Presentations

 

Pdf WBI-NER: The impact of domain-specific features on the performance of identifying and classifying mentions of drugs


Uploader: Michael Weidlich

Contributor: Michael Weidlich, Tim Rocktäschel, Ulf Leser

Other contributors: Torsten Huber

Version: 1

Projects: F2: The Liver Knowledge Base (LKB)

Scales: Organism

Named entity recognition (NER) systems are often based on machine learning techniques to reduce the labor-intensive development of hand-crafted extraction rules and domain-dependent dictionaries. Nevertheless, time-consuming feature engineering is often needed to achieve state-of-the-art performance. In this study, we investigate the impact of such domain-specific features on the performance of recognizing and classifying mentions of pharmacological substances. We compare the performance of a
...

Created: 16th Dec 2013 at 09:53


 

Pdf Whole genome array analysis of cultured mouse hepatocytes identifies a JNK pathway mediated Acute Phase Response (APR) signature


Uploader: Agata Widera

Contributor: Agata Widera, Gisela Campos, Jan Georg Hengstler, Patricio Godoy, Reinhard Guthke, Rolf Gebhardt, Steven Dooley, Wolfgang Schmidt-Heck

Other contributors: Katharina Rochlitz, Nils Blüthgen

Scales: Cell

Primary hepatocytes are a fundamental tool to investigate molecular mechanisms in liver physiopathology. Hepatocytes cultured on a 2D collagen
monolayer (CMS for sub-confluent and CMC for confluent) quickly de-differentiate, becoming apoptotic resistant and loosing canalicular polarity,
whereas when cultured on a 3D extracellular matrix (e.g. collagen sandwich, S) they can better sustain a differentiated state and form bile canaliculi
(BC) making the latter system feasible for using hepatocytes
...

Created: 8th Jan 2013 at 11:45   Last updated: 8th Jan 2013 at 12:42


 

Pdf Whole genome array analysis of cultured mouse hepatocytes identifies a JNK pathway mediated Acute Phase Response (APR) signature


Uploader: Agata Widera

Contributor: Agata Widera, Gisela Campos, Jan Georg Hengstler, Patricio Godoy, Reinhard Guthke, Rolf Gebhardt, Steven Dooley, Wolfgang Schmidt-Heck

Other contributors: N. Blüthgen

Version: 2

Projects: No Projects

Scales: Not specified

Background: The liver is an organ acting as a first line of defense against a number of pathological conditions including sepsis via an acute phase response (APR). Primary hepatocytes are a fundamental tool to fully understand the complex circuitry of signal transduction and gene regulation in APR. However, it is known that primary hepatocytes undergo a dedifferentiation process, i.e., apoptotic resistance and epithelial to mesenchymal transition. These alterations are being partly repressed in
...

Created: 25th Jul 2012 at 14:04



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