dynamical models of cellular processes promise to yield new insights into the underlying systems and their biological interpretation. The processes are usually nonlinear, high dimensional, and time-resolved experimental data of the processes are sparse. Therefore, parameter estimation faces the challenges of structural and practical nonidentifiability. Nonidentifiability of parameters induces nonobservability of trajectories, reducing the predictive power of the model. We will discuss a generic approach for nonlinear models that allows for identifiability and observability analysis by means of a realistic example from systems biology. The results will be utilized to design new experiments that enhance model predictiveness, illustrating the iterative cycle between modeling and experimentation in systems biology.

21198117

Projects: A2: Integration of Signalling Pathways in Hepatocellular Response

Chaos
Chaos 20(4): 045105
5th Jan 2011

A Raue, V Becker, U Klingmüller, J Timmer

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[Andreas Raue] [Ursula Klingmüller] [Jens Timmer]

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Cell
Views: 1452
  • Created: 10th Aug 2012 at 09:43
  • Last updated: 24th Oct 2013 at 16:19

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