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Uploader: Bernd Binder
Contributor: Bernd Binder
Other contributors: Not specified
Version: 1
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal...
Scales: Not specified
We investigate the influence of insulin, glucagon and epinephrine on the core metabolism of hepatocytes by means of a kinetic model. These hormones induce significant alterations in certain metabolic activities of key enzymes like Glycogen synthase and Glycogen phosphorylase. Insulin is the primary anabolic hormone promoting the storage of energy by stimulating, for example, the glycogen synthesis. The effect of Glucagon and epinephrine are opposite that of insulin. They cause the liver to convert
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Created: 23rd Jul 2012 at 14:31 Last updated: 25th Jul 2012 at 14:01
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Download Uploader: Bernd Binder
Contributor: Bernd Binder
Other contributors: Not specified
Version: 1
Projects: Virtual Liver
Scales: Cell
We investigate the influence of insulin, glucagon and epinephrine on the core metabolism of hepatocytes by means of a kinetic model. These hormones induce significant alterations in certain metabolic activities of key enzymes like Glycogen synthase and Glycogen phosphorylase. Insulin is the primary anabolic hormone promoting the storage of energy by stimulating, for example, the glycogen synthesis. The effect of Glucagon and epinephrine are opposite that of insulin. They cause the liver to convert
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Created: 12th Jul 2012 at 12:51 Last updated: 17th Jul 2012 at 14:06
Uploader: Matthias König
Contributor: Hermann-Georg Holzhütter, Matthias König, Nikolaus Berndt
Other contributors: Not specified
Version: 1
Projects: A1.1: Central liver metabolism and its regulation under nutritional chal..., A1: Cellular metabolism
Motivation
The central carbon metabolism of the liver enables the remarkable homeostasis of numerous plasma metabolites under a wide variety of nutritional regimes and physiological states. Examples are the synthesis of glucose by gluconeogenesis and synthesis of ketone-body from fatty acids under fasting conditions or the postprandial storage of glucose and lipids in terms of glycogen and triglycerides.
Results
In order to better understand the regulatory mechanism accounting for the switch
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Created: 9th Jul 2012 at 20:15 Last updated: 9th Jul 2012 at 20:20
